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Why cancer cells waste so much energy

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Re: Why cancer cells waste so much energy

#61
post #26

Earlier quoted context omitted.

This didn't work for Steve Jobs

He wasn't fasting, he was on fruits diet.

So what is 'allowed'? Because I have been seeing 'low calories' (fruits/carrot juice etc) to nothing, even no water to make sure your digestive system does not trigger at all. I know no-one knows this for sure, but what is the current theory?

Re: Why cancer cells waste so much energy

#62

So the cancer cells went with the non-blocking, albeit slower algorithm. With aerobic, pipelines could get filled with ATP and end up blocking the essential NAD+. So the optimization was a loosely decoupled slower fermentation process over the faster aerobic process. Back pressure avoided and all that. So tempting to go with analogies we are familiar with.

There is a relatively new theory saying that malignant, metastatic cancer cells behave like single cell organisms, and that cancer basically represents an unwanted return to our genetic roots; multicellular organisms used to be single cell organisms a billion years ago and the original genes might carry on within our DNA until today. But they should be switched off. Once they are switched on, the cells will stop coop…

I'm no biologist, but I'd be surprised if this is true.

Genes which are essential the the function of an organism are well conserved relative to silenced genes over long time spans.

This is because mutations happen randomly, and mutations to essential genes in the germline tend to get weeded out, while mutations to silenced genes can get corrupted without affecting the fitness of the offspring. This theory, from the way you've stated it, would require preservation of inactive genes for hundreds of millions of years, only to spring back to action in cancer cells.

Re: Why cancer cells waste so much energy

#63

Earlier quoted context omitted.

He wasn't fasting, he was on fruits diet.

So what is 'allowed'? Because I have been seeing 'low calories' (fruits/carrot juice etc) to nothing, even no water to make sure your digestive system does not trigger at all. I know no-one knows this for sure, but what is the current theory?

If you're fasting for this sort of thing, you do not want an elevated insulin level. High insulin levels disable autophagy pathways.

The best way of doing this, based on years of science, would be, well, to eat nothing for 24+ hours at a time, but make sure you stay hydrated; as in, actually fast. The second best would be to seriously curb your carbs, under 30g a day; also tied for second best is to eat just once a day, none of this unscientific three square meals hogwash.

Three of these together could halt the progress of some cancers, and before the shitstorm that was 2020, scientists were publishing papers involving animal models on this.

Steve Jobs did none of these, and was, sadly, off in la-la land when someone with his money and connections could have had access to next generation scientifically-based treatments. Fruitarianism is, frankly, dangerous.

Re: Why cancer cells waste so much energy

#64
post #38

Earlier quoted context omitted.

When I look at this image [0] it seems to me that muslim countries (which tend to fast once a year, I guess?) and poor countries have fewer cases of cancer. But at least with the poor countries I'm not sure if it's because people die of other reasons before they even could get cancer. [0] https://qph.fs.quoracdn.net/main-qimg-a0728f7c2418f32922558b...

That image doesn't warrant a single synapse of your thought without per capita numbers. And then you can try to find other correlations.

It says "rate per 100000 population" on the top right.

Re: Why cancer cells waste so much energy

#65

Earlier quoted context omitted.

There is a relatively new theory saying that malignant, metastatic cancer cells behave like single cell organisms, and that cancer basically represents an unwanted return to our genetic roots; multicellular organisms used to be single cell organisms a billion years ago and the original genes might carry on within our DNA until today. But they should be switched off. Once they are switched on, the cells will stop coop…

I'm no biologist, but I'd be surprised if this is true. Genes which are essential the the function of an organism are well conserved relative to silenced genes over long time spans. This is because mutations happen randomly, and mutations to essential genes in the germline tend to get weeded out, while mutations to silenced genes can get corrupted without affecting the fitness of the offspring. This theory, from the…

You're assuming that the set of genes that produce multicellular life are largely disjoint from those that produce unicellular life, and that is unlikely to be the case. Much more likely, multicellular life is an incremental set of changes layered on top of unicellular life, and so the only thing required to revert from multicellular back to unicellular is a breakdown in that higher-layer functionality.

If you're not already familiar with them, you might want to look up HeLa cells:

https://en.wikipedia.org/wiki/HeLa

Re: Why cancer cells waste so much energy

#66

I’m curious to see how fasting might influence cancer treatment. I know in other parts of the world it is seen as a legitimate treatment, while also potentially considered to be a hippy dippy homeopathic treatment. Anecdotally it seems you can starve certain cancers to death pretty easily by severely limiting your caloric intake. I sense a relationship between that and this study.

From a non-medical professional's perspective it doesn't seem that strange. Medical treatments for cancer include "let's slowly irradiate you and hope the cancer dies first" and "let's slowly poison you and hope the cancer dies first". "let's slowly starve you to death and hope the cancer dies first" doesn't seem all that different.

Cancer cells are among the fastest growing cells. Limiting available nutrition - specifically for growth - should do them the most damage, is the thinking.

Re: Why cancer cells waste so much energy

#67

So the cancer cells went with the non-blocking, albeit slower algorithm. With aerobic, pipelines could get filled with ATP and end up blocking the essential NAD+. So the optimization was a loosely decoupled slower fermentation process over the faster aerobic process. Back pressure avoided and all that. So tempting to go with analogies we are familiar with.

"The findings suggest that drugs that force cancer cells to switch back to aerobic respiration instead of fermentation could offer a possible way to treat tumors. Drugs that inhibit NAD+ production could also have a beneficial effect, the researchers say." And hopefully that's a path to follow that will help treat/cure some types of cance? This all just barely makes sense to me, but my first question was "Does this h…

I'm waiting for them to suggest starving the cancer. That wouldn't keep the cancer industry going though. X

Re: Why cancer cells waste so much energy

#68

I’m curious to see how fasting might influence cancer treatment. I know in other parts of the world it is seen as a legitimate treatment, while also potentially considered to be a hippy dippy homeopathic treatment. Anecdotally it seems you can starve certain cancers to death pretty easily by severely limiting your caloric intake. I sense a relationship between that and this study.

From a non-medical professional's perspective it doesn't seem that strange. Medical treatments for cancer include "let's slowly irradiate you and hope the cancer dies first" and "let's slowly poison you and hope the cancer dies first". "let's slowly starve you to death and hope the cancer dies first" doesn't seem all that different.

Starved of excess sugar. Not food in general.

Re: Why cancer cells waste so much energy

#69

Earlier quoted context omitted.

He wasn't fasting, he was on fruits diet.

So what is 'allowed'? Because I have been seeing 'low calories' (fruits/carrot juice etc) to nothing, even no water to make sure your digestive system does not trigger at all. I know no-one knows this for sure, but what is the current theory?

The idea would be to have zero caloric inputs.

So water and coffee or tea (without milk, of course) would be fine. You're trying to avoid an insulin response and firing up the entire machinery of digestion.

I think it's non-controversial to say that this starves the cancer cells.

Perhaps less certainly we can also say that digestion demands a lot of resources and is an interrupt for a lot of other processes. When your body has nothing to do for 24-36 hours eventually lower priority tasks get attended to ... like garbage collection.

Re: Why cancer cells waste so much energy

#70
post #64

Earlier quoted context omitted.

That image doesn't warrant a single synapse of your thought without per capita numbers. And then you can try to find other correlations.

It says "rate per 100000 population" on the top right.

thanks, did not see that on mobile. so now we can just skip right on over to how people in those African regions die before they even reach more probable cancer age, it absolutely is more so because of them dying, as you initially pondered. Life expectancy is an average, and that average is less than 60 years old in large regions.
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