Exercise may help slow cognitive decline in some people with Parkinson’s disease • Hacker News Board

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#21

Post by meowface » Sat, Apr 03, 2021, 3:38 PM UTC

_Microft wrote: post #9

wrongdonf wrote: post #2

Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on. And it turns out that this metabolic defense mechanism i…

"ISRIB" seems be this compound: https://en.wikipedia.org/wiki/ISRIB It always helps to expand abbreviations when talking about things that only a few readers will already know about. Typing it out is O(1) , having N people look it up is O(N) if you allow me to abuse the notation like that ;)

>Typing it out is O(1), having N people look it up is O(N) if you allow me to abuse the notation like that ;)

Thank you; this is a perfect way to put it. I always include links, and ideally inline text, when posting because I always try to think from the perspective of a lazy and/or context-switch-averse reader reading the comment. (Easy to do, since that's my actual perspective 99.9% of the time.) One of my highest-upvoted HN comments was just pasting the contents of a tweet someone else posted to save people a click. (https://news.ycombinator.com/item?id=25260896)

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#22

Post by mettamage » Sat, Apr 03, 2021, 3:45 PM UTC

wrongdonf wrote: post #2

Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on. And it turns out that this metabolic defense mechanism i…

I know nothing about the medical field. To me, this reads like a fictional story. Is this a plausible story? I really don't know.

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#23

Post by oceanghost » Sat, Apr 03, 2021, 4:03 PM UTC

wrongdonf wrote: post #2

Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on. And it turns out that this metabolic defense mechanism i…

This is easily the most fascinating comment I have ever read on HN. Thank you!

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#24

Post by DoreenMichele » Sat, Apr 03, 2021, 4:03 PM UTC

Exercise moves lymph out of the general tissues, though the brain only moves lymph in sleep. This is how the body "takes out the trash."

Longer explanation in previous comment:

https://news.ycombinator.com/item?id=25427090

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#25

Post by DoreenMichele » Sat, Apr 03, 2021, 4:14 PM UTC

wrongdonf wrote: post #2

Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on. And it turns out that this metabolic defense mechanism i…

She became lucid again but died a day or two later. We speculated that one of the reasons cells turn themselves off is because they are too dysfunctional to operate — so turning them back on brings the benefit of having that signal again in the case of neurons but also revives any dangerous behavior that was being suppressed.

That's a pretty big leap to make given that you don't even know if there is, in fact, some kind of causal relationship between giving her ISRIB, her sudden lucidity and subsequent death. According to what you have said, it was a one off event and you are positing a hypothesis of how the body works based on a one off event where you don't even know if x led to y led to z and your hypothesis is based on the assumption those things were, in fact, causally related.

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#26

Post by reducesuffering » Sat, Apr 03, 2021, 4:18 PM UTC

wrongdonf wrote: post #2

Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on. And it turns out that this metabolic defense mechanism i…

> because I was having a medical emergency from experimenting with a totally unrelated compound. It nearly killed me, I spent weeks in the asylum and still have lingering effects.

You should name this in case others might be, present or future, using the same substance.

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#27

Post by bobthepanda » Sat, Apr 03, 2021, 5:21 PM UTC

Forge36 wrote: post #13

So you're saying there's nothing we can do? /s https://medlineplus.gov/benefitsofexercise.html https://www.mayoclinic.org/healthy-lifestyle/fitness/in-dept... Google's quick questions+answers: What are the 10 benefits of exercise? What are 20 benefits of exercise? More results What are 15 benefits of exercise? What are some benefits of exercise? How many minutes should you play or exercise every day? What are the 5 b…

The easiest exercise to do is the kind that is routine and integrated into your routine so much you don’t even think about it. When I lived in New York I walked a few blocks to the bus stop, down the stairs to the train, down the stairs to another train, and then a few blocks to work. And that was just the commute; not counting walks to the coffee shop for a break, the walk to pick up lunch, the walk to the subway to the bar or a friend’s house after work, etc.

The problem is that, at least in the US, most people walk within a building or from the door to the car and that’s about it, and then we have to create silly rituals like culty group bicycle classes or 10,000 steps challenges to actually get the minimum exercise in.

We don’t necessarily need to go back to everyone working the fields all day levels of work, but the sedentary lifestyle in the US is not helping matters.

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#28

Post by TheCoelacanth » Sat, Apr 03, 2021, 6:18 PM UTC

Gatsky wrote: post #7

Waiting for a study showing exercise does not improve outcome X. Seriously, do we need any more positive exercise studies? If you are a mammal, then exercise is good for you, let’s be done with it.

That is a safe assumption if you are deciding whether or not to exercise, but that doesn't mean we have learned everything there is to learn about the effect of exercise.

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#29

Post by wrongdonf » Sat, Apr 03, 2021, 7:22 PM UTC

reducesuffering wrote: post #26

wrongdonf wrote: post #2

Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on. And it turns out that this metabolic defense mechanism i…

> because I was having a medical emergency from experimenting with a totally unrelated compound. It nearly killed me, I spent weeks in the asylum and still have lingering effects. You should name this in case others might be, present or future, using the same substance.

It’s in clinical trials. It’s also very obscure and doesn’t get you high at any dose

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#30

Post by wrongdonf » Sat, Apr 03, 2021, 7:28 PM UTC

DoreenMichele wrote: post #25

wrongdonf wrote: post #2

Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on. And it turns out that this metabolic defense mechanism i…

She became lucid again but died a day or two later. We speculated that one of the reasons cells turn themselves off is because they are too dysfunctional to operate — so turning them back on brings the benefit of having that signal again in the case of neurons but also revives any dangerous behavior that was being suppressed. That's a pretty big leap to make given that you don't even know if there is, in fact, some k…

What model requires less evidence than a hypothesis?