Earlier quoted context omitted.
Adam Neely released a pretty in-depth video recently with the opinion that Hey Joe is straight-forwardly in the key of E, as long as you don't get stuck trying to fit it into a diatonic, traditional Western framework. It's a good watch. https://www.youtube.com/watch?v=DVvmALPu5TU I had an unanswered question after the video -- are there listeners who don't feel that sense of "home" when arriving at the E chord? I cer…
I think context is important. If you are talking about guitar based music, then E is a pretty safe bet as home. But what if a group doesn’t use standard tuning? The first two examples that come to mind are Alice In Chains and Tool. They use E flat tuning and drop-d tuning, respectively (mostly). When I listen to them, Eb and D are home.
If someone plays it in another key, transposes it etc, it will still have a specific key, just transposed.
In this case of course it's about the Jimi Hendrix recorded cover version, not trying to get some key that would hold across all possible versions.