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Making Vaccine

lesswrong.com

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Re: Making Vaccine

#11

Post by sct202 »

raylad wrote: post #10
fredgrott wrote: post #8

Earlier quoted context omitted.

it's not you are implying.. they use peptide..real vaccines use mRNA thus more effective than this one at say about 10% effectiveness.. Sorry for being brief as it would take a more in depth hour explanation of why the difference in effectiveness.. CDC had a recent article on the differences between this approach and the approach they and pharms chose namely mRNA

>real vaccines use mRNA thus more effective than this one at say about 10% effectiveness.. Not true. Novavax is just peptides and is 96% effective against the original Wuhan covid-19 strain.

Novavax is growing whole modified spike proteins and sticking a dozen of them on to a nanoparticle. The article mentions their peptide is only a small fraction of the size of the spike protein.

Re: Making Vaccine

#12

Post by hannob »

aqme28 wrote: post #3

I'm amazed at the price here. $1k for 500 doses, and the author stated in the comments that they could have saved a lot more per dose if they bought in bulk. It seems like a failure of the system that no one is trying for FDA approval or industrialization.

The prices for Astrazeneca vaccines are within the same range.

There are also efforts for some simple to produce vaccines underway, it's just not the ones you'll likely see used widely in industrialized countries. An example is the chinese Coronavac vaccine.

Though keep in mind making vaccines isn't just producing them, it's also running trials. It pretty much doesn't matter how cheap your production is, it will hardly affect the cost of the trial. And after all they're there so you actually know whether your vaccine works - and that part certainly shouldn't be skipped.

Re: Making Vaccine

#13

Post by lxe »

Just to summarize for my own understanding/fascination: this person DIY's 500 doses of nasal-spray COVID-19 vaccine for $1000 using ingredients and tools off of Amazon and easy-to-source synthesized peptides with minimal skill?

Re: Making Vaccine

#14

Post by habryka »

lxe wrote: post #13

Just to summarize for my own understanding/fascination: this person DIY's 500 doses of nasal-spray COVID-19 vaccine for $1000 using ingredients and tools off of Amazon and easy-to-source synthesized peptides with minimal skill?

Yes, though the vaccine is likely to have substantially less efficacy than current mRNA based vaccines from Pfizer and Moderna, though I think it's promising enough that some level of efficacy (like idk. maybe 50%, who knows) doesn't seem out of the question (whereas Moderna and Pfizer are likely 90%+).

Re: Making Vaccine

#15

Post by fabian2k »

If there is one thing I certainly wouldn't just play around with it's the immune system. It's incredibly dangerous and easily capable of causing all kinds of harm to yourself up to killing you outright.

A vaccine is designed to produce an immune response of the right magnitude. Too low and it doesn't work, too high and it'll cause damage. At least one of the vaccine candidates in development was put back to the drawing board because the immune response wasn't strong enough. So this is not an area that is entirely predictable, you have to carefully test this to know if it works.

I'd also be very careful about the inhalation route. Inhalable insulin is a well-known failure, in part because of side effects due to the inhalation. And that is a protein that isn't designed to activate your immune system.

I also hope the synthesized peptides were carefully purified, you really don't want to inhale e.g. residual trifluoracetic acid.

Re: Making Vaccine

#16

Post by deadlyvaccine »

I really hope no vaccine will work and all over-80 people will pay for all the suffering they have done for 98% of the population. People are living in conditions similar to jail second year in a row!

Re: Making Vaccine

#17

Post by [deleted] »

deadlyvaccine wrote: post #16

I really hope no vaccine will work and all over-80 people will pay for all the suffering they have done for 98% of the population. People are living in conditions similar to jail second year in a row!

[deleted]

Re: Making Vaccine

#18

Post by [deleted] »

fabian2k wrote: post #15

If there is one thing I certainly wouldn't just play around with it's the immune system. It's incredibly dangerous and easily capable of causing all kinds of harm to yourself up to killing you outright. A vaccine is designed to produce an immune response of the right magnitude. Too low and it doesn't work, too high and it'll cause damage. At least one of the vaccine candidates in development was put back to the drawi…

[deleted]

Re: Making Vaccine

#19

Post by maxerickson »

lxe wrote: post #13

Just to summarize for my own understanding/fascination: this person DIY's 500 doses of nasal-spray COVID-19 vaccine for $1000 using ingredients and tools off of Amazon and easy-to-source synthesized peptides with minimal skill?

They exposed their nasal tissues to peptides from the virus.

You could call it an inoculation. I think it is okay to reserve 'vaccine' for something a bit more fine tuned and tested.

Re: Making Vaccine

#20

Post by koeng »

timerol wrote: post #2

Similar to the author of the post, I'm surprised that I haven't seen or heard much about bio-hacking your own vaccine. Seems like an interesting trend to follow, though I will be waiting for an FDA-approved vaccine myself. I am a little worried that https://radvac.org/vaccine/ mentions that their vaccine has "the most extreme complication in some recipients of stuffy noses." I would expect a functioning vaccine to el…

Josiah Zayner did one that looked fairly promising (believe it was either an mRNA or DNA vaccine), but unfortunately he got banned from a lot of media (like youtube) for it, so that may partially explain why you haven't seen or heard much.
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