Vaccines should end the pandemic, despite the variants, say experts
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Re: Vaccines should end the pandemic, despite the variants, say experts
#2So also the digitalizzation and 4th industrial revolution will end... Let's hope to don't see the army on the street before 2026
Re: Vaccines should end the pandemic, despite the variants, say experts
#3This is a hopeful but possible take. But the 501Y.V2 (B.1.351) and 501Y.V3 (P1) lineages have the mutation within the conserved region for coronaviruses near the spike protein cleavage site. These show massively (1000x) decreased monoclonal antibody binding for original genetic sequence designs. It's better for the mRNA vaccine produced human-body-made antibodies which show only 5-10x reduction in binding.
But antibody binding isn't the full story and there may be T-cell stuff helping too. The data seems to indicate updated spike protein designs will be needed but if there's other stuff going on we don't know about old spike vaccines could still work. I can't say it will definitely help because the vaccine rollout is so slow and air travel is so fast that this negative pressure will probably provoke more variants as long as host numbers remain high.
ref: "Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7" [pdf] https://www.nature.com/articles/s41586-021-03398-2_reference... https://i.imgur.com/8co1IoL.jpg "SARS-CoV-2 VoC B.1.1.7 and B.1.351 neutralization evasion" table.
https://covariants.org/variants/S.501Y.V2 https://covariants.org/variants/S.501Y.V3
Re: Vaccines should end the pandemic, despite the variants, say experts
#4These kind of pandemic tend to end themselves after about 20-30 months. We’re about half way there anyway.
Re: Vaccines should end the pandemic, despite the variants, say experts
#5So also the digitalizzation and 4th industrial revolution will end... Let's hope to don't see the army on the street before 2026
Why the FUD?
Re: Vaccines should end the pandemic, despite the variants, say experts
#6These kind of pandemic tend to end themselves after about 20-30 months. We’re about half way there anyway.
Citation needed.
Re: Vaccines should end the pandemic, despite the variants, say experts
#7These kind of pandemic tend to end themselves after about 20-30 months. We’re about half way there anyway.
Which other pandemic do you think is even remotely comparable to Covid-19? (All pandemics with a comparable transmission rate happened in times that simply aren't comparable to the modern world in terms of mobility, which obviously affects the way this goes.)
Re: Vaccines should end the pandemic, despite the variants, say experts
#8This is a hopeful but possible take. But the 501Y.V2 (B.1.351) and 501Y.V3 (P1) lineages have the mutation within the conserved region for coronaviruses near the spike protein cleavage site. These show massively (1000x) decreased monoclonal antibody binding for original genetic sequence designs. It's better for the mRNA vaccine produced human-body-made antibodies which show only 5-10x reduction in binding. But antibo…
Thank you for the references!
Re: Vaccines should end the pandemic, despite the variants, say experts
#9>Galit Alter, professor of medicine at Harvard Medical School and the Ragon Institute of MGH, MIT, and Harvard, said the fast-spreading U.K. variant seems able to evade some vaccine protection, and the South African variant appears able to skirt even more. Despite that, she said, none have completely escaped the body’s post-vaccination immune responses.
Weak on facts and strong on persuasive language:
>seems able to evade
Either they can evade or they can't, there's no seeming to about it!
>appears able to skirt even more
Either it can skirt around or it can't, there's no appearing about it!
And anyway, herd immunity to these kinds of viruses comes from full-blown exposure - not hiding behind a vaccine.
After all is said and done, this is all about money and power - a great pile of public money and the opportunity to concentrate the power to run countries in the hands of a few for as long as possible.
And then too, the opportunity for academicians to puff their CVs and to ensure their place in the sun of scholarly tenure and advancement.
I rest my m'lud.
Re: Vaccines should end the pandemic, despite the variants, say experts
#10This is a hopeful but possible take. But the 501Y.V2 (B.1.351) and 501Y.V3 (P1) lineages have the mutation within the conserved region for coronaviruses near the spike protein cleavage site. These show massively (1000x) decreased monoclonal antibody binding for original genetic sequence designs. It's better for the mRNA vaccine produced human-body-made antibodies which show only 5-10x reduction in binding. But antibo…
How does a 5x reduction in binding actually impact infection?