Earlier quoted context omitted.
My memory is generally terrible. One discovery that was alarming, encouraging and disturbing at the same time is that I do appear to have some form of nearly total recall buried in there somewhere. Unfortunately it only surfaces in one way. If I listen to a podcast while I’m doing something, then listen to that same podcast again within a week or so, I will have regular, intrusive visual recall of exactly what I was…
That's sort of fascinating- it reminds me of how the ancient romans used to memorize long epic poems etc (walking around and making visual/spatial associations, then recalling their travel to recite it later. I might be butchering that a bit but that's how I understood the method)
Neuroscientists discover molecular mechanism that allows memories to form (2020)
71–80 of 88 posts
Re: Neuroscientists discover molecular mechanism that allows memories to form (2020)
#72Earlier quoted context omitted.
@Robotbeat isn't the one missing the point here. The incredible accuracy of those predictions serves as a testament to just how well we do understand that particular phenomenon. Now compare to neuroscience, where we struggle to accurately make (by comparison) the most basic of predictions.
> Now compare to neuroscience, where we struggle to accurately make (by comparison) the most basic of predictions. I'm not addressing the hand wavy nature of the article, which is self-evident. This is irrelevant to the point being discussed.
You might want to reread the thread for context. You don't seem to be discussing the same point as the people you're replying to.
Re: Neuroscientists discover molecular mechanism that allows memories to form (2020)
#73Earlier quoted context omitted.
Quantum chemistry is a field with a lot of unknowns still. To say that chemistry has a complete understanding of the hydrogen atom is inaccurate.
... what?! We can accurately predict hydrogen (and helium!) energy characteristics to _absurd_ accuracy levels. The issue is that even a system as simple as a single helium atom is prohibitively computationally expensive.
Re: Neuroscientists discover molecular mechanism that allows memories to form (2020)
#74I experienced an episode of transient global amnesia [1] a couple of years ago. It lasted for 6-7 hours, during which I was transported to the hospital, but every 2-3 minutes I would ask anew "Why am I in the hospital?" — having no memory at all of being there. I still have no clue what might have caused it. I mean, scientists don't have a clue what causes it, only a wide range of speculated causes, none of which rea…
I suspect the issue may be the lack of a good biological model. I'd guess it would be a very attractive and obvious research target for anyone aiming to investigate memory formation and recall. However, systematic studies generally require a model system that can be reliably reproduced.
Re: Neuroscientists discover molecular mechanism that allows memories to form (2020)
#75Earlier quoted context omitted.
... what?! We can accurately predict hydrogen (and helium!) energy characteristics to _absurd_ accuracy levels. The issue is that even a system as simple as a single helium atom is prohibitively computationally expensive.
There's more to quantum chemistry (and hydrogen atoms) than what you're saying. If you define chemistry tautologically as what we know, then sure I guess.
Re: Neuroscientists discover molecular mechanism that allows memories to form (2020)
#76I experienced an episode of transient global amnesia [1] a couple of years ago. It lasted for 6-7 hours, during which I was transported to the hospital, but every 2-3 minutes I would ask anew "Why am I in the hospital?" — having no memory at all of being there. I still have no clue what might have caused it. I mean, scientists don't have a clue what causes it, only a wide range of speculated causes, none of which rea…
Re: Neuroscientists discover molecular mechanism that allows memories to form (2020)
#77I experienced an episode of transient global amnesia [1] a couple of years ago. It lasted for 6-7 hours, during which I was transported to the hospital, but every 2-3 minutes I would ask anew "Why am I in the hospital?" — having no memory at all of being there. I still have no clue what might have caused it. I mean, scientists don't have a clue what causes it, only a wide range of speculated causes, none of which rea…
> Since there's no known way to prevent TGA, no treatment, and apparently no lasting damage, it has never (AFAIK) been researched, certainly not researched much I suspect the issue may be the lack of a good biological model. I'd guess it would be a very attractive and obvious research target for anyone aiming to investigate memory formation and recall. However, systematic studies generally require a model system that…
Re: Neuroscientists discover molecular mechanism that allows memories to form (2020)
#78Earlier quoted context omitted.
> Since there's no known way to prevent TGA, no treatment, and apparently no lasting damage, it has never (AFAIK) been researched, certainly not researched much I suspect the issue may be the lack of a good biological model. I'd guess it would be a very attractive and obvious research target for anyone aiming to investigate memory formation and recall. However, systematic studies generally require a model system that…
Indeed, studying TGA would mean finding these people who have 2-8 hour episodes.
Possibly, but I strongly suspect humans wouldn't be very good models in this case given how much we don't know about memory in general. Rather you'd want a robust non-human animal model of some sort, with a straightforward way of inducing TGA (or something that appeared to be substantially similar) on demand. Think rodent with optogenetic modifications or similar.
Re: Neuroscientists discover molecular mechanism that allows memories to form (2020)
#79Please please don't take away from this that there are "memory cells" that "encode memories." The article is so badly written it seems to imply that. Memory is a whole brain phenomenon, and memory formation involves connections being formed and lost constantly between all types of neurons everywhere in the brain. One small aspect of memory (episodic memory) relies more heavily on hippocampal neurons during consolidat…
So, isn’t the nature of memory in the brain still understood pretty vaguely? The “memory is connections and involves the whole brain” is still kind of a hypothesis and less of a hard, empirically-validated theory, no? May still be the best idea we have, but from what I understand (which isn’t much), it’s not nearly that cut and dry and we don’t really know enough to exclude a lot of the other models of memory formati…
Re: Neuroscientists discover molecular mechanism that allows memories to form (2020)
#80It started decades ago with seminal work on place & grid cells in spatial navigation (https://www.nobelprize.org/prizes/medicine/2014/may-britt-mo...) which was later shown to be generalizable to multidimensional "concept spaces".
It's probably the most exciting field in neuroscience right now, it also maps very nicely into mathematics of high-dimensional spaces:
"Navigating cognition: Spatial codes for human thinking" https://science.sciencemag.org/content/362/6415/eaat6766.abs...
"Organizing conceptual knowledge in humans with a gridlike code" https://science.sciencemag.org/content/352/6292/1464
"The Hippocampus Encodes Distances in Multidimensional Feature Space" https://www.sciencedirect.com/science/article/pii/S096098221...
"A non-spatial account of place and grid cells based on clustering models of concept learning" https://www.nature.com/articles/s41467-019-13760-8
"A learned map for places and concepts in the human MTL" https://www.biorxiv.org/content/10.1101/2020.06.15.152504v1....
"What Is a Cognitive Map? Organizing Knowledge for Flexible Behavior" https://www.sciencedirect.com/science/article/pii/S089662731...
"A map of abstract relational knowledge in the human hippocampal–entorhinal cortex" https://elifesciences.org/articles/17086
"Map-Like Representations of an Abstract Conceptual Space in the Human Brain" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884611/
"Knowledge Across Reference Frames: Cognitive Maps and Image Spaces" https://www.sciencedirect.com/science/article/pii/S136466132...
"Concept formation as a computational cognitive process" https://www.sciencedirect.com/science/article/pii/S235215462...
"Efficient and flexible representation of higher-dimensional cognitive variables with grid cells" https://journals.plos.org/ploscompbiol/article?id=10.1371/jo...
"The cognitive map in humans: spatial navigation and beyond" https://www.nature.com/articles/nn.4656
"A general model of hippocampal and dorsal striatal learning and decision making" https://www.pnas.org/content/117/49/31427.short
"On the Integration of Space, Time, and Memory" https://www.sciencedirect.com/science/article/pii/S089662731...