Live data from Hacker News

Psilocybin 'promising' for depression

bbc.co.uk

41–50 of 324 posts

Re: Psilocybin 'promising' for depression

#41
post #26

On the one hand, HN is terrified of brain-computer interfaces manipulating our brains and emotions, on the other hand, they're totally psyched about using mushrooms to do the same thing.

It's not even remotely the same thing. One is a chemical compound that temporarly messes with the way your brain work, the other is an permanent (?) extension to your brain that allows to manipulate it from the outside. Also, HN is not one person with a single opinion.

Re: Psilocybin 'promising' for depression

#42

Earlier quoted context omitted.

The drug has dangers, but they seem small compared to those of alcohol, even if largely orthogonal. It got banned because it wasn't understood in the best case, to curb the counterculture movement from the 60s in the worst, but it's always been hard to justify it with medical reasons; it's been just tagged along with cocaine or heroin and made bad by association.

But if there hasn’t been significant medical research, how do we know there are no long-term dangers?

Do you not think huge quantities of people do it all the time right now? Because, well, they do. Further there were a lot of experiments with psychedelics in the 60s.

Re: Psilocybin 'promising' for depression

#43

Earlier quoted context omitted.

I know a lot of people whose minds were ruined by psychedelics. It’s something you will see when you spend time in those communities. It doesn’t happen to everyone, but it’s common.

I get it - a drug is a drug - and like all drugs I am not saying that psychedelics are a cure all for all people. What I am saying is that it is depressing that we are only just seeing reports from formal sources that psychedelics could be useful for some people.

I mean we could just discuss the issue of freedom and making it illegal for people to grow and consume a mushroom and stop making it about just drugs. Marijuana is the same way. If it isn't for someone then they shouldn't do it and we should make as much information available about something available and provide safe environments, but making it illegal especially when plenty of people have experienced positive effects sometimes profound religious experiences it is just another mechanism of control and taking away freedom and natural rights.

Re: Psilocybin 'promising' for depression

#44
post #40

I don’t want to live in a world where the solution to depression (caused by governments, politicians, or general existence in the modern capitalist world) is a drug. Not a good idea. Instead, figure out why depression has increased so dramatically in the last ~century and address that.

I don't want to live in a world where how you want the world to look affects my freedom to eat certain foods.

Nowhere did I say that prohibition is a good idea. The article isn’t about that, it’s about using drugs to “cure” depression.

Re: Psilocybin 'promising' for depression

#45

Earlier quoted context omitted.

But if there hasn’t been significant medical research, how do we know there are no long-term dangers?

Do you not think huge quantities of people do it all the time right now? Because, well, they do. Further there were a lot of experiments with psychedelics in the 60s.

That’s not how medical research works.

Re: Psilocybin 'promising' for depression

#46

I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…

I know a lot of people whose minds were ruined by psychedelics. It’s something you will see when you spend time in those communities. It doesn’t happen to everyone, but it’s common.

Which psychedelics?

I've pushed the limits with many tryptamines (at least 300-400 discrete experiences) and 15 years later my cognitive abilities are measurably excellent.

Re: Psilocybin 'promising' for depression

#47

Earlier quoted context omitted.

The drug has dangers, but they seem small compared to those of alcohol, even if largely orthogonal. It got banned because it wasn't understood in the best case, to curb the counterculture movement from the 60s in the worst, but it's always been hard to justify it with medical reasons; it's been just tagged along with cocaine or heroin and made bad by association.

But if there hasn’t been significant medical research, how do we know there are no long-term dangers?

Then we have way too many measuring sticks.

1. Medical consensus say it's bad, but it's kept legal: tobacco, alcohol, drinking bleach.

2. There's no medical consensus, but it's forbidden anyway: LSD, mushrooms, DMT...

3. Medical consensus say it's bad, and it's forbidden: cocaine, heroin, meth...

4. Medical consensus say it's good, but we ban it anyway: MDMA in the context of psychotherapy [0].

5. There's no medical consensus, but we ban some yet not others that have an identical mechanism of action: poppers

That's without getting into the fact that the federal schedule system is seemingly impermeable, and cocaine or heroin have accepted medical uses, but somehow weed doesn't, despite all the evidence it does.

[0] Linking because maybe not many are aware: https://journals.sagepub.com/doi/full/10.1177/20503245187674...

Re: Psilocybin 'promising' for depression

#48

Earlier quoted context omitted.

Why, the next best thing after significant medical research, anecdotal research! So far so good.

So far in this topic, it’s been research of the “my friend said” kind. Which is even less reliable than direct anecdotal research.

My friend doesn't like to admit to things that might be considered a crime, it's just how it goes in a police state.

Re: Psilocybin 'promising' for depression

#49
Are psychedelics connected to dreaming? I mean, maybe dreams are supposed to somehow reset or recalibrate brains, but on some people it's not working for some reason. Also, there's a connection of what you eat and what you dream, so my wild hypothesis is that gut bacteria is responsible for recalibrating your brain during sleep. There's also quite strong evidence for correlation between gut bacteria and mental health. Somehow these are connected. Also, exercise, especially running has a mental health effect. Maybe it just mixes your gut bacteria.

Re: Psilocybin 'promising' for depression

#50

I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…

I know a lot of people whose minds were ruined by psychedelics. It’s something you will see when you spend time in those communities. It doesn’t happen to everyone, but it’s common.

In what way were their minds ruined?
Post reply on HN