That's not this. It's a false equivalency.
You've just restated the same error as the thing I responded to
The thing you'd be "zeroing" in this situation would be to find a specified road and weather condition and then demonstrate the existence of a drag coefficient by letting the car coast down the same hill with the top on or off and seeing how far it goes before stopping and how long it takes to get there
In your analogy you'd be up against the assumption that fuel economy is universally constant. Here, you're trying to show that it's not constant and the shape of the vehicle is part of the reason why.
You do this by removing confounding variables to demonstrate whether a phenomena is real or just a confluence of other things and merely presenting a convincing illusion.
We would want to take engine combustion and driving habits out of the tests. We would be pushing the car off at neutral down the hill. You want those noise creating events to not disrupt your signal
We're trying to establish if something is potentially real.
Coincidentally there's been a slew of bogus fuel efficiency additive products that have measurable effects because the people using them habitually change their driving style creating a false positive. Grifters have successfully been hawking this driving placebo scam for 50 years because when you bring all the other stuff in it's hard to tell what's real and what's just in the head. It's easy to falsely attribute things based on the stories we like to tell ourselves.
Also to extend the car pushing thing to the counternarrative example someone could claim that it was merely the tires were warmed up the second run, thus being more inflated and that's what caused a time discrepancy so drag coefficient is still an unsupported idea. No matter what you do, there's always a hole somewhere. That's why it's gotta be more than one type of demonstration. To borrow a French idiom, it's all about cherchez le creneau and constructing new experiments.