>>"I am sure that many of the erudite readers of this little book know On the Origin of Species by Charles Darwin inside and out. " I can't parse that sentence. Does it make sense? (English is not my first language)
"I am sure that many [...] readers of this [...] book know [the book] 'On the Origin of Species' (by Charles Darwin) inside and out."
Edit: "to know something inside and out" means to be very familiar with something.