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Anti-diarrhoea drug drives cancer cells to cell death

aktuelles.uni-frankfurt.de

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Re: Anti-diarrhoea drug drives cancer cells to cell death

#31

Post by certmd »

Benjammer wrote: post #23
wittyreference wrote: post #22

Earlier quoted context omitted.

Medical doctor.

Just curious, how does an MD end up on Hacker News? Edit: I don't mean this in a gatekeeping way, I honestly was just curious to hear an example of how this happens. Do people outside tech have someone in tech mention the site to them? Do they browse and just read the fraction of articles that aren't about something software related?

Probably the same way a medical article ends up on the front page of hacker news. People have interests outside their area of expertise. Which is good!

Re: Anti-diarrhoea drug drives cancer cells to cell death

#32

Post by curious_fella1 »

wittyreference wrote: post #6

Several classes of opioids have been shown to cause neuronal degeneration via ATF4 activation. So, key points: 1. Loperamide is not unique. I don't know why these researchers have singled it out. Is it because they heard there's an opioid that doesn't get you high? It only avoids getting you high because it doesn't get into the brain. IF you deliver it to the brain to treat a brain tumor, it will get you high. 2. Pat…

> Several classes of opioids have been shown to cause neuronal degeneration

Question for you - is this "brain damage" that I often hear results from taking a particular drug the result of intentful downregulation of certain neuronal receptors (e.g., meth -> too much dopamine in synapse -> downregulate dopamine receptors), or is the drug actually killing brain cells/neurotoxic?

Re: Anti-diarrhoea drug drives cancer cells to cell death

#33

Post by [deleted] »

wittyreference wrote: post #6

Several classes of opioids have been shown to cause neuronal degeneration via ATF4 activation. So, key points: 1. Loperamide is not unique. I don't know why these researchers have singled it out. Is it because they heard there's an opioid that doesn't get you high? It only avoids getting you high because it doesn't get into the brain. IF you deliver it to the brain to treat a brain tumor, it will get you high. 2. Pat…

[deleted]

Re: Anti-diarrhoea drug drives cancer cells to cell death

#34

Post by wittyreference »

ar-jan wrote: post #28
wittyreference wrote: post #6

Several classes of opioids have been shown to cause neuronal degeneration via ATF4 activation. So, key points: 1. Loperamide is not unique. I don't know why these researchers have singled it out. Is it because they heard there's an opioid that doesn't get you high? It only avoids getting you high because it doesn't get into the brain. IF you deliver it to the brain to treat a brain tumor, it will get you high. 2. Pat…

> It only avoids getting you high because it doesn't get into the brain. People do get high on immodium [0]. With huge doses, but still. 0: https://www.forbes.com/sites/robertglatter/2018/01/31/fda-cr...

True. The blood-brain barrier is a relative barrier, not an absolute one. When we say it doesn't have (effect X), we mean "within the normal range of doses."

Re: Anti-diarrhoea drug drives cancer cells to cell death

#35

Post by oblio »

EForEndeavour wrote: post #25
Benjammer wrote: post #23

Earlier quoted context omitted.

Just curious, how does an MD end up on Hacker News? Edit: I don't mean this in a gatekeeping way, I honestly was just curious to hear an example of how this happens. Do people outside tech have someone in tech mention the site to them? Do they browse and just read the fraction of articles that aren't about something software related?

1. Medicine is an ancient tower of hacks upon hacks. 2. Many people have areas of interest outside of their profession.

3. Programming is one of those things you can do as a side-gig/hobby. I'm quite sure you can be a programmer and an MD, but you probably can't be both a theoretical physicist and a neurosurgeon :-p

Re: Anti-diarrhoea drug drives cancer cells to cell death

#36

Post by giantg2 »

wittyreference wrote: post #6

Several classes of opioids have been shown to cause neuronal degeneration via ATF4 activation. So, key points: 1. Loperamide is not unique. I don't know why these researchers have singled it out. Is it because they heard there's an opioid that doesn't get you high? It only avoids getting you high because it doesn't get into the brain. IF you deliver it to the brain to treat a brain tumor, it will get you high. 2. Pat…

Along the same line as your #3... how are they targeting the ER of only the tumor cells and not normal cells?

Re: Anti-diarrhoea drug drives cancer cells to cell death

#37

Post by renewiltord »

Benjammer wrote: post #23
wittyreference wrote: post #22

Earlier quoted context omitted.

Medical doctor.

Just curious, how does an MD end up on Hacker News? Edit: I don't mean this in a gatekeeping way, I honestly was just curious to hear an example of how this happens. Do people outside tech have someone in tech mention the site to them? Do they browse and just read the fraction of articles that aren't about something software related?

My cousin is an MD. I'm a software engineer. His home network is more well-provisioned than mine (IoT stuff on separate VLAN, PiHoles,...). He also has a nicer soldering iron and a DIY voice assistant.

Re: Anti-diarrhoea drug drives cancer cells to cell death

#39

Post by XYZZYBouy »

Benjammer wrote: post #23
wittyreference wrote: post #22

Earlier quoted context omitted.

Medical doctor.

Just curious, how does an MD end up on Hacker News? Edit: I don't mean this in a gatekeeping way, I honestly was just curious to hear an example of how this happens. Do people outside tech have someone in tech mention the site to them? Do they browse and just read the fraction of articles that aren't about something software related?

It's because Dang is an XYXXY boy. Kind of the same way how your next persident get sturck while jaywalking. Shit happend dude. Everything is a curious thing. Just absorb it.

Re: Anti-diarrhoea drug drives cancer cells to cell death

#40

Post by heavyset_go »

Benjammer wrote: post #23
wittyreference wrote: post #22

Earlier quoted context omitted.

Medical doctor.

Just curious, how does an MD end up on Hacker News? Edit: I don't mean this in a gatekeeping way, I honestly was just curious to hear an example of how this happens. Do people outside tech have someone in tech mention the site to them? Do they browse and just read the fraction of articles that aren't about something software related?

People have intersecting interests. For example, Con Kolivas is an anesthesiologist who is also a Linux kernel hacker.
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