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Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

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Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#251

Post by dang »

idoubtit wrote: post #46

The current HN title deviates from the original title in a way that is misleading. "Vaccines Are Effective Against Covid Variants" is a wrong affirmation. The original article only states that in vitro experiments show that some vaccines are effective against some variants. Not all vaccines, not all variants, and no test on human beings. A counter point is that some vaccines seem to be ineffective agains some variant…

Ok, we've reverted the title now. Submitted title was "Vaccines Are Effective Against Covid Variants". Submitters: please follow the site guidelines, which ask "Please use the original title, unless it is misleading or linkbait; don't editorialize."

https://news.ycombinator.com/newsguidelines.html

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#253

Post by legulere »

timr wrote: post #119
legulere wrote: post #47

Earlier quoted context omitted.

That is just one factor though in which COVID-19 is worse than the seasonal influenza though. COVID-19 has a basic reproduction number of 3.3 – 5.7, while the seasonal influenza has one of 0.9 – 2.1 [1], which means that it spreads far more easily. You cannot just wait until summer for influenza season to be over. With influenza you have a higher rate of existing immunity in the population. With COVID-19 it is basica…

"Younger people are also more affected [2]" The paper you're citing says "younger" means 59, vs 66 for influenza: > Patients with COVID-19 were younger (median age [IQR], 59 [45–71] vs 66 [52–77]; P Also, this is data from a single hospital , across two different years. The overall trends for SARS-CoV2 are not even remotely debatable: the risk of mortality rises exponentially with age. It's one of the most striking f…

I just took the first study I could find. You seem to claim that it’s conclusions are wrong and that young people are less affected of COVID than influenza. Do you have good studies to back this up?

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#254

Post by oblio »

offby37years wrote: post #191
oblio wrote: post #178

Earlier quoted context omitted.

Who ever said 2 weeks? They serve the exact same role they did at the start. If we'd open stadiums now the exact same thing will happen, that happened 1 year ago. Lockdowns will continue until we either reach herd immunity naturally or through vaccines or we have a treatment/mitigation for the disease.

Every offical that was selling the initial lockdown. Just have to get the R0 below 1, remember? You really think the masses would have been OK with a year of lockdowns and the despair that entails up front? Your conclusions don't match reality. States like Florida have open stadiums and are fairing the same as states like California that insist on totalitarian overreach.

> States like Florida have open stadiums

With the exact same density as before ?

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#255

Post by inglor_cz »

oliwarner wrote: post #198
inglor_cz wrote: post #105

Earlier quoted context omitted.

"Of these, the vast majority (>99.9%) resolve with no major sequelae." Citation needed. > 99.9% is an extraordinary number and probably needs extraordinary support.

"99.9%" is usually what you see when people are talking about the numbers of people in their whole population who haven't died from it yet. I appreciate the problems in test data when talking about case-mortality, but population-mortality is utter nonsense. Not to mention that in many places the whole population-mortality is now more than 0.1%. 0.2% of the UK has died from Covid. A few places are worse than that, and…

Yes, including the Czech Republic, where I live. We have about 0,25% of the entire population dead from the Covid pandemics, one of the worst results worldwide, if not number 1...

So I was really interested in OPs sources.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#256

Post by yorwba »

Mediterraneo10 wrote: post #204
yorwba wrote: post #71

Earlier quoted context omitted.

> European, Asian, and North/South American supply chains are internally integrated. A truck driver transports goods from the Czech Republic to France and unloads them at the destination. But does that truck driver need to have direct contact with other people to do their job? Why can't they unload their cargo, sleep at a quarantine facility, and then drive a new truckload in the opposite direction, without an opport…

For a freight truck to cross Europe can take multiple days, especially as drivers are not allowed to drive more than 9 hours a day (all European trucks are outfitted with a tachograph) and in some countries they have to stop for all of Sunday. During those days on the road, drivers need to be able to stop and use a quality toilet and buy food, which generally means a petrol station. That is the existing infrastructur…

> That is the existing infrastructure – your vision of hermetically sealed, disease-free places to stop is simply unrealistic as considerable time and money would be needed to build these everywhere in Europe that a driver would need to stop.

