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Biomarker of Alzheimer's found to be regulated by sleep cycles

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Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#151

Post by dragonwriter »

voisin wrote: post #150
woeirua wrote: post #120

You should take these findings with a big grain of salt. Remember we don't yet even have a causal model of Alzheimer's and dementia. Amyloid plaques are strongly associated with Alzheimer's but it's not clear if they're the actual cause or if they're just a residual indicator that something else has already gone wrong in the brain. As a counterpoint to the amyloid hypothesis, we also see amyloid build ups in patients…

>big grain of salt Isn’t the point of the “grain of Salt” to indicate that it is trivial? If so, then by saying “big grain of salt” aren’t you undermining the point of the original statement? I see this regularly and wonder if I am missing something.

> Isn’t the point of the “grain of Salt” to indicate that it is trivial?

No, it's from an ancient adage about food being mmore easily swallowed when accompanied by salt. The “grain of salt” you take with a dubious statement with is to make it easier to swallow.

A “big grain of salt” is a suggestion that it needs more assistance to be swallowable than a typical target of the saying.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#152

Post by abathur »

dcassett wrote: post #146
eecks wrote: post #105

Earlier quoted context omitted.

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

To add to this, I found something that seems to help when getting to bed - focusing on the visual artifacts that are there with the eyes closed and wondering what's there. Often I will soon not remember anything else, and other times I will be aware that the mind's eye has started creating vivid and detailed imagery, followed by not remembering anything beyond that.

Alas, poor aphantasiacs.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#153

Post by Aeolun »

woeirua wrote: post #120

You should take these findings with a big grain of salt. Remember we don't yet even have a causal model of Alzheimer's and dementia. Amyloid plaques are strongly associated with Alzheimer's but it's not clear if they're the actual cause or if they're just a residual indicator that something else has already gone wrong in the brain. As a counterpoint to the amyloid hypothesis, we also see amyloid build ups in patients…

> As a counterpoint to the amyloid hypothesis, we also see amyloid build ups in patients suffering from sleep apnea, and yet they don't show the hallmark signs of dementia or Alzheimers [1].

I feel like the article doesn’t imply that the amyloid buildup causes the dementia/altzheimers. Just that it makes the effects worse.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#154

Post by pkghost »

dragonwriter wrote: post #151
voisin wrote: post #150

Earlier quoted context omitted.

>big grain of salt Isn’t the point of the “grain of Salt” to indicate that it is trivial? If so, then by saying “big grain of salt” aren’t you undermining the point of the original statement? I see this regularly and wonder if I am missing something.

> Isn’t the point of the “grain of Salt” to indicate that it is trivial? No, it's from an ancient adage about food being mmore easily swallowed when accompanied by salt. The “grain of salt” you take with a dubious statement with is to make it easier to swallow. A “big grain of salt” is a suggestion that it needs more assistance to be swallowable than a typical target of the saying.

And then there are those statements that require a salt lick.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#155

Post by andy_ppp »

suifbwish wrote: post #136
woeirua wrote: post #120

You should take these findings with a big grain of salt. Remember we don't yet even have a causal model of Alzheimer's and dementia. Amyloid plaques are strongly associated with Alzheimer's but it's not clear if they're the actual cause or if they're just a residual indicator that something else has already gone wrong in the brain. As a counterpoint to the amyloid hypothesis, we also see amyloid build ups in patients…

This can be said for a ton of other bio indicators . Similar: does alcohol consumption increase risk of cancer by X percentage or do X percent of alcoholics engage in some cancer causing activity/practice.

Are the sleep cycles of Alcoholics causing them to have weakened immune surveillance for cancerous cells or is it the direct effect of alcohol on the cells that causes them to divide incorrectly?

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#156

Post by chordalkeyboard »

voisin wrote: post #150
woeirua wrote: post #120

You should take these findings with a big grain of salt. Remember we don't yet even have a causal model of Alzheimer's and dementia. Amyloid plaques are strongly associated with Alzheimer's but it's not clear if they're the actual cause or if they're just a residual indicator that something else has already gone wrong in the brain. As a counterpoint to the amyloid hypothesis, we also see amyloid build ups in patients…

>big grain of salt Isn’t the point of the “grain of Salt” to indicate that it is trivial? If so, then by saying “big grain of salt” aren’t you undermining the point of the original statement? I see this regularly and wonder if I am missing something.

I interpret it as emphasizing the colloquialism. Also it seems to wave towards the perceived significance of the statement.

"I heard Marvel is releasing three movies in 2021"

"You should take that with a grain of salt"

"I heard Marvel and DC are doing a Justice League / X-Men crossover in 2021"

"You should take that with a big grain of salt"

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#157

Post by angry_octet »

This is particularly reassuring for those of us with years of crunch projects and jolt cola under our belts (literally).

It's time to reset the culture of crunch. That could start at University, where professors still delight in giving projects due at the same time. This year they seem to give more projects to compensate for lower weight on the exam. Yay covid helps you concentrate!

It's time for engineers to embrace bedtime.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#158

Post by IG_Semmelweiss »

tinco wrote: post #134
eecks wrote: post #105

Earlier quoted context omitted.

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

You're probably right, but it's annoying we need to apply this perfect regime just to fall asleep. Why can't we just be tired in the evening? I have friends who would fall asleep on the couch while watching a movie if it went past 11pm. Meanwhile I have to do some bullshit ww2 pilot exercise just to fall asleep at 1am.

Anecdata: Have kids and a full time job. Play sports. Normal stuff. Problem solved

Before kids it was much much harder to fal asleep. Now i can fall asleep faster than them during sotry time.

Its like night and day. Pun intended

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#159

Post by IG_Semmelweiss »

oarabbus_ wrote: post #127
madrox wrote: post #117

Earlier quoted context omitted.

There's no literature I'm aware of studying links between DSPD and Alzheimer's. However, DSPD is characterized as delayed sleep...not less sleep. As long as you're getting sufficient sleep and feel rested when you do sleep, I don't think it matters when you do it as it relates to this issue. As someone who's dealt with DSPD in his 20s, I'll refrain from advice. I got no end of people telling me to exercise more, drin…

>As long as you're getting sufficient sleep and feel rested when you do sleep, I don't think it matters when you do it as it relates to this issue. I usually sleep 9-10 hours and feel very tired all day. If I sleep 11-11.5 hours, then I'll feel rested, but this rarely happens. Don't get me wrong, there are plenty of days I have an early meeting morning and sleep for 6-7h, but I will feel even more tired than when I s…

You may have apnea. Do a sleep study or get a PC noise detector software that records nighttime noise changrs.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#160

Post by hertzrat »

LinuxBender wrote: post #132
hertzrat wrote: post #119

Earlier quoted context omitted.

I was under the impression that melatonin regulates your sleep wake cycle, and so you take it to do a reset, not to just get to sleep one night

When you consume it as a supplement, you are inducing what your body would normally produce anyway if you are in normal cycles and in the dark. The only difference is dosage. Your body produces very small amounts. Stores sell pills that range from 1mg to 10mg and sometimes even higher. Even 1mg is a lot. That is why they suggest you stop taking it for a couple weeks, every few months. One use of melatonin is to attem…

If you get the melatonin strips that dissolve on your tongue, you can cut them into 1/8ths and the dose becomes more reasonable (0.3ish instead of 3mg)

What you said about adrenaline in the morning - very interesting!

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