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Scientist behind Covid-19 mRNA vaccine says her team's next target is cancer

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Re: Scientist behind Covid-19 mRNA vaccine says her team's next target is cancer

#41

Post by snowwrestler »

adrianmonk wrote: post #37
arrosenberg wrote: post #11

Earlier quoted context omitted.

It sounds like you are conflating the antiviral implementation with what the mRNA technology itself is doing. mRNA acts as a blueprint for proteins. Your body has tRNA translation complexes that "read" the mRNA and appropriate the correct amino acid to add to the protein chain. Here is a more detailed description - translation begins about halfway down with the UGCAs: https://www.nature.com/scitable/topicpage/transla…

> I could imagine a number of different approaches - targeted inducing of cell death, "painting the target" for chemo drugs, making things like monoclonal (designer) antibodies in-vivo, etc. The article does explicitly call it a "cancer vaccine" (direct quote from the researcher) and says "the same principle [as the COVID-19 vaccine] can be applied to get the immune system to take on tumours". That's more specific th…

Scientists are already showing some promising results using the immune system against tumors. See for example:

https://en.m.wikipedia.org/wiki/Pembrolizumab

The promise of mRNA is the potential to prompt the body to produce the therapeutic antibodies itself, rather than produce them externally and injecting regularly.

Re: Scientist behind Covid-19 mRNA vaccine says her team's next target is cancer

#42

Post by bryanlarsen »

thepangolino wrote: post #30
bryanlarsen wrote: post #5

Earlier quoted context omitted.

> so received limited focus on that until SARS-COV-2 Or more accurately, until Bill Gates invested and retargeted them at vaccines. These investments predated Covid19 and were in 2015 and 2019.

I’m pretty sure the SARS-CoV-2 mRNA vaccines are based on mRNA vaccine research for the original SARS virus. The only reason that one wasn’t finalised is that the epidemic sort of died out on its own.

Which is why Bill Gates gave them money to continue that work.

IIRC it only took them about 3 weeks to create the vaccine. To work that fast they had to have had a good base to work from, the infrastructure to do so, knowledge and experience.

Re: Scientist behind Covid-19 mRNA vaccine says her team's next target is cancer

#44

Post by doggodaddo78 »

jfengel wrote: post #3
vibrio wrote: post #2

"next target"? has been a target since inception. At Moderna or BioNtech Cancer and Gene Therapy were priorities during the last decade or so, with limited evidence of success as far as I can tell. Infectious disease is scientific low hanging fruit for this approach, but has been less attractive commercial opportunities, so received limited focus on that until SARS-COV-2. The did a good job executing on the vaccines,…

Now that it's been proven and the manufacturing scaled, there may be a fair bit of profit in it. If tuberculosis, MRSA, and even malaria can be targets, that would be world-changing. I'm not even sure how "cancer" is really a target -- are they talking about individualized treatments for your specific cancer cells?

That's what it sounds like. Possibly safer and simpler than viral immunoconological vectors. I guess the issue is identifying the very specific histological anomalies in cancer cells to target SARS-CoV-2-spikes style. Perhaps this can be done by flow cytometry and sequencing of healthy cells vs. cancer cells. The big challenge is making certain no other cells share the targeted structures.

Re: Scientist behind Covid-19 mRNA vaccine says her team's next target is cancer

#45

Post by capnkap »

thelazydogsback wrote: post #43

Anyone more knowledgeable than myself following any of the research saying that the mRNA vaccines can be dangerous due to over/mis-expression, such as: https://carterheavyindustries.files.wordpress.com/2021/02/co...

I'm not certain that anyone should be taking a "scientific paper" seriously that concludes with:

> Many have raised the warning that the current epidemic of COVID-19 is actually the result of an bioweapons attack released in part by individuals in the United States government

Also, a bit about the author: https://en.wikipedia.org/wiki/J._Bart_Classen

Re: Scientist behind Covid-19 mRNA vaccine says her team's next target is cancer

#46

Post by graeme »

thelazydogsback wrote: post #43

Anyone more knowledgeable than myself following any of the research saying that the mRNA vaccines can be dangerous due to over/mis-expression, such as: https://carterheavyindustries.files.wordpress.com/2021/02/co...

Not plausible. Paper has no citations and is by an author who is anti-vaccine in general. Absolutely no other discussion of such a possibility in the field.

https://sciencebasedmedicine.org/can-mrna-based-covid-19-vac...

Re: Scientist behind Covid-19 mRNA vaccine says her team's next target is cancer

#47

Post by standardUser »

thelazydogsback wrote: post #43

Anyone more knowledgeable than myself following any of the research saying that the mRNA vaccines can be dangerous due to over/mis-expression, such as: https://carterheavyindustries.files.wordpress.com/2021/02/co...

These people, some who are credentialed, seem to think this is a garbage paper. https://www.reddit.com/r/bioinformatics/comments/kfv7ci/coul...

Re: Scientist behind Covid-19 mRNA vaccine says her team's next target is cancer

#48

Post by thelazydogsback »

capnkap wrote: post #45
thelazydogsback wrote: post #43

Anyone more knowledgeable than myself following any of the research saying that the mRNA vaccines can be dangerous due to over/mis-expression, such as: https://carterheavyindustries.files.wordpress.com/2021/02/co...

I'm not certain that anyone should be taking a "scientific paper" seriously that concludes with: > Many have raised the warning that the current epidemic of COVID-19 is actually the result of an bioweapons attack released in part by individuals in the United States government Also, a bit about the author: https://en.wikipedia.org/wiki/J._Bart_Classen

Yeah. I couldn't find the other articles I was looking for. His US bioweapon theory is pretty silly.

As for "anti-vaxers", though I don't count myself as one or probably agree politically with most of them, I'm going withhold complete judgment there - vaccines are obviously effective, but until there are actually epidemiologically valid multi-generational meta-studies with as many confounding factors as as possible removed (probably requiring placebos be given to a percentage of people) I'm not sure we can separate vaccines from other relatively novel environmental or behavioral factors that may lead to certain diseases, esp. developmental/neurological conditions. I now have a bit less knee-jerk anti-anti-vax attitude after sitting at a table with several doctors who admitted they didn't/wouldn't follow all vaccine protocols with their own children - but I know this is certainly not scientific evidence. But I'll certainly be getting the COVID vaccine when I'm eligible...

Re: Scientist behind Covid-19 mRNA vaccine says her team's next target is cancer

#49

Post by thelazydogsback »

graeme wrote: post #46
thelazydogsback wrote: post #43

Anyone more knowledgeable than myself following any of the research saying that the mRNA vaccines can be dangerous due to over/mis-expression, such as: https://carterheavyindustries.files.wordpress.com/2021/02/co...

Not plausible. Paper has no citations and is by an author who is anti-vaccine in general. Absolutely no other discussion of such a possibility in the field. https://sciencebasedmedicine.org/can-mrna-based-covid-19-vac...

Thanks for the link

Re: Scientist behind Covid-19 mRNA vaccine says her team's next target is cancer

#50

Post by thelazydogsback »

standardUser wrote: post #47
thelazydogsback wrote: post #43

Anyone more knowledgeable than myself following any of the research saying that the mRNA vaccines can be dangerous due to over/mis-expression, such as: https://carterheavyindustries.files.wordpress.com/2021/02/co...

These people, some who are credentialed, seem to think this is a garbage paper. https://www.reddit.com/r/bioinformatics/comments/kfv7ci/coul...

Thanks - I'm going to take these references back to the person who sent me the original article
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