All countries with quarantine facilities I'm aware of are using existing buildings. They don't have to be hermetically sealed, just ensure that people don't come into contact with each other inside.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#257

Post by sampo »

toolz wrote: post #236
Mediterraneo10 wrote: post #201

Earlier quoted context omitted.

Note however that Israel has closed its borders tightly, so Israel can't tell us much about the vaccines' effects on variants that haven't entered that country yet.

I've only seen reporting suggesting that every variant listed as a "variant of concern" from the CDC is present in Israel. So their data should be good.

> I've only seen reporting suggesting that every variant listed as a "variant of concern" from the CDC is present in Israel.

But not present in large numbers now, so we have to wait months before we'll know if they'll be able to spread in the vaccinated population or not.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#258

Post by oliwarner »

irq11 wrote: post #230
sdenton4 wrote: post #142

Earlier quoted context omitted.

That was the "let me Google that for you" response to your own completely unsupported claim. It seems like you're unwilling to look at evidence contrary to your opinions; the 'debate' is amongst deniers who aren't looking at evidence. I suggest some self reflection is in order; you're arguing with the same tactics as a climate change denier. https://www.health.harvard.edu/blog/the-tragedy-of-the-post-... https://en.m…

You’re making the claim. Prove it. Don’t give me an editorial. Don’t give me a wikipedia page. Link to the controlled studies, showing the widespread damage that you’ve claimed. You can’t, because they don’t exist. You linked to the best there is, and it doesn’t rise to any reasonable standards of scientific evidence. Self-reported data is almost worthless. Uncontrolled , self-reported data is worthless. I’m perfectl…

I'm sorry to hear your search engine got a flat tyre. Belligerently sniping about exactly what it is you want us —your research assistants, seemingly— to hand deliver you, doesn't seem like the best way to retain karma here, let alone have a discussion about something...

But anyway, some more material for you.

https://www.medrxiv.org/content/10.1101/2020.10.19.20214494v... https://www.bmj.com/content/370/bmj.m3026

It's going to be many years until we have a proper handle on this. Until then you might have to be willing to accept a flood of more anecdotal field data as having some analytical value.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#259

Post by icedchai »

SpicyLemonZest wrote: post #247
icedchai wrote: post #231

Earlier quoted context omitted.

If you told people in March, 2020, that this would still be going on over a year from now, and likely 18+ months from now, what do you think the reaction would be? "You're crazy"??? Trump was talking about "reopening" things for Easter last year. He should've said Easter, 2022. I was looking back at some old texts from a friend, last year around this time... "I hope this isn't going on 6 months from now." People want…

There are already areas of the country where "this" isn't going on, where businesses are open at full capacity and the public is happy to patronize them. Even in the most socially distanced areas, there's lots of people going on vacations and eating in restaurants and having house parties with their friends and family. So when you talk about reopening in Easter 2022, it's hard to connect that with the state of things…

We will absolutely see another surge before the vaccine roll out is completed. So tens of thousands of more people will die because states reopened too quickly.

Easter, 2022 is no more realistic than Easter, 2020. Expectations need to be set that are reasonable and err on the side of caution and pessimism.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#260

Post by postalrat »

halfmatthalfcat wrote: post #248
postalrat wrote: post #246

Earlier quoted context omitted.

Did you just reply to the wrong comment? I didn't say anything about masks.

Your comment wasn't constructive and at worst, sounded like you were making light of mask wearing by suggesting we should just never leave our houses. Of course if everyone was confined to their houses, there would be less sickness but nobody is debating that. We're debating the normalization of mask wearing.

It sounds like your concern is masks, not saving lives. Because if you care more about saving lives you will realize people only need to stay home. Fewer fatal accidents, infections, and other disturbances if people just never ventured outside their homes.
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