Live data from Hacker News

Israeli study finds 94% drop in symptomatic Covid-19 cases with Pfizer vaccine

reuters.com

241–250 of 460 posts

Re: Israeli study finds 94% drop in symptomatic Covid-19 cases with Pfizer vaccine

#241

Earlier quoted context omitted.

Are they? Didn't the EU put up a vaccine export ban? https://www.bbc.com/news/world-europe-55860540

A Dutch facility is producing vaccines ( AZ ) for the UK, as they have been financed from the UK deal.

That factory is in Belgium right? Or do we have one too? (I don't really follow much covid news)

Re: Israeli study finds 94% drop in symptomatic Covid-19 cases with Pfizer vaccine

#242
post #85

Earlier quoted context omitted.

Short answer: apparently, yes. The process is too unique and new to just be replicated in other factories. Derek Lowe has an in-depth and readable explanation: https://blogs.sciencemag.org/pipeline/archives/2021/02/02/my...

He identified the microfluidic liquid nanoparticle assembly machines as the bottleneck but didn't specify why their manufacture can't be spread up. We should be purchasing the IP for hundreds of billions of dollars and open sourcing the technology, not leaving it up to the companies to slowly set up their facilities and build manufacturing partnerships.

It wouldn't even required to purchase or transfer the IP at all, the governments should just fund the setup of the necessary production capabilities and lease them to BioNTech/Pfizer and Moderna at basically zero costs.

Vaccine production is still far to low to vaccinated the whole world population any time soon and only then we can prevent the creation of new mutant strains.

Re: Israeli study finds 94% drop in symptomatic Covid-19 cases with Pfizer vaccine

#243
post #199

Earlier quoted context omitted.

Remember that hospitalizations take at least 2-3 weeks post infection to occur, and that you don’t see protection from the first dose for at least five days or so. So you’d expect hospitalizations to lag 18-26 days or so. Also the chart is not saying all those groups had vaccines: those under 60 largely haven’t been. The labels could have been clearer. It’s just a chart of change in hospitalization by age from a star…

You are saying "Late vaccinated 0-59 years old" should be read as "Unvaccinated and late vaccinated 0-59 years old"? Why didn't they use that label then?

Actually, I was wrong. I checked the source paper. I believe the labels refer to cohorts from cities that were early in the vaccination campaign vs cohorts from cities that were late in the campaign.

So 0-59 late vaccinated means some vaccines but later in time and fewer in number.

This is what I gathered from the abstract anyway: https://www.medrxiv.org/content/10.1101/2021.02.08.21251325v...

Apologies for original error.

Re: Israeli study finds 94% drop in symptomatic Covid-19 cases with Pfizer vaccine

#244
post #234

Earlier quoted context omitted.

Because they have been vaccinated. The vaccine just (likely) hasn't taken affect and started affecting the statistics yet.

I'm not sure that is true. As I understand it, it's a cohort of people of that age who live in a geographical area of Israel where vaccination was started early. So it includes people of that age who declined the vaccine/didn't get it fr other reasons. Of course, you're also correct that another important factor is that some of the cohort are not yet fully protected. The definitions are here: https://www.medrxiv.org/…

Yeah I was wrong. I believe early and late refers to cities and the cohorts are taken from early or late cities.

Re: Israeli study finds 94% drop in symptomatic Covid-19 cases with Pfizer vaccine

#245
post #230

Earlier quoted context omitted.

Vaccinated with a second dose means full immunity 1 week after, possible death 3 to 7 weeks after (1 + (1 to 2) + (2 to 4)). So a decline should start to be visible since last week maybe. But I wouldn't get nervous for another 2 to 3 weeks in case it doesn't fall sharply, data is always noisy and everything is spread out the more dependencies on previous events and times there are.

We don't need full immunity to see the effect tho.

Right. But still, don't worry yet, worry when it hasn't shown improvement in a few weeks.

