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FDA approves first monthly injectable to treat HIV infection

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Re: FDA approves first monthly injectable to treat HIV infection

#151
post #41

Earlier quoted context omitted.

Have we considered telling people to "just stay home" and to "not have sex"? Maybe that's the trick.

Right. Abstinence doesn't really work in the real world, only in the spherical-cow world where humans are perfectly obedient.

Isn't that a tacit argument against stay-at-home orders?

Re: FDA approves first monthly injectable to treat HIV infection

#152
post #73

> The cost, however, is steep — the list, or wholesale, price is $3,960 a month, or more than $47,500 a year. The list price for the one-time initiation dose is $5,490. Median income in the US is ~$31K apparently. So even in a rich country, this is like 50% more than the income of a typical person. My understanding is the funding for the trials was partly from NIAID. This seems like yet another case where public fund…

Does anyone actually end up paying the 47,500 a year for the drug or is this some sort of gimmick on the part of the drug company when they negotiate reimbursement rates with CMS or other payers?

The standard brand name combination pills come to nearly $20,000 a year for the public insurers in Canada. They really do pay that much.

Re: FDA approves first monthly injectable to treat HIV infection

#153

Earlier quoted context omitted.

> where corporations and their boards are legally bound to maximize profit, ignoring morals for profit. Where is this true? It’s not even a definable legal standard.

You are definitely correct and thanks for pointing it out. Generalizations and miss-information doesn't help at all. I obviously need to go out for a walk before I comment on these type of news. It's super exciting but also extremely depressing since the ones who'd need this the most likely wont afford it.

The FDA approves ~40 drugs a year. If you want 40 new drugs a year, it unfortunately will cost somebody something to coordinate the large number of professionals over many years required by a modern development effort. Few drugs have been developed successfully on good intentions.

I find excitement in the fact that we have found a way to get new treatments and cures. Other systems have been tried that weren’t so successful at pumping out new tech.

Re: FDA approves first monthly injectable to treat HIV infection

#154

Earlier quoted context omitted.

3k month sounds about right for a chronic condition. Many many people pay at least this to stay alive. That said , Universal Health Care is needed for stuff like this to work. At 3k a month it makes the most sense to try and emigrate to a better country.

That doesn't scale. If you push the cost of healthcare to other countries when it becomes too expensive instead of fixing the system in the country where you live then every other country with a better system's healthcare will collapse as well. Vote to improve the system where you live and make sure that your representatives realize that it could be them or their relatives in your situation. Quite a few countries hav…

You could also buy a 10$ bus ticket

https://khn.org/news/americans-cross-border-into-mexico-to-b...

Re: FDA approves first monthly injectable to treat HIV infection

#155
post #87

Earlier quoted context omitted.

. [just gonna stop commenting on this site]

> Is the flamewar tangent part of this the comment on capitalism or "Capitalized medicine"? Doesn't really seem flamie to me but obviously others disagree. The problem is the generic ideological tangent. You can perhaps (maybe!) imagine a substantive article and thread on the economics of cures vs. treatments. But that would require different initial conditions—primarily an interesting, informative article that broug…

More time has been spent discussing the nature of flamewars.

A little ironic perhaps ..

Re: FDA approves first monthly injectable to treat HIV infection

#156
post #71

Earlier quoted context omitted.

It's a shame that PrEP is still so expensive.

It is expensive, but it is accessible. Truvada for PrEP has a program both for insured patients that covers co-pays up to $7,200 per year (I pay zero dollars a year because of this), and a medication assistance program for uninsured patients where after signing up and meeting eligibility requirements (which are basically 'are you at risk of getting HIV' and 'are you not wealthy to the point where you should definitel…

Just confirming this.

I don’t know anyone paying full price for Truvada. It’s either free, or whatever your insurance copay for drugs happens to be. (It’s annoying I have to go to a specific pharmacy with my drug plan, but whatever.)

Re: FDA approves first monthly injectable to treat HIV infection

#157

Earlier quoted context omitted.

That doesn't scale. If you push the cost of healthcare to other countries when it becomes too expensive instead of fixing the system in the country where you live then every other country with a better system's healthcare will collapse as well. Vote to improve the system where you live and make sure that your representatives realize that it could be them or their relatives in your situation. Quite a few countries hav…

You could also buy a 10$ bus ticket https://khn.org/news/americans-cross-border-into-mexico-to-b...

Before long they'll be smuggling insulin rather than cocaine if it isn't already happening.

Re: FDA approves first monthly injectable to treat HIV infection

#158
post #30

Earlier quoted context omitted.

> we at least must allow them to profit as much or more from a cure as they would from a treatment I think that’s where you go wrong. There are huge profit incentives for a cure. If a biotech company comes up with a cure they will instantly have the business of every afflicted person on the planet. The market for that and price they can charge will be way larger than a slightly different treatment. Beyond that, there…

There are indeed huge profit incentives for a cure. There are even larger profits to be had from a monthly treatment that the patient has to take for the rest of their lives. Are you saying people that aren’t taking a monthly biologic injection for example will start coming out of the woodwork for a cure when normally they wouldn’t seek treatment for their malady?

You speak as if there is just one entity making these things. There isn’t, there are hundreds of labs all over the world working on this. If one of them comes out with a treatment alternative like this it may gain some traction but if they came out with a cure they would dominate the global market

Re: FDA approves first monthly injectable to treat HIV infection

#159
post #41

Earlier quoted context omitted.

Right. Abstinence doesn't really work in the real world, only in the spherical-cow world where humans are perfectly obedient.

Isn't that a tacit argument against stay-at-home orders?

Yeah, I'm persuaded by the Julia Marcus school of thought that simply ordering people to stay home is important but not nearly enough. You have to provide ways for people to reduce their risk in case they decide not to listen to your orders.

I personally stay home as much as I can, but I have certain privileges many others don't.

Re: FDA approves first monthly injectable to treat HIV infection

#160
I’ve been HIV+ since I was 18 (mid-20’s now). I’ve taken the Gilead combo pills since a few months after I was diagnosed, first Stribild and now Genvoya, the difference being a new form of tenofovir.

I miss probably one dose a month, maybe two. I don’t take my pill at the same time everyday, probably in a 4 or 5 hour window vs. the 2 hour window my doctor recommends. I’ve never had any side effects and I’ve been undetectable since I began treatment.

I’m not sure I’m interested in this injectable regimen. My HIV treatment will last for the majority of my life; I don’t feel like I can risk any amount of reduced long term efficacy with a new drug. I also don’t love needles. I’m excited to talk to my doctor about it, though.

Like birth control, the more options there are, the better. HIV treatment is truly a marvel of modern medicine.

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