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Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

news.ycombinator.com

11–20 of 144 posts

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#12

I really want this. Any plans to address shellfish allergies?

Right now, Wyndly only treats environmental allergies like pollen, pet dander, and dust. We do not treat food allergies because oral immunotherapy for food allergies is still being researched.

Stanford has a shellfish clinical trial going on right now. See https://med.stanford.edu/allergyandasthma/clinical-trials.ht...

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#14
post #7

One gap in the website that may be deliberate: I don't see any "how long will I be using the drops?" information. You posted it here, but not on the site (or if it's there, it's not obvious). While I've suffered from allergies my entire life, I don't think I care enough to spend several thousand to probably cure it. However, it's certainly interesting. Thanks for the information.

Every patient is different, so we've not made a blanket statement on our website saying "you're with us for 3 years!"

You're right that it needs to be addressed.

If you have an HSA or FSA, you can put it towards treatment with us. Many of our patients have employer-funded HSAs that they put towards their treatment with us.

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#15
I would recommend toning back some of the emotional language in your treatment comparison table -- things like "confusing terminology", "Busy staff with no time to help", and "Unhelpful Google searches". Your value prop of convenience of no shots is super obvious to me but the biased comparison table is a turn-off. It would give me a lot more confidence if the language in the table were more scientific and clinical. Specifically, I want to be able to look at the table and know for what type of person In-office shots would be better than At-home drops instead of being distracted by the language.

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#17
OK a few points from someone who uses oral drops for (strong, class 6) dust mite allergy.

* the first dose MUST be administered by a doctor (so that they can take measures if an acute adverse reaction happens) - for the same reason you must not leave the doctor for some half an hour after the first dose

* you must stick to the regime if it's going to be efficient (i.e. no forgetting your dose)

* for dust mite allergy, it takes 3 years, lasts for 3 years, and then you need to reepat it

* in general, its efficiency is measured by the amount of medication you need daily - it should diminish with time

* it's not effective in all cases

* you can measure its efficiency also by a specialized blood test

* in Europe, the drops cost ca €70 for two months

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#18
post #15

I would recommend toning back some of the emotional language in your treatment comparison table -- things like "confusing terminology", "Busy staff with no time to help", and "Unhelpful Google searches". Your value prop of convenience of no shots is super obvious to me but the biased comparison table is a turn-off. It would give me a lot more confidence if the language in the table were more scientific and clinical.…

Good marketing is emotional. Thr target audience probably has very little overlap with the HN audience.

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#19

Congrats on your launch! This sounds really promising! How do you deal with the risk of severe reactions? Is that risk diminished with drops instead of shots? I'm undergoing shot therapy now and had a life threatening anaphylactic reaction to a shot just a couple months ago. I'm concerned if I had been by myself at home I may have died? I was at the doctors office but they still called 911 for "backup" because I got…

Based on this video [1] linked in the OP, it seems like one of the big benefits is that anaphylaxis is not a side-effect of the drops.

[1] https://www.youtube.com/watch?v=TpP41WQ6pBc

Re: Launch HN: Wyndly (YC W21) – Allergy relief through at-home oral drops

#20

Congrats on your launch! This sounds really promising! How do you deal with the risk of severe reactions? Is that risk diminished with drops instead of shots? I'm undergoing shot therapy now and had a life threatening anaphylactic reaction to a shot just a couple months ago. I'm concerned if I had been by myself at home I may have died? I was at the doctors office but they still called 911 for "backup" because I got…

I'm sorry you had to go through that experience. I've fainted in a doctor's office and woken up in an ambulance. It was a very unpleasant experience.

The risk of severe reaction is much less with allergy drops compared to allergy shots [1]. Allergy drops expose the patient to less allergen and in a less invasive way at any given time compared to allergy shots. Allergy drops are much less concentrated (because they're used daily), and they deliver the allergens to the body through a mucosal membrane. Allergy shots are more concentrated (as they're used weekly or even monthly), and the body reacts to an injection much more aggressively than something taken orally.

Still, we offer every patient an EPI pen to give them peace of mind. Patient comfort is of utmost importance.

[1] https://www.youtube.com/watch?v=TpP41WQ6pBc

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