Before Django the gold standard for Python web apps was Zope. What a tremendous achievement by the Django team!
I remember Zope was pretty universally disliked by Python programmers. But it was for a time probably the most enterprisey thing with Python inside, so maybe it got more points in corporate places as something to try as an alternative to Enterprise Java Buzzwords. Before Django there was a lot of choice and active libraries / frameworks for Python web app development, IME most apps gravitated more towards "ala carte"…
It might not have the replication / distributed features though.