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It took two days to develop Moderna’s vaccine

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Re: It took two days to develop Moderna’s vaccine

#131
post #68

Earlier quoted context omitted.

A friend of mine has a partner who works for them. She said that employees don't get a free vaccine. Obviously take this rumor with a grain of salt.

Sorry boss, I broke a vial.

Sterile fill products are done on assembly lines and don’t really get touched by humans until they are are packaged.

Re: It took two days to develop Moderna’s vaccine

#133
post #31

The layman's explanation I've seen about how these mRNA vaccines work is that they get some of your cells to manufacture a protein that is characteristic of the virus, which the cells release and the immune system takes care of. Then later if you get the virus, the immune system already recognizes that protein and takes care of the virus. Question: why do we need to have our cells make the protein? Couldn't we synthe…

1. In 40 years, there have only been 20 protein drugs approved. 2. Yes the cells go back to to normal after the mRNA degrades. The mRNA does not last long, it is like data in ram vs data on a hard drive. See this video: https://www.youtube.com/watch?v=T4-DMKNT7xI

20 protein drugs? mAbs are proteins and hundreds of those have been approved.

Re: It took two days to develop Moderna’s vaccine

#134
post #127

Earlier quoted context omitted.

It’s normal here in NZ and with the exception of borders, restrictions were removed a fair while ago. The economy is considerably better off than most expected too. https://i.stuff.co.nz/business/123696832/gdp-jump-of-14-per-...

Didn't nz had strict lockdown? Also from the article: However, Stats NZ national accounts manager Paul Pascoe said the effects of Covid-19 on different industries had varied “and for some industries these may persist for some time”. The rebound was not enough to make up for the lost activity during the lockdown period, with GDP in the 12 months ended on September 30 down 2.2 per cent on the prior year.

> Didn't nz had strict lockdown?

Yes, and more than one. Community transmission was eliminated several times.

The point is to compare the strategy to others.

Re: It took two days to develop Moderna’s vaccine

#135
post #121

Earlier quoted context omitted.

They probably could have finagled themselves into a trial. I know a friend that got the Moderna vaccine that way. Technically, it was double blind, but it is fairly obvious whether you got the real vaccine or not.

How is it obvious?

What this class of vaccine does is make a bunch of foreign proteins for your immune system to attack in your arm without actually infecting you with the disease. So you get inflammation and soreness at the injection site, and this is not from the physics of having an injection. The placebo arm injects with a saline solution, so there's no immune response, and you miss those symptoms.

Re: It took two days to develop Moderna’s vaccine

#136
post #124

Earlier quoted context omitted.

Another terrible metric comes in here, money. What does the annual flu season cost versus the covid cost? Money is a bad metric but it does boil things down to one measure. I’m sure these aren’t measured the same way but the effects haven’t been similar. Flu $90b per year versus the covid cost of $16t. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885332 https://jamanetwork.com/journals/jama/fullarticle/2771764

> Flu $90b per year versus the covid cost of $16t. I mean that miiiight have something to do with the fact that we basically ignore the flu despite tens of thousands of deaths every year. Whereas with Covid we collectively decided to shut down the entire world.

Yes, and why were the shutdowns done? If you compare what happens with uncontrolled covid spread to a those of a flu season, they aren’t really all that similar. Even with the lockdowns, the deaths have been considerably more than tens of thousands.

Re: It took two days to develop Moderna’s vaccine

#137
post #76

I wonder if any, or if many, Moderna employees have been walking around off-the-books immunized since January. I know I would've been tempted.

What’s the death rate of COVID-19 compared to for example common flu for working age people (30s, 40s)?

For every person who dies of COVID, nineteen people are hospitalized. Eighteen of those will have permanent heart damage. Ten will have permanent lung damage. Three will have strokes. Two will have neurological damage leading to permanent muscular disability. Two will have neurological damage leading to cognitive impairment.

Don't be afraid of covid killing you. Be afraid of it turning you into a mentally disabled cripple who can't catch his breath until you die of heart failure twenty years before your time.

Edit: Oh and just for kicks, there's recent evidence it causes erectile dysfunction too.

Re: It took two days to develop Moderna’s vaccine

#138

The problem is one of medical ethics in an unequal society. The problem is that there's a sum of money for which I would have taken the risk and got a vaccine in January and had exposure to the disease in February. Everyone in society would have been better off if I had been permitted that. America could have paid me and 49 others a million dollars each and come out wayyy ahead (since direct exposure tests will yield…

A few workarounds spring to mind:

1. Run challenge trials, but don't pay participants in money. Talk up the danger and risk, and publicize the heroism of the people who volunteer. Make a spectacle of it. If you ask for fifty heroes, is there any doubt that you'd get them?

2. Pay participants, but impose a minimum price they need to be paid in order to assuage people's squeamishness. That hypothetical guy in sub-Saharan Africa might be exploited at $10, but if he's getting paid $1,000,000 then he has practically won the lottery.

Either of these would be a big improvement over the status quo, where challenge trials aren't run at all and countless people die because of it.

Re: It took two days to develop Moderna’s vaccine

#139

Earlier quoted context omitted.

Probably not since January, but maybe after the phase 1 trials and the dosing schedule was figured out. To be honest, if it doesn't come out that they were using it off the books, either they're suckers or we are.

Would it even be a problem if they did? Like presumably people are generally free to do things to themselves. If they self-administered and they were allowed to consume the resource (e.g., it wasn't theft) who was harmed?

Surely it's either theft or breaks FDA rules?

Re: It took two days to develop Moderna’s vaccine

#140
post #127

Earlier quoted context omitted.

It’s normal here in NZ and with the exception of borders, restrictions were removed a fair while ago. The economy is considerably better off than most expected too. https://i.stuff.co.nz/business/123696832/gdp-jump-of-14-per-...

Didn't nz had strict lockdown? Also from the article: However, Stats NZ national accounts manager Paul Pascoe said the effects of Covid-19 on different industries had varied “and for some industries these may persist for some time”. The rebound was not enough to make up for the lost activity during the lockdown period, with GDP in the 12 months ended on September 30 down 2.2 per cent on the prior year.

I am certain GDP has been nobody’s primary concern in NZ during this time, but -2.2 % is not bad considering how international NZ’s economy is. For comparison, UK is at -9.6 for the same period US -2.9 with a far higher human cost.
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