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Baltimore plant ruins 15M Johnson and Johnson coronavirus vaccines

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Re: Baltimore plant ruins 15M Johnson and Johnson coronavirus vaccines

#11
post #9

This probably explains why only 5M doses of J&J vaccine were allocated for the week of April 5 as opposed to the 11+M that were anticipated. Emergent was also supposed to be approved to ramp up the full supply chain but that hasn’t happened yet, could be related.

In the article it says that these doses were produced in a facility that wasn't approved by the FDA yet, so this has no impact on the availability of doses now. It might have an impact on the availability of doses in the future though.

Re: Baltimore plant ruins 15M Johnson and Johnson coronavirus vaccines

#12

How do you make 15 million of anything without realizing there's an issue, let alone the most scrutinized thing on the planet right now?

It'll be one vat with the potential for 15 million doses... the corrupted mix never reached the individual dose stage.

I find it sad how quick the narrative jumps to the more absurd 15 million number.

Obviously, the mistake is bad. But this is something with a very high fan out. And the smaller number just doesn't get the clicks. :(

Re: Baltimore plant ruins 15M Johnson and Johnson coronavirus vaccines

#13
post #6

Proposition Joe had the connect on lockdown with the eastside and westside working together pumping out 15 million doses. Until young Marlo came in and put a stop to that. The game is the game, vaccines or not.

Well, I stopped looking at news for one week and the frothy right has entirely new sentences I don't understand. Edit: folks stop upvoting this I was missing a cultural reference I didn’t remember.

It’s a reference to the HBO series The Wire.

Re: Baltimore plant ruins 15M Johnson and Johnson coronavirus vaccines

#14
post #9

This probably explains why only 5M doses of J&J vaccine were allocated for the week of April 5 as opposed to the 11+M that were anticipated. Emergent was also supposed to be approved to ramp up the full supply chain but that hasn’t happened yet, could be related.

In the article it says that these doses were produced in a facility that wasn't approved by the FDA yet, so this has no impact on the availability of doses now. It might have an impact on the availability of doses in the future though.

Honest question: if the facility wasn't approved by the FDA then why was it manufacturing the vaccines at all?

And how could such vaccines be used anywhere if they were produced by an unapproved facility?

Re: Baltimore plant ruins 15M Johnson and Johnson coronavirus vaccines

#15
It bothers me that people have expectations of perfection. Of course there will be breaks in the chain the lead to doses being wasted. There are thousands or millions of ways for it to go wrong, and only a few ways for it to go right.

It is an astounding miracle of human progress that we can get to this point.

Re: Baltimore plant ruins 15M Johnson and Johnson coronavirus vaccines

#16

How do you make 15 million of anything without realizing there's an issue, let alone the most scrutinized thing on the planet right now?

Dose is 0.5 ml. Say the batch is equivalent in volume to the final doses (who knows, but it should be somewhere vaguely close). That's 7,500 liters.

Microbrewers often use fermenters larger than that.

Re: Baltimore plant ruins 15M Johnson and Johnson coronavirus vaccines

#17

Earlier quoted context omitted.

In the article it says that these doses were produced in a facility that wasn't approved by the FDA yet, so this has no impact on the availability of doses now. It might have an impact on the availability of doses in the future though.

Honest question: if the facility wasn't approved by the FDA then why was it manufacturing the vaccines at all? And how could such vaccines be used anywhere if they were produced by an unapproved facility?

FDA is likely reviewing their processes and controls more than running a white glove inside of anything.

So those things would be the same for a batch that was in production as they would be for a batch started tomorrow.

Re: Baltimore plant ruins 15M Johnson and Johnson coronavirus vaccines

#18

Earlier quoted context omitted.

In the article it says that these doses were produced in a facility that wasn't approved by the FDA yet, so this has no impact on the availability of doses now. It might have an impact on the availability of doses in the future though.

Honest question: if the facility wasn't approved by the FDA then why was it manufacturing the vaccines at all? And how could such vaccines be used anywhere if they were produced by an unapproved facility?

Maybe the approval process includes a "must have met X criteria for the past Y months", so once you get approved, everything you've done in the past Y months counts as having been created in an approved facility. I'm just guessing though, I have no idea what the process is.

Re: Baltimore plant ruins 15M Johnson and Johnson coronavirus vaccines

#19
post #15

It bothers me that people have expectations of perfection. Of course there will be breaks in the chain the lead to doses being wasted. There are thousands or millions of ways for it to go wrong, and only a few ways for it to go right. It is an astounding miracle of human progress that we can get to this point.

I was ready for the knee-jerk response to pounce and heap damnation on the plant for messing it up. But you have a very valid and insightful point.

Re: Baltimore plant ruins 15M Johnson and Johnson coronavirus vaccines

#20
post #2

I wonder if those vaccines were primarily going to be distributed locally. I live nearby, and my county's weekly covid update said they expect to have most people 16+ vaccinated by the end of April because we're supposed start getting an increased number of vaccine doses every week.

"The error should not affect Johnson & Johnson doses currently being delivered and administered nationwide, as they were produced in the Netherlands. ... The Times says the accident won't stop the U.S. from reaching President Biden's goal of having enough vaccine by the end of May for every adult, but in the global race against the virus, every dose counts."

Won't affect vaccine delivery for Americans. Difficult to say for the rest of the world.

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