41–50 of 85 posts
Related (oral related to gut that is)? Over 140k virus species in the human gut, half of which are new to science https://news.ycombinator.com/item?id=26389397
Earlier quoted context omitted.
There's Cavibloc, which is supposed to reduce cavity-inducing bacteria. It was developed at UCLA. There's also CloSYS, which is basically a highly diluted bleach that clears your mouth of bacteria. It is ADA approved. There's also Xylitol, which is also supposed to help reduce bad bacteria. I've been using all of these for the past year, and my most recent dental cleaning had almost no tartar buildup, which is really…
> but some of her claims have been controversial among other dentists. I have a lot of dentist family and friends. Anything that isn't "drill and fill" is controversial to them. :) Dental school these days seems to really stress that everything must be treated with intervention by a dentist that happens to bring money to their practice. They are also super frightened of new technology. There was a technology that was…
Are you guys depleting host or enriching microbial? Are you analyzing the data as a composition via log contrasts? Are you using available pipelines (kraken, metaphlan, etc) or something custom? Any plans on doing a functional pathway analysis (ie. humann pipeline) on top of the microbial analysis?
Great questions! We implement a host-depletion step in both the wet lab, to increase sequencing depth of the microbiome, and dry lab. You may be concerned about potential bias introduced, and we've done some extensive research with our depletion and sequencing methods to reduce the cost of the test while also maintaining integrity of the microbiome profiles. Regarding pipelines: we use a custom pipeline that is simil…
Interesting that there are no commercial 'probiotics' for children onward to adulthood.
Earlier quoted context omitted.
> but some of her claims have been controversial among other dentists. I have a lot of dentist family and friends. Anything that isn't "drill and fill" is controversial to them. :) Dental school these days seems to really stress that everything must be treated with intervention by a dentist that happens to bring money to their practice. They are also super frightened of new technology. There was a technology that was…
Well said! Incumbents in the space have a lot to gain from the status quo of "drill, fill, and bill". This has limited the adoption of new diagnostic technology and advances in preventive health. We hope to eventually replace observational screenings that detect the onset of irreversible symptoms with early detection and interventions that prevent disease altogether.
I wonder if she'd have useful input on your product. Of course, she's trying to promote her own stuff (she sells Xylitol mints) but she also advocates for OTS treatments like Listerine.
Is there an email list I can get on to notify me? If not, please post again when you're ready to accept orders.
I really want to do this (sounds really cool!) but the signup page here really rubs me the wrong way, I don't feel comfortable giving out my card info to be charged at some undetermined time in the future. Is there an email list I can get on to notify me? If not, please post again when you're ready to accept orders.
Given we are offering this test for a limited time, we cannot make any promises on how much longer it will be available to the public. If you would like to stay updated on future product releases, you can sign up for the email newsletter at the bottom of our website. Hope that helps!
Interesting that there are no commercial 'probiotics' for children onward to adulthood.
Definitely! There's still a lot of unknowns in the microbiome space, and it's something we hope to look into as we gather more data. Some studies have suggested that adolescent oral microbiome profiles can serve as indicators of future health outcomes. Review here: https://pubmed.ncbi.nlm.nih.gov/32350240/
Do you look for specific non-dental disease factors, such as microbes that can lead to damage to the heart valves? What about signs of oral cancers (would those be strained out in the process of rejecting the human cells?)