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Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

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Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#81

Post by flaviuspopan »

ahstilde wrote: post #79
flaviuspopan wrote: post #77

Congrats on an awesome launch homie :) My brother is severely disabled and I've always hoped he could have a companion dog but he's severely allergic. This very well could changes things. Cheers to a hella bright future.

Hi bud! Can't wait to see you in person after everything returns to normal. If I can help with your brother, let me know.

Much appreciated! I'll talk to my mom about it and see if she'd be down to try it for him. He's been exceptionally reactive to vaccines and allergens so there may be some hesitation. If you have any info about this therapy being used by people with autism, mental disabilities, etc. hook me up.

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#82

Post by flaviuspopan »

ahstilde wrote: post #79
flaviuspopan wrote: post #77

Congrats on an awesome launch homie :) My brother is severely disabled and I've always hoped he could have a companion dog but he's severely allergic. This very well could changes things. Cheers to a hella bright future.

Hi bud! Can't wait to see you in person after everything returns to normal. If I can help with your brother, let me know.

Also, is it a one-size-fits solution for dog allergens or does it vary by breed?

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#83

Post by billh »

ahstilde wrote: post #70
TheBlerch wrote: post #69

Congratulations Aakash and Manan on your launch! Talk about addressing an actual, physical pain point. Best of luck unstuffing the nation. A few questions: 1) How many months treatment time is necessary to see recognizable results? 2) How soon after starting Wyndly treatment can users stop using antihistamines such as anti-histamine pills and inhalers? 3) Generally how long must treatment be maintained before it can…

Thank you! Patients see improvement in symptoms after 6 months, with some patients reporting improvement as soon as 6 weeks. For most patients, this means they can stop taking their antihistamines. You mentioned inhalers. While there has been connection between allergy immunotherapy and asthma, allergy immunotherapy is not a replacement for your asthma inhaler. If a patient stays on drops for 5 years, they can expect…

Do you have a patient transition plan in place in the unfortunate case of Wyndly dissolving or a contingency for continual treatment for the duration of the 5 years?

It seems that it would be rather difficult for a patient to transition to another providers care on their own given how few doctors are working with SLIT.

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#84

Post by tpurves »

Shoop wrote: post #19
djyaz1200 wrote: post #10

Congrats on your launch! This sounds really promising! How do you deal with the risk of severe reactions? Is that risk diminished with drops instead of shots? I'm undergoing shot therapy now and had a life threatening anaphylactic reaction to a shot just a couple months ago. I'm concerned if I had been by myself at home I may have died? I was at the doctors office but they still called 911 for "backup" because I got…

Based on this video [1] linked in the OP, it seems like one of the big benefits is that anaphylaxis is not a side-effect of the drops. [1] https://www.youtube.com/watch?v=TpP41WQ6pBc

My understanding would be that Ananphylaxis can never ve a zero risk for severe allergies. After all, most anaphylaxis is triggered by accidentally eating an allergen or a tiny cross-contamination with an allergen. Everything depends on sensitivity of your allergy. I am excited about this startup, because we've been researching OIT (oral immunotherapy) treatment for my daughter who has multiple life-threatening allergies. My understanding is that oral therapy is only just beginning to be approved in the US and that most protocols call for first few months of dosing to be done in a doctor office, followed by maintenance doses that can be done or even prepared at home.

Is this treatment different than OIT? Is it more suitable for less-threatening allergies like seasonal allergies? or is there a cut-off in IgE levels this treatment would be indicated for?

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#85

Post by lifeformed »

ahstilde wrote: post #66
deskamess wrote: post #63

Are you able to service customers in Canada?

We only serve the United States right now. If you search around Canada for a "sublingual immunotherapy allergist" you might find a physician doing this in Canada.

What about Americans traveling overseas? Is shipping the issue? is there a way to pre-ship a larger supply in anticipation of a longer trip?

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#86

Post by ahstilde »

flaviuspopan wrote: post #81
ahstilde wrote: post #79

Earlier quoted context omitted.

Hi bud! Can't wait to see you in person after everything returns to normal. If I can help with your brother, let me know.

Much appreciated! I'll talk to my mom about it and see if she'd be down to try it for him. He's been exceptionally reactive to vaccines and allergens so there may be some hesitation. If you have any info about this therapy being used by people with autism, mental disabilities, etc. hook me up.

Going to take this off of HN and text you

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#87

Post by hnsfu »

reidjs wrote: post #27

I have a dust mite allergy and have tried doing this in the past, but had to stop because I moved away from my allergist. I would be interested in this type of service, but $99/month is a bit expensive for me. I have health insurance, is there any way I could get them to pay for it for me? I have had surgery for nasal polyps related to this twice if that might help my case.

Have you considered trying those ultrasonic dust mite repellents? They work for me and really made a huge difference.

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#88

Post by ahstilde »

billh wrote: post #83
ahstilde wrote: post #70

Earlier quoted context omitted.

Thank you! Patients see improvement in symptoms after 6 months, with some patients reporting improvement as soon as 6 weeks. For most patients, this means they can stop taking their antihistamines. You mentioned inhalers. While there has been connection between allergy immunotherapy and asthma, allergy immunotherapy is not a replacement for your asthma inhaler. If a patient stays on drops for 5 years, they can expect…

Do you have a patient transition plan in place in the unfortunate case of Wyndly dissolving or a contingency for continual treatment for the duration of the 5 years? It seems that it would be rather difficult for a patient to transition to another providers care on their own given how few doctors are working with SLIT.

We partner with physicians and pharmacies to provide SLIT. If anything was to happen to Wyndly, we'd transition patients directly to these physicians and pharmacies and make sure the patient experience was as seamless as possible.

It's incredibly important to us that our patient experience is as easy and seamless as possible. We'd bring this same philosophy to any transition.

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#89

Post by dlevine »

whymauri wrote: post #41
ahstilde wrote: post #9

Earlier quoted context omitted.

Thank you for the feedback! On total cost: We charge $99/mo. It's hard to give a total cost without knowing more about each person's specific allergy triggers and how well immunotherapy takes for them. Generally, we expect patients to be with us for up 5 years. On how long treatment lasts: I spoke to this in the total cost section, but it's hard to make a blanket statement. On our at-home allergy test: We use a CLIA-…

How effective is this against eczema? Without proper insurance, this is a better deal than medications like Dupixent, right?

I recently started allergy shots, and am also on Dupixent.

I asked my allergist about this when I started shots. He said that it might help with the Eczema, but nothing is guaranteed. There is at least anecdotal evidence indicating that allergy shots might be helpful for Eczema. https://acaai.org/news/your-severe-eczema-may-best-be-treate...

If you don't have insurance, Dupixent is like $2000 per month. Not sure whether their copay assist program will defray some of the cost. However, Dupixent has been life-changing for me. I went from having itchy flaky skin all over my body to being essentially normal.

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#90

Post by seehafer »

As someone who did 5 years of immunotherapy, which changed my life, I can vouch for this being a brilliant idea.

My allergist told me after completing the full course of treatment that <10% of patients do so because of the diligence required to do weekly shots week in week out.

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