I'd be somewhat more interested in a program like this if it were being run by someone I believed actually wanted in good faith to improve education/business, rather than having ulterior political motives. Thiel is quite open that his main motivation is that he thinks universities promote politics he dislikes, so he'd like to destroy them for that reason. He
also claims that in doing so he'd improve education, but it seems like a secondary motivation. My guess is that he would be willing to accept education even getting slightly worse as a tradeoff, if it got rid of the negative influence (in his view) of universities for libertarian politics.
(See Woz and Salman Khan for examples of education reformers who seem to have education reform as their actual #1 goal.)
edit: Of course, as full disclosure I'm in academia, so perhaps have my own ulterior motives. =] But honestly I think Salman Khan's approach is a bigger threat to the higher-education status quo than Thiel's is, mainly because it's much more scalable. So from a pure self-interest point of view I ought to dislike that one more!