Live data from Hacker News

Why cancer cells waste so much energy

news.mit.edu

111–120 of 199 posts

Re: Why cancer cells waste so much energy

#111

Earlier quoted context omitted.

Good point--I amended my original comment to specify folic acid. What you're saying about stable DNA makes sense. I'm curious, though, if the supplementation helps the body generate more NAD+ (relative to someone with a deficiency), and if that could help cancer proliferate in its earliest stages (hence why the correlation is most pronounced in people already likely to develop cancer--smokers).

That is the whole problem - everything that benefits your body, benefits cancer and vice-versa. Cancer forms all the time - body should handle it when functioning correctly (via immune system). NAD is essential for many functions, especially longevity as sirtuins require it for proper function. As far as I know only massive Vitamin C doses uniquely influence cancer in negative manner and get pretty much no effect on…

I know a few friends who take NAD booster supplements. Does it increase their chance of developing cancer? Just curious as there seems to be a connection based on what I read recently.

Re: Why cancer cells waste so much energy

#112

Earlier quoted context omitted.

Good point--I amended my original comment to specify folic acid. What you're saying about stable DNA makes sense. I'm curious, though, if the supplementation helps the body generate more NAD+ (relative to someone with a deficiency), and if that could help cancer proliferate in its earliest stages (hence why the correlation is most pronounced in people already likely to develop cancer--smokers).

That is the whole problem - everything that benefits your body, benefits cancer and vice-versa. Cancer forms all the time - body should handle it when functioning correctly (via immune system). NAD is essential for many functions, especially longevity as sirtuins require it for proper function. As far as I know only massive Vitamin C doses uniquely influence cancer in negative manner and get pretty much no effect on…

That makes total sense—thanks!

Re: Why cancer cells waste so much energy

#113
post #110

Does the difference in metabolic pathway lead to e.g. different waste products present in the blood? I.e. could you do a blood test to detect elevated levels of fermentation-based metabolism, indicating that it might be time to do a deeper cancer screen?

Lactate Dehydrogenase (LDH) is one test that uses this effect and it is used for monitoring some cancers. It's non-specific to cancer, but elevated levels can be cause by a range of not-great conditions.

https://en.wikipedia.org/wiki/Lactate_dehydrogenase#Testing_...

Re: Why cancer cells waste so much energy

#114

Worth noting that unlike the cells of the human body, cancer cells are unable to utilize ketones as an energy source[0][1], hence the benefits of a ketogenic diet. A ketogenic diet can also be ideally coupled with intermittent fasting[2] in order to engage/enhance autophagy within the body. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842847/ [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375425/ [2] https://…

Back when I had cancer in 2015, I read about this effect but I also read there was some potential danger in the cancer cells adapting to ketosis and accelerating their growth, so I thought it seemed too risky. It seems like the research may have improved since then though to suggest some benefit.

Re: Why cancer cells waste so much energy

#115

Earlier quoted context omitted.

That is the whole problem - everything that benefits your body, benefits cancer and vice-versa. Cancer forms all the time - body should handle it when functioning correctly (via immune system). NAD is essential for many functions, especially longevity as sirtuins require it for proper function. As far as I know only massive Vitamin C doses uniquely influence cancer in negative manner and get pretty much no effect on…

I know a few friends who take NAD booster supplements. Does it increase their chance of developing cancer? Just curious as there seems to be a connection based on what I read recently.

Probably, in specific context - unrecognized and left to develop cancer will be boosted according to this research and if supplement reaches it which depends on many factors.

At this point there is literrary nothing you can recommend to your friend.

Re: Why cancer cells waste so much energy

#116
post #48

Earlier quoted context omitted.

He wasn't fasting, he was on fruits diet.

He drank carrot juice which I'd say is severely limiting your caloric intake.

Also keep in mind that sugar is the enemy. Your body has chemistry to make sugar - there is no-need to ingest it.

Re: Why cancer cells waste so much energy

#117

Worth noting that unlike the cells of the human body, cancer cells are unable to utilize ketones as an energy source[0][1], hence the benefits of a ketogenic diet. A ketogenic diet can also be ideally coupled with intermittent fasting[2] in order to engage/enhance autophagy within the body. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842847/ [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375425/ [2] https://…

The fascinating story of these dualing theories of cancer (somatic vs. metabolic) is told in Tripping Over the Truth: The Metabolic Theory of Cancer [0].

I've read it twice. Strongly recommended.

[0]: https://www.goodreads.com/book/show/23496164-tripping-over-t...

Re: Why cancer cells waste so much energy

#118

Earlier quoted context omitted.

Such treatments attempt to concentrate the radiation and poison where the cancer is, however.

That is not entirely true... The prevalent chemotherapy is detrimental to cells all over the body and it has no way of distinguishing cancel cells vs non-cancer cells. Targeted therapies are different and are becoming more widely used but are still small in percentage of patients compared to "classic" chemotherapy.

Quite some time I had classes on this - but I believe chemo (some at least?) is designed to attack cells with same growth-rate as cancer cells. So they're not attacking just everything in a non-discriminatory fashion - but cells with similar growth as cancer cells, become collateral damage, so to speak.

This is why some chemo will result in for example hairloss; Because the cancer you're being treated for, has the same growth rate as the cells in your hair - and thus the chemo will also kill those cells.

Re: Why cancer cells waste so much energy

#119

Earlier quoted context omitted.

If something is flagged by YouTube, it must be a really bad idea. Chlorine isn’t too bad in terms of toxicity, or it wouldn’t be added to drinking water and freely sold for all sorts of purposes. But there’s absolutely no reason to ingest it (or any other route of administration). I guess it’s exactly because of it’s ubiquity that those of a conspiratorial mindset like it so much: it fits with the idea that there are…

Chlorine sucks. It's added to water because the other major way of disinfecting water (ozone) is too transient to last all the way through the water pipelines. Nonetheless, they're often used in combination, to minimize the amount of chlorine needed. The only thing worse than chlorinated water is the diseases you catch by not having chlorinated water.

This is exactly my point. If anything, the effects of chlorine dioxide seem minimal or barely noticeable compared to chemo, and of course, much better than dying of cancer. I'm not saying that cancer patients should skip chemo, though!

Re: Why cancer cells waste so much energy

#120

Earlier quoted context omitted.

There is a very interesting book around the metabolic route for treating cancer. It's called "Starving cancer" by Jane McLelland. It talks about using over the counter drugs and supplements that have been studied for their metabolic blocking properties for cancer, as well as changing the diet to reduce as much as possible the nutrients that cancer craves the most according to their metabolic phenotype. Most of the ti…

If something is flagged by YouTube, it must be a really bad idea. Chlorine isn’t too bad in terms of toxicity, or it wouldn’t be added to drinking water and freely sold for all sorts of purposes. But there’s absolutely no reason to ingest it (or any other route of administration). I guess it’s exactly because of it’s ubiquity that those of a conspiratorial mindset like it so much: it fits with the idea that there are…

I don't agree with trusting YouTube blindly. I trust my friends and colleagues that have cured their cancer better. Also note that chlorine dioxide is not sodium hypoclorite. It's like comparing salt (which also contains chlorine) with sugar.
Post reply on HN