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SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

biorxiv.org

1–10 of 131 posts

Re: SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

#5
Pulling directly from TFA,

> Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore 501Y.V2 shows substantial or complete escape from neutralizing antibodies in COVID-19 convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and may foreshadow reduced efficacy of current spike-based vaccines.

Ugh; this hurts to read. The callouts there are "complete escape [from] convalescent plasma" (prior exposure won't help you), and "reduced efficacy of current spike-based vaccines" (which is all of the ones deployed, I believe).

Re: SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

#6

Is this just one of the hundreds of variants that have been found so far but do not spread widely, or is there some reason to believe this variant is more easily spread and will become common?

This is one of the first variants that avoids our current plan of defense: antibody plasma.

At a minimum, it means that treating COVDID19 may require further tests to see if we have COVID19, or... what probably will be called COVID20 or COVID21 (for 2020 or 2021, depending on when we want to pin the "origin date" of this virus variant). I'm assuming COVID20 in my ignorance...

If COVID19 treatment doesn't work, doctors will then have to try COVID20 treatment.

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It really depends on how much COVID20 has mutated compared to COVID19, as well as how effective Pfizer, Moderna, AstraZenica, and Johnson & Johnson's vaccines are against COVID20.

They've only been tested against COVID19 (the 2019 variant). We'll have to run tests to see if our defenses are good enough for COVID20, or if we have to start the vaccine race all over again.

Re: SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

#7

Is this just one of the hundreds of variants that have been found so far but do not spread widely, or is there some reason to believe this variant is more easily spread and will become common?

This one is spreading more widely in South Africa and has also been found in other countries already. It has an advantage in populations that have prior immunity from natural infection.

Re: SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

#8
I'm curious, is this headline (which differs significantly from the one on the paper itself) making the common mistake of conflating "immunity" with "antibodies"? Just wondering if there is a difference between showing that the new strain is resistant to the antibodies as opposed to showing that it is likely to reinfect people who recovered from a previous strain.

Re: SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

#10
Note that

1. The sera they tested this against obtained antibodies through natural infection. It's not clear whether vaccine-induced immunity is protective against this variant.

2. They only tested for neutralizing antibodies, but there is still T-Cell response which could provide protection.

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