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Biomarker of Alzheimer's found to be regulated by sleep cycles

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Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#141

Post by wyclif »

hertzrat wrote: post #118
eecks wrote: post #105

Earlier quoted context omitted.

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

Reminds me of wozniaks advice: https://supermemo.guru/wiki/Curing_DSPS_and_insomnia

Hey, thanks for posting that! It's exactly the information I've been looking for, all in one place.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#142

Post by kurizu4444 »

tinco wrote: post #134
eecks wrote: post #105

Earlier quoted context omitted.

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

You're probably right, but it's annoying we need to apply this perfect regime just to fall asleep. Why can't we just be tired in the evening? I have friends who would fall asleep on the couch while watching a movie if it went past 11pm. Meanwhile I have to do some bullshit ww2 pilot exercise just to fall asleep at 1am.

They probably aren't getting healthy sleep, which is why they fall asleep so easy. They're actually starved of quality sleep

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#143

Post by kick_in_the_dro »

woeirua wrote: post #120

You should take these findings with a big grain of salt. Remember we don't yet even have a causal model of Alzheimer's and dementia. Amyloid plaques are strongly associated with Alzheimer's but it's not clear if they're the actual cause or if they're just a residual indicator that something else has already gone wrong in the brain. As a counterpoint to the amyloid hypothesis, we also see amyloid build ups in patients…

Sorry didn't read the paper linked. Does it say apnea patients don't have higher levels of dementia/Alzheimer's? Perhaps it's because apnea occurs at all ages while these diseases tend to happen later in life?

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#144

Post by realPubkey »

eecks wrote: post #105
oarabbus_ wrote: post #84

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

Daily gym is the only thing that really helped me, which makes the corona lockdown very hard for me, basically staying awake all nights since 6 months.

Thanks for the tip with the sleeping mask, I will try.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#145

Post by decafninja »

eecks wrote: post #105
oarabbus_ wrote: post #84

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

My wife seems to have this but nothing we've tried helps. She wasn't always like this, prior to my meeting her, she spent a few years working at her family's restaurant where her daily schedule would be something like: - Wake up at 10:00AM - Go to work by 11:00AM. - Get off work at 10:30PM. - Eat "dinner" at around midnight-1AM. - 1AM-2/3AM is free time. - Go to sleep at 3AM, rinse repeat.

She was not like this when she worked an office job (fashion designer), but now she can't get back to a "normal" schedule.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#146

Post by dcassett »

eecks wrote: post #105
oarabbus_ wrote: post #84

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

To add to this, I found something that seems to help when getting to bed - focusing on the visual artifacts that are there with the eyes closed and wondering what's there. Often I will soon not remember anything else, and other times I will be aware that the mind's eye has started creating vivid and detailed imagery, followed by not remembering anything beyond that.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#147

Post by clw8 »

glerk wrote: post #133
eecks wrote: post #105

Earlier quoted context omitted.

I wasn't diagnosed with this but I had the symptoms and the consequences you mentioned. It took a long time to fix. Here's some things I tried. Some may have helped or none may have helped. * I bought blackout blinds and use a sleeping mask (sometimes earplugs) * I bought a bright light ( https://www.amazon.co.uk/gp/product/B07FFJYMVS ) and a smart plug. 15 mins before I wanted to wake up I would have a timer turn on…

Have you tried melatonin? I had something similar to this and taking melatonin 1h before my desired bedtime has changed my life.

I have DSPS and 10 mg melatonin works very well for me too.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#148

Post by JamesBarney »

madrox wrote: post #117
oarabbus_ wrote: post #84

What does this mean for people with severe Delayed Phase Sleep Syndrome (DSPS)? I do not feel the need for sleep until usually about 2am, and I find it exceedingly difficult to wake up before 10am. And yes, it's made it extremely difficult to live a "normal" life like your typical person who can wake up at 7am without issue. It's been a problem with relationships, poor performance in school, issues in promotions and…

There's no literature I'm aware of studying links between DSPD and Alzheimer's. However, DSPD is characterized as delayed sleep...not less sleep. As long as you're getting sufficient sleep and feel rested when you do sleep, I don't think it matters when you do it as it relates to this issue. As someone who's dealt with DSPD in his 20s, I'll refrain from advice. I got no end of people telling me to exercise more, drin…

As you know it's hard to get long refreshing sleep when you have DPSD need to be up by 8.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#149

Post by JamesBarney »

bluedevil2k wrote: post #23

I'm curious if sleep aids, whether it's OTC like melatonin or Rx like trazodone and Ambien, can help this situation. Is it just the sleep that's beneficial or is it "natural" sleep (that term doesn't mean anything, but you get the point of it)? In other words, should people who have difficulty sleeping look to aids as a way of staving off dementia later in life.

Trazodone actually increases deep sleep and is associated with reduced risk of dementia.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#150

Post by voisin »

woeirua wrote: post #120

You should take these findings with a big grain of salt. Remember we don't yet even have a causal model of Alzheimer's and dementia. Amyloid plaques are strongly associated with Alzheimer's but it's not clear if they're the actual cause or if they're just a residual indicator that something else has already gone wrong in the brain. As a counterpoint to the amyloid hypothesis, we also see amyloid build ups in patients…

>big grain of salt

Isn’t the point of the “grain of Salt” to indicate that it is trivial? If so, then by saying “big grain of salt” aren’t you undermining the point of the original statement?

I see this regularly and wonder if I am missing something.

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