I remember a study suggesting the Chickenpox vaccine suppresses outbreaks of HSV1 and HSV2 https://www.dovepress.com/efficacy-of-the-anti-vzv-anti-hsv3...
Well, that makes a lot of sense, because the chicken pox virus is in the herpesvirus family.
Mouse studies show gene therapy can cause big drop in latent herpes infections
21–30 of 77 posts
Re: Mouse studies show gene therapy can cause big drop in latent herpes infections
#22.. In mice. It is unknown if it will work in humans. In addition, what are the long term consequences of causing multiple DNA cuts in nerve cells that the DNA repair mechanism cannot repair? There is still a very long, long way to go.
I am baffled why you are being downvoted. While this research is very promising, it's also not hard for me to imagine a scenario where these targeted molecular "DNA scissors" do something unexpected. And while the risks of gene editing seems worth it for fatal or debilitating diseases, I don't think I'd want to be on a trial for this for a disease that is primarily an annoyance. Again, I think the research and techni…
> I don't think I'd want to be on a trial for this for a disease that is primarily an annoyance.
You can go blind, lose your sense of smell permanently, and get encephalitis from bad herpes outbreaks. It isn't just an inconvenience to those people.
And because herpes infects practically the entirety of the population, these problems are more common than you would expect.
And that's before we start chewing through all the viral data were going to get due to everybody actually paying attention to symptoms due to Covid. I suspect that the "viral hypothesis" people are going to have a field day for the next 10 years.
Re: Mouse studies show gene therapy can cause big drop in latent herpes infections
#23Earlier quoted context omitted.
I am baffled why you are being downvoted. While this research is very promising, it's also not hard for me to imagine a scenario where these targeted molecular "DNA scissors" do something unexpected. And while the risks of gene editing seems worth it for fatal or debilitating diseases, I don't think I'd want to be on a trial for this for a disease that is primarily an annoyance. Again, I think the research and techni…
> I don't think I'd want to be on a trial for this for a disease that is primarily an annoyance. You can go blind, lose your sense of smell permanently, and get encephalitis from bad herpes outbreaks. It isn't just an inconvenience to those people. And because herpes infects practically the entirety of the population, these problems are more common than you would expect. And that's before we start chewing through all…
Thanks for your response, I wasn't really aware of the prevalence of herpes-related blindness and encephalitis.
Re: Mouse studies show gene therapy can cause big drop in latent herpes infections
#24One could imagine this technique also working in latent reserves of coronavirus harbored by people who have become infected.
Re: Mouse studies show gene therapy can cause big drop in latent herpes infections
#25Can we get mRNA vaccine to Herpes
Re: Mouse studies show gene therapy can cause big drop in latent herpes infections
#26One could imagine this technique also working in latent reserves of coronavirus harbored by people who have become infected.
I'd really like to see what happens when we eliminate HERVs (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187282/#:~:tex....) from our genome.
Re: Mouse studies show gene therapy can cause big drop in latent herpes infections
#27Earlier quoted context omitted.
Ok, well maybe this thread can be a tiny part of the solution to that stigma. First off herpes comes in two primary variants: HSV-1 and HSV-2. Most humans on Earth (between 60% and 95%) have HSV-1, and it's estimated that around 16% of humans have HSV-2. Herpes is extremely common. If you want references or more info, see the wikipedia page [0]. According to the article, the researchers are currently focused on HSV-1…
Supposedly they've stopped testing for herpes most of the time because of how likely it is someone has it, how unactionable the information is, and the stress it causes.
Anecdote: Doctors are certainly hesitant. I had to insist my doctor test me when I found out my then partner cheated on me.
At first glance, they're certainly reluctant to do so.
Re: Mouse studies show gene therapy can cause big drop in latent herpes infections
#28I remember a study suggesting the Chickenpox vaccine suppresses outbreaks of HSV1 and HSV2 https://www.dovepress.com/efficacy-of-the-anti-vzv-anti-hsv3...
I wonder if that's why I've never had HSV1 despite my wife having had several outbreaks while we've been together. We aren't careful during outbreaks because I figure I'm going to get it sooner or later and we can't go weeks without kissing, but I've still never had an outbreak.
Re: Mouse studies show gene therapy can cause big drop in latent herpes infections
#29One could imagine this technique also working in latent reserves of coronavirus harbored by people who have become infected.
I don't think coronavirus hides itself in the same way? The long-lived herpes DNA folds itself up compactly inside the nerve cells, which is very unique capability specific to that type of virus. Attacking these dormant genes requires some specific molecular machinery to either keep these genes in their dormant state (current antiviral therapies), or to open and snip them up (TFA).
I'm pretty sure coronavirus reservoirs are just regular virus sitting around in parts of the body the immune system doesn't reach. Different problem.
Re: Mouse studies show gene therapy can cause big drop in latent herpes infections
#30.. In mice. It is unknown if it will work in humans. In addition, what are the long term consequences of causing multiple DNA cuts in nerve cells that the DNA repair mechanism cannot repair? There is still a very long, long way to go.
in mice.. your comment is so helpful man. in mice is surprisingly useful and comments like yours make anything studied "in mice" out to be useless. please, get out of threads on the cutting edge of medical information, you aren't useful with your unwarranted cynicism and skepticism. please. LEAVE.