Live data from Hacker News

Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

jamanetwork.com

61–70 of 267 posts

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#61

Earlier quoted context omitted.

> Keep wearing your masks and social distancing people. It’s hard, it’s a sacrifice, but together we can conquer this disease and return to life “as normal”. This ghost is not going back into the bottle. It's way too widespread for that now. Even the WHO has determined that. Even if one country manages it, some tourist will bring it in. The vaccines don't stop the spread enough either to kill it completely. People wi…

The vaccines appear to be plenty effective enough to stop the spread, if enough people get them. We don't have great information about the variants, but the big improvements in Israel and England are encouraging, even with vaccination still ongoing.

Well I will get the vaccine as soon as I can get it (which is not very soon, sadly). I'm not anti-vax, but the last few weeks the news has been all about "Don't be surprised if people still get COVID after being vaccinated". Like here: https://news.ycombinator.com/item?id=26522853

With that in mind I don't think eradication will be achievable. It only takes one person with a resistant mutation. I think we can hope to bring it under control. But not eradicate it.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#62

For people arguing that not being part of a risk group is a reason not to protect yourself, please take a lesson from brazil. Being part of a 'high risk group' does not saves you from infecting other people who are part of such groups. That's basically what happened in brazil: people who were not part of risk groups crowded, encouraged by the president himself[0][1][2]. The number of infected poeple soared and varian…

Also for selfish reasons. I know a 24 year old ballerina (so a professional athlete) who had it two months ago and is now at 80% lung capacity.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#63
post #54

Earlier quoted context omitted.

Hawaii, the only state that requires a COVID test within 36 hours of flying there? I mean, of course they'd have the lowest cases per capita when they're the only ones actively refusing entry to those who have it.

Almost like having strong borders is useful. Not a very compelling argument when the same people most in favor of Covid restrictions also spent five years calling Republicans the devil for wanting to reinforce our borders. Also the US has open borders between states on the mainland. Any individual state besides Hawaii never had even the possibility of isolating themselves.

What does building a wall have to do with policies to prevent the spread of contagious diseases? Jack squat.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#64
post #59
post #55

54 patients total? That's not a sample size to draw strong conclusions on :(

Assuming normal distribution, the law of large numbers kicks in at n=30.

The actual number of examined vaccinated people('s serum) is 14. The other 20+20 are acute/recovering cases. (I was being generous with the 54.)

Also the page itself says Limitations include the small sample size under "Discussion".

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#65

Earlier quoted context omitted.

Hawaii, the only state that requires a COVID test within 36 hours of flying there? I mean, of course they'd have the lowest cases per capita when they're the only ones actively refusing entry to those who have it.

How many entry points does Hawaii have compared to the average state? How do those points of entry compare in terms of staff and systems to operate those restrictions? Hawaii gets a lot more mileage out of its restrictions than Iowa is going to do. We can acknowledge these differences without conceding that restrictions aren’t worth the squeeze; it just means that New Zealand isn’t a good reference point.

A fair number of states did have travel restrictions in place but there were oodles of exceptions and AFAIK no real enforcement although it probably did limit cross-border travel some.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#66
post #13

Earlier quoted context omitted.

For every person that dies (an agonizing death akin to medieval torture), a few more are in intensive care fighting for their lives. For every one of those, others end up in the hospital, spread the disease to others, suffer from “long covid”, or merely suffer greatly. Every person that gets covid adds to the likelihood the disease will become uncontrollable in the long term and endemic. Keep wearing your masks and s…

I don’t see any reason new variants would ever stop coming. What are you proposing is the end point of all of this?

Regular vaccinations, just like the flu

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#67

Earlier quoted context omitted.

Some more: > Indiana's IFR for noninstitutionalized persons older than 60 years is just below 2% (1 in 50). In comparison, the ratio is approximately 2.5 times greater than the estimated IFR for seasonal influenza, 0.8% (1 in 125), among those aged 65 years and older (5).

That is just one factor though in which COVID-19 is worse than the seasonal influenza though. COVID-19 has a basic reproduction number of 3.3 – 5.7, while the seasonal influenza has one of 0.9 – 2.1 [1], which means that it spreads far more easily. You cannot just wait until summer for influenza season to be over. With influenza you have a higher rate of existing immunity in the population. With COVID-19 it is basica…

I wasn’t comparing it to anything. I was just writing more of the studies findings.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#68

Earlier quoted context omitted.

The vaccines appear to be plenty effective enough to stop the spread, if enough people get them. We don't have great information about the variants, but the big improvements in Israel and England are encouraging, even with vaccination still ongoing.

Not sure why the GP is being downvoted. SARS-CoV-2 will most likely become endemic. [1] https://science.sciencemag.org/content/370/6516/527.full

> Should reinfection prove commonplace, and barring a highly effective vaccine delivered to most of the world's population, SARS-CoV-2 will likely become endemic.

The thing is, we don't know if reinfection will prove commonplace. We don't know how long immunity will last given a two-shot regimen—though the strong immune response that people are having on the second shot might be cause for hope. We don't know how the virus will mutate on it's point/spike, the main infection vector that the RNA vax target. We just don't know.

Research is emerging, time will tell. In the meantime, it's fear mongering.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#69
post #38

Earlier quoted context omitted.

> For every person that dies (an agonizing death akin to medieval torture) I think this is wrong, at least in rich countries, at least those that are sane enough to cure their ill citizens. A friend of mine died of covid last year. Then a family member this year. They were both sedated, and did not suffer at all on their last days in hospitals.

Sedation is death with a respiratory illness like this. How were they feeling before they were sedated? Probably like they’d been drowning for hours. For all intents and purposes, that was the end of their life as far as their experience of it. Don’t get me wrong, it’s great that we can provide palliative comfort for those final hours/days. But it doesn’t tell the full story.

Just for clarity/augmentation/pedantic detail: you might be sedated and end up an a ventilator.

But ventilators are really bad for COVID survival and really a last ditch, long-shot chance try to salvage your life. Practitioners hold off on the sedation and associated required ventilation as long as possible to try and spare your life.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#70
post #24

Earlier quoted context omitted.

So you’d prefer we be like Brazil? Because the alternative for us was not Taiwan or Korea. They went far and beyond what Americans were willing to tolerate. Never mind the bad statistics behind your claim that covid is no worse than the flu. A athlete friend of mine in his 20s has permanent heart damage caused by the virus. Covid-19 is not a joke, no matter how much you wish it was. Americans could be out free, today…

There aren't only americans on this site. FWIW as a european (Belgium resident), your statement doesn't apply. Belgium did a shitty job since the second wave: We didn't go far enough and only applied a weak lockdown which has been in effect since October . So life here has been just bad enough to test everybody's patience for about six months. And now we're in a new uptick and everyone's losing their shit. Korea mean…

All EU countries screwed up, not just Belgium. Case in point, German states agreed on an "emergency brake" once cases increase over 100 per 100k, 7 day average. Now we are there, 3 days in a row. So, one would assume they would close schools again. No, because it has to be 3 days in a row, weekends don't count so. After that, two days to implement measures. Which means schools will be open next week despite a heavy case load. Only to fulfill the political goal of opening schools before Easter. Nevermind we will close down everything after Easter through April.

There is no strategy, no planning, no logic involved.

Post reply on HN