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Exercise may help slow cognitive decline in some people with Parkinson’s disease

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Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#11

Post by chiefalchemist »

Gatsky wrote: post #7

Waiting for a study showing exercise does not improve outcome X. Seriously, do we need any more positive exercise studies? If you are a mammal, then exercise is good for you, let’s be done with it.

We survived because of movement, and other natural attributes. "Progress" (i.e., a forced shift from proactive living entities to reactive consumers) comes along and suddenly our evolutionary past is denied (usually for profit). There's nothing wrong with profit, unless it is the primary measurement of success and progress.

Of course there's collateral damage, we're denying a massive chunk of our evolutionary makeup, our very nature. Another study to confirm this? Perhaps we're not the advanced species we make ourselves out to be?

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#12

Post by _Microft »

Gatsky wrote: post #7

Waiting for a study showing exercise does not improve outcome X. Seriously, do we need any more positive exercise studies? If you are a mammal, then exercise is good for you, let’s be done with it.

I disagree that conjectures are equal to knowledge. The results might not be unexpected but you never know until you actually take a closer look.

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#13

Post by Forge36 »

So you're saying there's nothing we can do? /s

https://medlineplus.gov/benefitsofexercise.html https://www.mayoclinic.org/healthy-lifestyle/fitness/in-dept...

Google's quick questions+answers: What are the 10 benefits of exercise? What are 20 benefits of exercise? More results What are 15 benefits of exercise? What are some benefits of exercise? How many minutes should you play or exercise every day? What are the 5 benefits of health and wellness?

I'm curious how they could control for the general benefit of exercise or if it this study is more "parkinson's does not prevent benefit to exercise". I wonder if future generations will look back on this and say "they were exceedingly lazy to the point of serious mental disease and decline"

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#14

Post by beowulfey »

wrongdonf wrote: post #2

Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on. And it turns out that this metabolic defense mechanism i…

I am currently learning a lot about the cellular Integrated Stress Response for my research. It is fascinating. There is one curious problem I particularly love. Even though a lot of neuronal communication can be through transient calcium signaling, the ISR is also signaled through calcium. Because they use the same signal, it makes sense that something like overactive neurons could eventually lead to stress. And yet somehow the two signals are differentiated.

It really shows how everything in biology is basically a gaussian curve and you always want to be near the center, but if you steer too far towards either end things start to break down.

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#15

Post by beowulfey »

okoslaatoo wrote: post #6
wrongdonf wrote: post #2

Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on. And it turns out that this metabolic defense mechanism i…

What does "metabolizing carbohydrates correctly" mean in this context? What are the effects when carbohydrates do not metabolize correctly?

It is an inhibitor of whats called the Integrated Stress Response. A “normal” cell is one that uses glucose to create energy and create additional fuel for mitochondria to make LOTS of fuel (caveat- not every cell, this varies a lot, but often enough). This fuel is used to power everything and keep it working well.

Under stress, a lot of that normal machinery is shut down, which means a neuron may not communicate anymore, as all these normal things need lots of energy.

I am not as sure on this point, but I think stress generally means a cell takes in less glucose; it shuts down mitochondria, and overall produces less energy.

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#16

Post by kiba »

Gatsky wrote: post #7

Waiting for a study showing exercise does not improve outcome X. Seriously, do we need any more positive exercise studies? If you are a mammal, then exercise is good for you, let’s be done with it.

The study is not very rigorous.

A limitation of the study was that participants reported their own levels of physical activity, so there is the possibility that they would not remember their levels exactly.

Instead of involving a RCT, we have a survey study.

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#17

Post by wrongdonf »

beowulfey wrote: post #14
wrongdonf wrote: post #2

Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on. And it turns out that this metabolic defense mechanism i…

I am currently learning a lot about the cellular Integrated Stress Response for my research. It is fascinating. There is one curious problem I particularly love. Even though a lot of neuronal communication can be through transient calcium signaling, the ISR is also signaled through calcium. Because they use the same signal, it makes sense that something like overactive neurons could eventually lead to stress. And yet…

If I were in academia I would be putting my career chips on ISR. It’s bursting with potential.

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#18

Post by maxerickson »

researchers also found that greater physical activity at the start of the study lessened APOE e4-related cognitive decline two years later by an average of 0.007 points.

So that sounds meaningless to me. Throw the numbers into the statistics machine I guess, but I bet a decline of 1.33 isn't meaningfully different than a decline of 1.323, even if you can confidently say you measured the difference.

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#19

Post by yhoneycomb »

_Microft wrote: post #9
wrongdonf wrote: post #2

Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on. And it turns out that this metabolic defense mechanism i…

"ISRIB" seems be this compound: https://en.wikipedia.org/wiki/ISRIB It always helps to expand abbreviations when talking about things that only a few readers will already know about. Typing it out is O(1) , having N people look it up is O(N) if you allow me to abuse the notation like that ;)

ISRIB works just as well as "integrated stress response inhibitor." There are multiple stress response inhibitors in the body, so it's not like the name tells you anything. Both are just arbitrary names.

Re: Exercise may help slow cognitive decline in some people with Parkinson’s disease

#20

Post by throwaway_kufu »

okoslaatoo wrote: post #6
wrongdonf wrote: post #2

Recently it was shown that the chemical ISRIB can “undo” traumatic brain injury. It turns out that when you get a concussion, the mechanical stress results in a metabolic self defense mechanism being triggered. Everyone thought the neurons were dying but they were just themselves latent. ISRIB interferes with this defense mechanism, turning the neurons back on. And it turns out that this metabolic defense mechanism i…

What does "metabolizing carbohydrates correctly" mean in this context? What are the effects when carbohydrates do not metabolize correctly?

Excessive blood sugar, then insulin spikes, and over time type 2 diabetes. It used to take a life time to acquire type 2 diabetes and historically it was called adult onset diabetes.

The first case of type 2 diabetes in a child was only diagnosed in the 1983...now it’s common in children. Generally about 1/3 of the US is prediabetic, this population will generally also suffer from other chronic (metabolic) conditions like inflammation and obesity.

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