Ketogenic diets inhibit mitochondrial genesis, induce cardiac fibrosis in rats
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Re: Ketogenic diets inhibit mitochondrial genesis, induce cardiac fibrosis in rats
#2Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis in rats
Re: Ketogenic diets inhibit mitochondrial genesis, induce cardiac fibrosis in rats
#3This paper was surprisingly easy to read and understand.
Re: Ketogenic diets inhibit mitochondrial genesis, induce cardiac fibrosis in rats
#4Is cardiac fibrosis good or bad? I skimmed through the article but couldn’t immediately tell.
Re: Ketogenic diets inhibit mitochondrial genesis, induce cardiac fibrosis in rats
#5Is cardiac fibrosis good or bad? I skimmed through the article but couldn’t immediately tell.
Fibrosis = Scarring. Not good for the heart.
Re: Ketogenic diets inhibit mitochondrial genesis, induce cardiac fibrosis in rats
#6This is concerning, because whilst not strictly ketogenic, my (and my partners) diet has shifted to significantly less carbs, as part of managed weightloss and if the consequence is cardiac fibrosis, thats a significant concern for her: she has pre-existing conditions including lack of strong heart function.
Re: Ketogenic diets inhibit mitochondrial genesis, induce cardiac fibrosis in rats
#7Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis in rats
I get so annoyed by authors that bury this point. Rodents are NOT tiny humans. Although there are some findings that carry over, there is much that does not.
Re: Ketogenic diets inhibit mitochondrial genesis, induce cardiac fibrosis in rats
#8Is cardiac fibrosis good or bad? I skimmed through the article but couldn’t immediately tell.
Fibrosis = Scarring. Not good for the heart.
Thanks! Would love a TLDR from you or another knowledgeable HNer. I couldn’t tell how big a problem this would be for people who are on the keto or IF spectrums.
Re: Ketogenic diets inhibit mitochondrial genesis, induce cardiac fibrosis in rats
#9It's important to remember that the whole point of the keto diet is to introduce a near-fundamental change in your body's metabolism, including brain function.
It should be regarded the same way you would regard a very potent medication-- one that does not have FDA approval. It's probably the sort of thing you should approach with extreme caution and the advice of a doctor & dietician.
Re: Ketogenic diets inhibit mitochondrial genesis, induce cardiac fibrosis in rats
#10The title of this paper is so deliberately misleading that I flagged the submission.
There is no reason whatsoever to think that the human response to ketosis would be at all similar to that of rats. And rats are what they studied.
As long as rags like Nature keep publishing this garbage, hacks will keep producing it. Sad state of affairs all around.