Do you mean get hired, or do you mean keep doing research? Consider Alexander Shulgin: http://en.wikipedia.org/wiki/Alexander_Shulgin#Life_and_care... A bit of a hero in the bio-chemistry world. He was working at DOW chemical, and when he was assigned to a project that he wasn't interested in, he quit, and continued doing research and publishing from his house. There is a lot of research to be done in the fields of c…
Your average Joe won't have those kind of connections, or even access to current literature, which rather limits you to certain fields (i.e. not anything biology, chemistry or probably physics).