http://www.pnas.org/lookup/doi/10.1073/pnas.1915006117
You might think that it's possible to use machine learning to predict whether people will be successful using established socio-demographic, psychological, and educational metrics. It turns out that it's very hard and simple regression models outperform the fanciest machine learning ideas for this problem.
The way this study was done is also interesting and paves the way for new kinds of collaborative scientific projects that take on big questions. It draws on communities like Kaggle, but applies it to scientific questions not just pure prediction problems.