* Use seatguru to pick a good seat. Some seats look great but are very cramped or have no window at all.
* Eat way less than they serve you, I find dramatically less jetlag with having less food.
* Drink carefully, alcohol can really effect you at altitude/travel and disrupt sleep.
* I adjust my seat angle progressively over the flight. I find different parts of my back are stressed by different angles.
* Wear layers that let you adjust to very different temperatures. On the same route, KLM is going to keep the plane a very different temperature from Kenya Airways.
* Consider: Wearing a comfortable version of business casual. If you look like you travel more, you are generally treated better.
* Consider: Using a credit card with good travel insurance.
* Consider: Buying/finding lounge access if you have a > 2 hour layover at an airport.
* Consider: Taking a Benadryl/other gentle sleep medicine
* Consider: Talking to a Dr. about getting anti anxiety medicine for flight if you're a nervous flyer.
* Consider: Dash or another similar tool for offline docs if you need to do work on the plane.
* I'd enroll in AirHelp to automate getting cash back from delayed flights.
* Consider: An iPad is much easier to use because of the form factor than laptops in economy seats, it might be worth it.
* Decide early if you're going carry on only or will carry a checked bag. If you have a checked bag, try and make your carry on bag as light as possible.
* If you have sleep problems, very low doses of melatonin are helpful for resetting sleep patterns. If you have a prescription and local laws allow, Ritalin/Adderall help some people.
* Get a good power adapter for wherever you're traveling with no moving parts.
* If you're going somewhere with electronics availability challenges, bring a second adapter.
* Anker makes incredible battery packs that will reduce your stress. If you're trying to take an Uber without a phone, that's hard.
* Consider: Try to wear comfortable yet professional/nicer shoes. Loafers are a good choice.