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Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

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Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#3

It seems that the AstraZeneca vaccine is not effective against the South African variant [0]. [0]: https://www.nejm.org/doi/full/10.1056/NEJMoa2102214?fbclid=I...

That's wrt mild to moderate cases. It might still be effective against severe cases.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#4
The plural ‘variants’ in the title is a bit misleading. Only one of the four viruses they tested is one we are actually concerned about at this time. The first is the original virus, which was displaced by the second early in the pandemic and against which vaccines are already known to be effective. The third one is the UK variant, which is of interest and the fourth is an artificial virus with a single mutation of interest, which doesn’t circulate in nature. This is all good but the study doesn’t add anything that wasn’t already known. It appears that better funded groups at the NIH, UTMB, Fred Hutch and Columbia beat them to the goal and to publication in the even more prestigious publications like NEJM and Nature. In any case, reproducing important research is a laudable and underrated goal. However, I would suggest a more modest title - ‘Study adds to data for vaccines’ effectiveness against the UK variant of SARS-COV-2’.

There are other variants - Brazilian, South African, Californian, New York, etc - which need to be studied in more detail. There are already data from the aforementioned research groups for at least some of these variants that suggest that vaccines will continue to be at least partially effective.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#5
Thanks for sharing this. I actually see very little reporting on how this virus spreads among the vaccinated population. I would love to see new case numbers broken down by vaccinated and not-vaccinated people from countries like UK, US and Israel. So far I’m unable to find such data on the internet.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#6
post #3

It seems that the AstraZeneca vaccine is not effective against the South African variant [0]. [0]: https://www.nejm.org/doi/full/10.1056/NEJMoa2102214?fbclid=I...

That's wrt mild to moderate cases. It might still be effective against severe cases.

They didn’t design the study to look for severe cases in South Africa and this variant isn’t widespread in other countries where the vaccine is in use, so it will be hard to get evidence on effectiveness against severe disease anytime soon.

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#8
post #5

Thanks for sharing this. I actually see very little reporting on how this virus spreads among the vaccinated population. I would love to see new case numbers broken down by vaccinated and not-vaccinated people from countries like UK, US and Israel. So far I’m unable to find such data on the internet.

This post seems like it might be the closest to what you are looking for: https://www.reddit.com/r/COVID19/comments/loljxz/effectivene...

Re: Neutralizing antibodies against SARS-CoV-2 variants after infection, vaccination

#9
post #7

A January 2021 study in the annals of internal medicine estimating the death rates of non institutionalized patients of .26 percent with age breakdowns . https://www.acpjournals.org/doi/10.7326/M20-5352?utm_source=...

Some more:

> Indiana's IFR for noninstitutionalized persons older than 60 years is just below 2% (1 in 50). In comparison, the ratio is approximately 2.5 times greater than the estimated IFR for seasonal influenza, 0.8% (1 in 125), among those aged 65 years and older (5).

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