Making Vaccine
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Making Vaccine
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Re: Making Vaccine
#2Similar to the author of the post, I'm surprised that I haven't seen or heard much about bio-hacking your own vaccine. Seems like an interesting trend to follow, though I will be waiting for an FDA-approved vaccine myself.
I am a little worried that https://radvac.org/vaccine/ mentions that their vaccine has "the most extreme complication in some recipients of stuffy noses." I would expect a functioning vaccine to elicit an immune response. I would be more comforted if, like the mRNA vaccine, a sizeable percentage of people trying the DIY vaccine developed a short fever. Though according to them this is expected: "Intranasal delivery of chitosan-based vaccines have shown mild side effects and high levels of efficacy of both mucosal and systemic immunity, when delivered in a prime-boost regimen (in both animal models and human trials). "
Re: Making Vaccine
#3I'm amazed at the price here. $1k for 500 doses, and the author stated in the comments that they could have saved a lot more per dose if they bought in bulk.
It seems like a failure of the system that no one is trying for FDA approval or industrialization.
Re: Making Vaccine
#4> In principle one can run a similar antibody test on a mucus sample, but
I'd really like to know what those reasons are. It seems like a pretty important detail.
Re: Making Vaccine
#5I'm amazed at the price here. $1k for 500 doses, and the author stated in the comments that they could have saved a lot more per dose if they bought in bulk. It seems like a failure of the system that no one is trying for FDA approval or industrialization.
> FDA approval
Of what?
Edit: I get it now, sorry. I think FDA approval would bump up the price quite a bit.
Re: Making Vaccine
#6Similar to the author of the post, I'm surprised that I haven't seen or heard much about bio-hacking your own vaccine. Seems like an interesting trend to follow, though I will be waiting for an FDA-approved vaccine myself. I am a little worried that https://radvac.org/vaccine/ mentions that their vaccine has "the most extreme complication in some recipients of stuffy noses." I would expect a functioning vaccine to el…
Because complying with GMP is tedious and expensive. One mistake and you could end up with blood poisoning or a brain-eating microbe. Lab grade material is not the same as pharmaceutical grade material. You can get a lot of expensive anti-cancer drugs too at bulk prices from lab suppliers. That does not mean they are rated for human consumption. What's good for the lab rat is not necessarily good for the homo sapien.
https://en.m.wikipedia.org/wiki/Good_manufacturing_practice
Granted, more biohacking and bio experimentation is a good thing. Innovation should not be gatekept by institutions and the establishment.
Here's a startup idea for whoever's interested:
Take lab grade pharmaceutical drugs and turn them into human-rate drugs at a low cost.
Re: Making Vaccine
#7I'm amazed at the price here. $1k for 500 doses, and the author stated in the comments that they could have saved a lot more per dose if they bought in bulk. It seems like a failure of the system that no one is trying for FDA approval or industrialization.
This Lesswrong thread has a good discussion about the subject.
https://www.lesswrong.com/posts/niQ3heWwF6SydhS7R/making-vac...
Re: Making Vaccine
#8I'm amazed at the price here. $1k for 500 doses, and the author stated in the comments that they could have saved a lot more per dose if they bought in bulk. It seems like a failure of the system that no one is trying for FDA approval or industrialization.
it's not you are implying.. they use peptide..real vaccines use mRNA thus more effective than this one at say about 10% effectiveness..
Sorry for being brief as it would take a more in depth hour explanation of why the difference in effectiveness..
CDC had a recent article on the differences between this approach and the approach they and pharms chose namely mRNA
Re: Making Vaccine
#9Curious whether short peptides are sufficient to generate a formidable immune response.
Looking at the paper cited, it's not trivial to detect T-cell immunity so I'm not sure a general antibody test would be able to pick up an immune response.
It's probably better than doing nothing, but it's not clear whether it's even in the same ballpark as a Pfizer vaccine.
edit: I'm not sure about t-cell vs b-cell responses in immunoassays, can anyone with experience point out what is going on with these peptides?
Re: Making Vaccine
#10I'm amazed at the price here. $1k for 500 doses, and the author stated in the comments that they could have saved a lot more per dose if they bought in bulk. It seems like a failure of the system that no one is trying for FDA approval or industrialization.
it's not you are implying.. they use peptide..real vaccines use mRNA thus more effective than this one at say about 10% effectiveness.. Sorry for being brief as it would take a more in depth hour explanation of why the difference in effectiveness.. CDC had a recent article on the differences between this approach and the approach they and pharms chose namely mRNA
>real vaccines use mRNA thus more effective than this one at say about 10% effectiveness..
Not true. Novavax is just peptides and is 96% effective against the original Wuhan covid-19 strain.