Reverse Engineering the Source Code of the BioNTech/Pfizer SARS-CoV-2 Vaccine

Post by robbiep » Fri, Jan 01, 2021, 5:04 AM UTC

krehl wrote: post #39

Can anybody explain why/how the resulting protein is recognized as foreign by the body? It is build using the same components and mechanisms as every other one, right? The body can't have a dictionary of 400.000 known proteins, can it?

The full response here requires a deep dive into the immune system and self tolerance but basically, yeah, the immune system learns how to know what is ‘self’ and what is ‘else’. And this is specific to a person’s actual body (ie the reason someone develops organ rejection in the event of a transplant or can develop graft vs host disease in the event of a stem cell transplant (new immune system attacks body bc it isn’t ‘self’).

It’s really an amazing system

Post by laughingmonkey1 » Thu, Jan 07, 2021, 3:17 PM UTC

fierarul wrote: post #26

zevv wrote: post #25

My knowledge of modern genetic engineering is limited to some popsci literature, so I understand only parts of this story. I was surprside by this part though: "Over many years of experimentation, it was found that if the U in RNA is replaced by a slightly modified molecule, our immune system loses interest. For real. [...] The really clever bit is that although this replacement Ψ placates (calms) our immune system,…

Thank you! I came here to ask the same question. Now that we are producing and injecting industrial quantities of Ψ, any chance this will get incorporated in actual viruses or maybe teach the immune system not to ignore it (or maybe even go crazy about it)?

The article directly addresses that question, saying it's highly unlikely because the viruses don't have the machinery to manufacture it.

Re: Reverse Engineering the Source Code of the BioNTech/Pfizer SARS-CoV-2 Vaccine

Re: Reverse Engineering the Source Code of the BioNTech/Pfizer SARS-CoV-2 Vaccine