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Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

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Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#151

Post by kweinber »

ttul wrote: post #23
carbocation wrote: post #18

The title of this article, which performs an in vitro test, is "Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination". The editorialization in the current Hacker News headline ("Vaccines Are Effective Against Covid Variants") is not warranted.

If I can pass on what I’ve learned in the past 12 months as a newly minted virus enthusiast whose peak education in the area was human physiology 101: “In vitro” means testing outside of the human body. Just because a result is confirmed in vitro does not mean it will be replicated when tested “in vivo” (in the actual human).

In vitro literally means “In glass” (like in a test tube). In vivo means “in life” (like IRL)

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#152

Post by arcticbull »

offby37years wrote: post #148
dekerta wrote: post #146

Earlier quoted context omitted.

That's a nice quote, but still doesn't answer the question. No government in their right mind wants to continue lockdowns unnecessarily. Lockdowns cost a lot of money and make a lot of voters angry

Lockdowns were just meant to be for two weeks to “flatten the curve”, remember?

Unfortunately pesky reality got in the way.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#153

Post by [deleted] »

offby37years wrote: post #148
dekerta wrote: post #146

Earlier quoted context omitted.

That's a nice quote, but still doesn't answer the question. No government in their right mind wants to continue lockdowns unnecessarily. Lockdowns cost a lot of money and make a lot of voters angry

Lockdowns were just meant to be for two weeks to “flatten the curve”, remember?

[deleted]

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#154

Post by dbetteridge »

paulmd wrote: post #50
amelius wrote: post #3

Earlier quoted context omitted.

That's wrt mild to moderate cases. It might still be effective against severe cases.

nevertheless, you have to actually support that hypothesis with research. Just the fact that it's ineffective against mild to moderate doesn't mean it will be effective against more severe cases. it might also be ineffective against severe cases, making it just entirely ineffective against those strains. a year later and people are still trying to twist studies into support of their favored medical treatments without…

It is being worked on, animal studies only so far with human studies to come as SA rolls out their 100k doses of AZ I am sure.

Animal model study - Syrian hamsters https://academic.oup.com/cid/advance-article/doi/10.1093/cid...

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#155

Post by bzzt »

dekerta wrote: post #146
offby37years wrote: post #138

Earlier quoted context omitted.

“Power tends to corrupt, and absolute power corrupts absolutely” — John Dalberg-Acton

That's a nice quote, but still doesn't answer the question. No government in their right mind wants to continue lockdowns unnecessarily. Lockdowns cost a lot of money and make a lot of voters angry

Well, in Germany three politicians who had to resign because of corruption where they had made deals with companies manufacturing masks and made hundreds of thousands of euros. And this is just facts and no conspiracy theories, and I bet this goes on at every level. If you find a way to (legitimately) control people and peoples behaviours, of course it's lucrative.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#156

Post by davak »

This was not testing against the South African and Japan/Brazil variants that are much more likely to escape vaccination antibodies. This UK variant is mostly problematic against the unvaccinated.

In the lab the South Africa and Japan/Brazil variants have severe reduction in neutralizing antibodies which is very concerning for vaccine escape. That being said, we don’t have a great way to test for T cell and other immunity which also plays a role. Getting the vaccine decreases severity of illness regardless of the variant.

The answer is get any vaccine as soon as possible. Then get the booster too when it’s available.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#157

Post by WalterBright »

simonh wrote: post #140
WalterBright wrote: post #131

Earlier quoted context omitted.

> Are vaccinated individuals still able to host and transmit the virus, despite not contracting the disease caused by the virus? If that is the case, herd immunity cannot be achieved with vaccinations.

Even if vaccinated people can contract the virus, they are likely to fight it off relatively quickly and keep the virus load in their bodes low, keeping their chances of transmitting it much lower than an unvaccinated person would. Lets say being vaccinated halves your chances of passing on the virus compared to an unvaccinated person. If almost all the population get vaccinated, we can ease the lockdown to the point…

But if the vaccines don't prevent infection, you won't achieve herd immunity until 70% have been infected one way or another.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#158

Post by brandon272 »

ta8645 wrote: post #14

This is good news. Now maybe Fauci should rethink his idea that people need to wear their masks for another year even after getting vaccinated. One of his reasons was because of worry about the variants.

It’s bizarre to me that so many people seem to equate not having to wear a mask as the ultimate return to normal.

Mask wearing is probably the least invasive, least inconveniencing thing that we have been asked to do throughout this pandemic, yet half the population acts as if it is the equivalent to being handcuffed to a steel post in their basement.

If health officials said “after being vaccinated, do whatever you want, please just wear a mask for the next year and wash your hands while we monitor efficacy”, that would be a success story with respect to returning to normal, to me at least.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#159

Post by raphaelj »

timerol wrote: post #110
idoubtit wrote: post #20

Earlier quoted context omitted.

If I'm not mistaken, the rate in the paper is bigger, 0.25% against 22k/11M = 0.20% in Belgium. But if the newspaper I read are right, there is a catch: when tests were not available, Belgium counted as a covid death every case where it could be suspected. Even nowadays, in case of comorbidity, covid is always written down as the cause of death. So 22k is probably a maximum, and, taking into accound the 25% uncertain…

I think you're misreading the comment you replied to. "+/- 25% of a 11M of the population having been infected" means about 25% of 11M, or 2.75M, officially infected. 22k/2.75M would imply a 0.8% fatality rate.

Exactly.

And with respect to the counting, it seems like the Belgian numbers more of less match the reported excess deaths in 2020 within 10% [1].

[1] https://www.medrxiv.org/content/10.1101/2021.01.27.21250604v...

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