For me, while I'm glad I went, I'm shy around strangers so it was extremely lonely. If I did it backpacking and staying in hostels I'm sure I'd have met people in the hostels but in my mid-40s, hostels are no longer in my comfort zone.
Further, it was not remotely the same as taking a vacation. On vacation if you're into shopping you can shop. But, traveling the world means you can't really shop because you have to carry everything you own. That might be a good thing but, at least in my experience, shopping is some not insignificant part of vacations for many people and removing that as an activity lowered some of the enjoyment.
Another issue for me was always having to think about where to be next. In other words I'd arrive at some new place and immediately need to book the next place or else I'm homeless in a week or 2 when this place runs out.
Yet another was basically seeing the same things over and over. Every city in Europe has yet another church, another contemporary art museum with the same 15 artists as the last one, etc... Of course most cities have their unique charm and I'm glad I went to every one of them but, ... I did get tired of certain things as they came one after another (churches and museums).
Another other issue is you're unlikely to have friends (or rather I didn't). Your friends are back at the place you used to live and they have their own lives and you're no longer part of that life as much as you might wish you were. Maybe it's better to say you won't have hangout buddies, at least not if you're doing it alone.
After 3 years I got an apartment again and have been in it for 4.5 years. I still take 3-4 vacations/trips a year though (well except not in the last 12 covid months).
I saw some social scientist claimed it's best to take more short vacations than longer ones because after N days where N was less than 7 or so you get used to it. No idea if their research replicates.
Something I'd suggest is looking up meetups and/or hackathons or certain types of other events where you might make new friends. I made a bunch of friends in Berlin by attending "Talk & Play", a game dev event. I've been back 2 more times since then to see the friends I made their. Of course it might be hard to find an English speaking meetup. You can check out Internations.org (not sure if they are good or bad but went to one meetup which was good)