Am I starting to understand that people with Alzheimer were all part of "hustle culture" when they were younger? Guess we should teach discipline in a different way, or just acknowledge that our socioeconomic circumstances will never materially change - or at least have a real ceiling - outside of complete luck.
Biomarker of Alzheimer's found to be regulated by sleep cycles
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Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#72Earlier quoted context omitted.
We're just going through this with my dad, far fewer resources for the middle class when it come to getting assistance at home. Becoming "purposely financially destitute" sounds like a good strategy but I'm sure it has its own risks.
At least in the UK attempts to gift money to relatives or sell a house to prevent it being sold to pay for social care is seen as "deprivation of assets" in a financial assessment.
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#73I'm currently reading the book, "Why We Sleep (Unlocking the Power of Sleep and Dreams)" right now and I'm stunned by all the new things we ignored when it comes to sleep. There are so many fascinating aspects of our life and body, all governed by Sleep. I highly suggest reading the book to explore more about your sleep.
Be warned, that book is riddled with scientific and factual errors: https://guzey.com/books/why-we-sleep/
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#74I'm curious if sleep aids, whether it's OTC like melatonin or Rx like trazodone and Ambien, can help this situation. Is it just the sleep that's beneficial or is it "natural" sleep (that term doesn't mean anything, but you get the point of it)? In other words, should people who have difficulty sleeping look to aids as a way of staving off dementia later in life.
[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883191/
[1] https://www.nhs.uk/news/medication/widely-used-class-drugs-l...
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#75I believe in 100 years we'll look back in horror at our society's casual indifference to routinely waking adolescents, a group with the latest shifted circadian rhythms, wake up before dawn. Much the same way that we look back at horror with the past's casual indifference to smoking.
I suspect the same will be true about artificial light. Our sleep cycles changed dramatically with the introduction of electric light. A few years back I built an automated lighting system [1] for my apartment that was basically a scaled-up version of a light-based alarm clock [2]. I got the expected benefit, getting up more easily in the morning. But it turned out the bigger benefit was going to sleep at a more regu…
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#76I believe in 100 years we'll look back in horror at our society's casual indifference to routinely waking adolescents, a group with the latest shifted circadian rhythms, wake up before dawn. Much the same way that we look back at horror with the past's casual indifference to smoking.
I think we have it backwards, the problem is going to sleep late.
The early rising == good thing is an old moralism that can't die quickly enough, since it's not fair to people who for whatever genetic reason don't have bodies that behave like that.
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#77I'm curious if sleep aids, whether it's OTC like melatonin or Rx like trazodone and Ambien, can help this situation. Is it just the sleep that's beneficial or is it "natural" sleep (that term doesn't mean anything, but you get the point of it)? In other words, should people who have difficulty sleeping look to aids as a way of staving off dementia later in life.
Melatonin is a hormone that can assist you with falling asleep, but it has no capability to keep you asleep or allow you to reach the 4 stages of deep sleep. Ambien is worse, in that it can make you feel like you are going to sleep, but you will not get into the deep states of sleep required for the brain to detoxify itself. The same is true for weed. Some folks use weed to help themselves sleep, but they are actuall…
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#78I'm curious if sleep aids, whether it's OTC like melatonin or Rx like trazodone and Ambien, can help this situation. Is it just the sleep that's beneficial or is it "natural" sleep (that term doesn't mean anything, but you get the point of it)? In other words, should people who have difficulty sleeping look to aids as a way of staving off dementia later in life.
All cause mortality is absurdly higher if you use drugs to sleep, including OTC stuff[0]. So, probably not. Almost certainly same story with other "meds" that dipshits pop like popcorn[1]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883191/ [1] https://www.nhs.uk/news/medication/widely-used-class-drugs-l...
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#79Earlier quoted context omitted.
> If I sleep LESS (5, 6 hours) I feel better. More energy, lighter on my feet, less depressed. This is a well-known phenomenon, believe it or not. Acute sleep deprivation has a strong anti-depressant effect in people suffering from depression. It can even trigger hypomanic or manic episodes in people who have bipolar disorder. Scientific American wrote a nice article about it several years ago: https://www.scientific…
In studies on wake therapy I've seen, there is a percentage that have long-lasting positive improvement from just one night of sleep deprivation.
Re: Biomarker of Alzheimer's found to be regulated by sleep cycles
#80I believe in 100 years we'll look back in horror at our society's casual indifference to routinely waking adolescents, a group with the latest shifted circadian rhythms, wake up before dawn. Much the same way that we look back at horror with the past's casual indifference to smoking.
Even if children / adolescents have poor sleeping, protocols for mitigating alzheimer’s would be better spent at ages middle age and up. This is when the body’s repair mechanism start failing to keep up and diseases start to progress faster.