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Biomarker of Alzheimer's found to be regulated by sleep cycles

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Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#51

Post by James_Henry »

yunesj wrote: post #5

That’s not surprising at all. From a paper on circadian expression: > We found 43% of all protein coding genes showed circadian rhythms in transcription somewhere in the body, largely in an organ-specific manner. Assuming they looked at more than one protein biomarker, it’s highly likely that one of them would have circadian expression. https://www.pnas.org/content/111/45/16219

It seems like a lot of papers (the ones I end up seeing the headlines of in places like this) like to try and link Alzheimers to sleep. I think these just get attention because everyone sleeps and almost everyone seems to like to complain about their sleep.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#52

Post by throwaway98797 »

dcolkitt wrote: post #50

I believe in 100 years we'll look back in horror at our society's casual indifference to routinely waking adolescents, a group with the latest shifted circadian rhythms, wake up before dawn. Much the same way that we look back at horror with the past's casual indifference to smoking.

only 100 years ago most would be waking up before dawn to milk the cows.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#53

Post by mike_d »

snikeris wrote: post #38
bluedevil2k wrote: post #23

I'm curious if sleep aids, whether it's OTC like melatonin or Rx like trazodone and Ambien, can help this situation. Is it just the sleep that's beneficial or is it "natural" sleep (that term doesn't mean anything, but you get the point of it)? In other words, should people who have difficulty sleeping look to aids as a way of staving off dementia later in life.

The first line of treatment is CBT-I.

CBT-I is psychotherapy targeted at treating one specific cause of insomnia. It does not address any of the physical ailments that may also lead to sleep disorders.

If you aren't careful, you'll lose your internet medical license with such bold medically unsound claims.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#54

Post by peacefulhat »

throwaway98797 wrote: post #52
dcolkitt wrote: post #50

I believe in 100 years we'll look back in horror at our society's casual indifference to routinely waking adolescents, a group with the latest shifted circadian rhythms, wake up before dawn. Much the same way that we look back at horror with the past's casual indifference to smoking.

only 100 years ago most would be waking up before dawn to milk the cows.

most in 1920?

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#55

Post by rtx »

dcolkitt wrote: post #50

I believe in 100 years we'll look back in horror at our society's casual indifference to routinely waking adolescents, a group with the latest shifted circadian rhythms, wake up before dawn. Much the same way that we look back at horror with the past's casual indifference to smoking.

I think we have it backwards, the problem is going to sleep late.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#56

Post by mike_d »

mbesto wrote: post #33
PragmaticPulp wrote: post #14

Earlier quoted context omitted.

It's a great book for emphasizing the importance of sleep. The author's desired outcome is to get people interested in healthy sleep habits, and he hits a home run in that regard. However, take some of the science positions in the book with a grain of salt. The author is notorious for being directionally correct in his opinions, but exaggerating a lot of the science for dramatic effect. This doesn't matter at all if…

> However, take some of the science positions in the book with a grain of salt. The author is notorious for being directionally correct in his opinions, I've read it and I agree. Although he does admit in the beginning that there basically is not much conclusive facts about sleep, hence his motivation for writing the book. It's implied that what he is saying is fact, and its a lot more correlation than I think panace…

> the JRE podcast is actually pretty good at summarizing whats in the book

Anyone who expects to learn something from a Joe Rogan podcast should understand that it is for the most part, a podcast where people go to have their ideas go unchallenged: https://www.vice.com/en/article/9kv9qd/the-joe-rogan-experie...

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#57

Post by throwaway98797 »

peacefulhat wrote: post #54
throwaway98797 wrote: post #52

Earlier quoted context omitted.

only 100 years ago most would be waking up before dawn to milk the cows.

most in 1920?

I’m directionally correct.

You’re right though.

Point stands if I make it 200 years ago and more importantly for most of human history.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#58

Post by treeman79 »

throwaway98797 wrote: post #52
dcolkitt wrote: post #50

I believe in 100 years we'll look back in horror at our society's casual indifference to routinely waking adolescents, a group with the latest shifted circadian rhythms, wake up before dawn. Much the same way that we look back at horror with the past's casual indifference to smoking.

only 100 years ago most would be waking up before dawn to milk the cows.

And in bed at sundown.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#59

Post by solids »

rtx wrote: post #55
dcolkitt wrote: post #50

I believe in 100 years we'll look back in horror at our society's casual indifference to routinely waking adolescents, a group with the latest shifted circadian rhythms, wake up before dawn. Much the same way that we look back at horror with the past's casual indifference to smoking.

I think we have it backwards, the problem is going to sleep late.

The problem is not listening to our body requests. If you are tired, you should you sleep, and then avoid alarms to wake up.

Re: Biomarker of Alzheimer's found to be regulated by sleep cycles

#60

Post by wpietri »

dcolkitt wrote: post #50

I believe in 100 years we'll look back in horror at our society's casual indifference to routinely waking adolescents, a group with the latest shifted circadian rhythms, wake up before dawn. Much the same way that we look back at horror with the past's casual indifference to smoking.

I suspect the same will be true about artificial light. Our sleep cycles changed dramatically with the introduction of electric light.

A few years back I built an automated lighting system [1] for my apartment that was basically a scaled-up version of a light-based alarm clock [2]. I got the expected benefit, getting up more easily in the morning. But it turned out the bigger benefit was going to sleep at a more regular hour thanks to lights that dimmed in the evening. It turned out that previously I just wasn't a responsible lightswitch user: if the lights were on and I was doing something interesting, I'd blow my sleep schedule out. Now, though, that almost never happens. I think it's had significant mood and health benefits.

For those interested, the history podcast BackStory had a great set of stories on how time and sleep have changed in the industrial era. [3] I expect we'll be undoing a lot of that over coming decades.

[1] https://github.com/wpietri/sunrise

[2] an older version of this: https://www.amazon.com/Philips-Simulation-Headspace-Subscrip...

[3] https://www.backstoryradio.org/shows/on-the-clock-4/

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