Edit: Also, when you look at the JHU data (e.g. via google), it shows a peak at Jan 15th in the number of cases followed by a steady decline. The number of deaths peaks on Jan 28th, followed by a similar, steady decline. Which is as expected, so I would say we are already seeing the effects on the number of deaths.

Sorry that I didn't look at the data earlier before replying.

Re: Israeli study finds 94% drop in symptomatic Covid-19 cases with Pfizer vaccine

#246
The side effect of this amazing BioNTech/Pfizer success: Meanwhile AstraZeneca is clearly only the second choice. At least locally here in my town (EU) people line up for Biontech, but the vaccination centers that offer AstraZeneca report up to 50% no shows.

Re: Israeli study finds 94% drop in symptomatic Covid-19 cases with Pfizer vaccine

#247
Congratulations, but some sceptical notes.

The spring is coming, ending the wave like last year. This can reduce the cases by a similar amount. We will have to wait till next season what will happen. The sun and season has a dramatic influence on Covid. We saw that last year. Related with vitamin-D and ultra-violet radiation.

Recently some countries had changes in PCR tests. Austria had a similar reduction after not using the PCR tests. They had 95% false positives on PCR, compared to other tests. The PCR is problematic due to the usage of far too many cycles. When testing random persons, it gives 95% false positives over 35 cycles, but many countries even use 45 cycles or more. Sadly, using too many cycles is not scientific evidence for anything.

Many countries also reached a natural herd immunity. Sweden is now very close to getting 60% anti-body herd immunity. Besides that we have T-cell herd-immunity of which we do not know that much. I already had covid, got my anti-bodies & T-cell-immunity and am now fully immune.

Probably not applicable to Israel. Certain countries use cheap old-school medicine that prevent the disease. Like India and Ghana. Changes in medicine-use give similar changes in cases. If you don't believe it, just talk to some people that live there. They do not have a covid problem. IMHO this is the best but least profitable way to deal with the disease.

Controversial: The vaccines can give strong fevers. This is a well known side-effect. These might have thinned out the weakest people. Which now did not catch covid. While I think the effect is small, it can give a temporary reduction of the cases. I hope the medicine companies will improve the vaccines, so we do not get these side-effects.

The difference between these can be subtle and depends on raw data. But statistical analysis can already show some details.

Re: Israeli study finds 94% drop in symptomatic Covid-19 cases with Pfizer vaccine

#248

Earlier quoted context omitted.

doesn't explain why European ones are happening in one factory

> in one factory This is not true; Not sure if i can find the source i read (at spiegel.de) but i will have a look and post it if i find it.)

So apparently the main EU plant for production of the vaccine is in Puurs, Belgium.

The second one (already producing today) is in Marburg, Germany. Source in German: > "In the first half of 2021, 250 million doses of the vaccine are to be produced..."

https://www.spiegel.de/wirtschaft/unternehmen/corona-impfsto...

I don't know if there are more factories...?

Re: Israeli study finds 94% drop in symptomatic Covid-19 cases with Pfizer vaccine

#249
post #8

Earlier quoted context omitted.

You perfectly expressed my feelings. Greetings from Germany!

From Germany here as well, I am extremely sad how the vaccine situation was handled, 3.3 percent of population over two months is an extremely bad metric, especially when the lockdown situation is being lengthened for another month. By this rate, people won't be vaccinated by 2021. The dashboard for Germany: https://impfdashboard.de/

It's important to not get too discouraged with "By this rate..." The rate is increasing and should continue to do so. More production capacity is coming online week by week.

Re: Israeli study finds 94% drop in symptomatic Covid-19 cases with Pfizer vaccine

#250
Being an Israeli I wouldn't trust anything coming from Israel related to COVID-19.

Current government is practically crime syndicate, all the decisions related to COVID-19 are made secret for at least 30 years, agreement with Pfizer is mostly secret, case number is manipulated by gauging tests conducted and selecting appropriate population groups and vaccines are forced on population under pain of limiting access to work, grocery and flights abroad.

Post reply on HN