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Pfizer Covid vaccine approved for use next week in UK

bbc.com

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Re: Pfizer Covid vaccine approved for use next week in UK

#511

Post by alex504 »

djsumdog wrote: post #441
abootstrapper wrote: post #435

Earlier quoted context omitted.

Risk of long term covid side effects seems greater to me than long term vaccine side effects.

Why do you believe this out of curiosity? Every single "long term covid" symptom study I've read are case studies. The UK one from the publication in Charlottesville covered 60 distinct people and they were all either high risk workers or over 55. We don't know what "permanent damage" is actually happening. I remember having pneumonia in the 90s and it took my lungs over 3 months to recover, and that's from a normal…

I am not a doctor but normal pneumonia recovery doesn't cause myocarditis, memory loss, abnormal liver function, kidney damage or gastrointestinal damage.

It seems very likely at this point that COVID is a disease of the blood vessels, which has the potential to do some really nasty damage to your organs. The numbers are hard to estimate but I've seen experts say that they think about 5 times the number of people who die will have enough problems to be considered having a long term disability. With estimates of case fatality being about .5% - 1.5% that would mean about 5% of the people who get it will have enough long term damage to be disabled.

Re: Pfizer Covid vaccine approved for use next week in UK

#512

Post by willturman »

napier wrote: post #484
maxerickson wrote: post #429

Earlier quoted context omitted.

You just have to identify them. I also wonder if a social butterfly has a bigger contact network than the average church goer or retail employee.

Smartphone mobility and social graph data that’s already being collected and analyzed. Rather than just using existing tech to target ads and build surveillance capitalism profiles, it could be used in the public interest. On an opt in basis naturally; but as frictionlessly as possible via cookie tracker popups and updates to FAANG terms of service perhaps.

"Based on tracking your GPS and behavior on Facebook, we need you to come in for an injection."

Where do I sign up?!

Re: Pfizer Covid vaccine approved for use next week in UK

#513

Post by nfg »

sschueller wrote: post #353
jakozaur wrote: post #19

In terms of rollout. UK is the ideal country to be the first: 1. Heavily impacted by Covid-19. 2. Centralised health care system makes it easier to compare results and efficiency. E.g. it's UK which figured out that dexamethasone is efficient against Covid https://www.who.int/news/item/16-06-2020-who-welcomes-prelim... 3. Developed country with great logistics.

4. Is an island that can be cut off incase of a zombie apocalypse...

The UK is not an island.

Re: Pfizer Covid vaccine approved for use next week in UK

#514

Post by Toenex »

d_tr wrote: post #357
sweezyjeezy wrote: post #175

Earlier quoted context omitted.

We don't need the super-high efficacy numbers (>90%) that the other vaccines are reporting for this to stop the virus. Typical flu vaccines are ~ 50%, I think the Oxford vaccine's results show that they've achieved this.

The efficacy does not need to be super-high, provided enough people decide to actually go get vaccinated, and the percentage of skeptical people seems to be quite high. Plus, any given vaccinated individual would have to rely less on others being vaccinated as well. But I am grateful that vaccines got developed and tested so quickly anyway.

Yes I think they only need to hit 50% for approval. Conservatively they were getting 62% as I recall and the 'experimental endpoint' dose got them to 90%.

The Oxford vaccine is far cheaper (15x) and easier to store so long term it has a lot of competitive advantages.

Re: Pfizer Covid vaccine approved for use next week in UK

#515

Post by Toenex »

KingOfCoders wrote: post #347
spuz wrote: post #305

Earlier quoted context omitted.

This doesn't matter though. The results are still valid.

How could numbers in a "controlled" trial be valid if they are arrived at by accident?

The half dose was an 'experimental endpoint'. Always planned but not seen as critical. FDA rules now stipulate you can only register on primary endpoints declared before the trial starts. I suspect AZ have argued that the accelerated nature of the process should take this into account.

Re: Pfizer Covid vaccine approved for use next week in UK

#516

Post by throwaway3699 »

sbilstein wrote: post #478
throwaway3699 wrote: post #355

Earlier quoted context omitted.

Yeah, the only reason I'm holding to the guidelines is for elderly and immunocompromised. I don't care about catching covid and nor anybody I know not in one of those categories. This whole thing becomes moot once the vulnerable are vaccinated, no need for creepy immunity passports.

I used to agree but a few of my 20-29 year old friends have had much worse experiences than expected. One had some neurological side effects, which is rare but happens, that affected his eye movement and made it impossible for him to read or work comfortably. It wasn't healing and it turned out he had an undetected issue processing folic acid I believe, which has an effect on how your body heals from neurological dam…

There are much more dangerous things to worry about in life. I'm happy to take chances with Covid, the only thing I won't do is risk hurting others.

Re: Pfizer Covid vaccine approved for use next week in UK

#517

Post by foolfoolz »

djsumdog wrote: post #441
abootstrapper wrote: post #435

Earlier quoted context omitted.

Risk of long term covid side effects seems greater to me than long term vaccine side effects.

Why do you believe this out of curiosity? Every single "long term covid" symptom study I've read are case studies. The UK one from the publication in Charlottesville covered 60 distinct people and they were all either high risk workers or over 55. We don't know what "permanent damage" is actually happening. I remember having pneumonia in the 90s and it took my lungs over 3 months to recover, and that's from a normal…

theres a huge hysteria market for this virus. it seemed like at one point and article was coming out weekly saying long term effects were worse and worse and worse. i don’t believe it

Re: Pfizer Covid vaccine approved for use next week in UK

#518

Post by JamisonM »

djsumdog wrote: post #441
abootstrapper wrote: post #435

Earlier quoted context omitted.

Risk of long term covid side effects seems greater to me than long term vaccine side effects.

Why do you believe this out of curiosity? Every single "long term covid" symptom study I've read are case studies. The UK one from the publication in Charlottesville covered 60 distinct people and they were all either high risk workers or over 55. We don't know what "permanent damage" is actually happening. I remember having pneumonia in the 90s and it took my lungs over 3 months to recover, and that's from a normal…

For me personally the unknowns of such a new virus mean that the existence of the case studies would be enough to be concerned. And the strongest case is made by the fact that this virus' closest relative known to infect humans has caused lasting damage to people with cases that lead to hospitalization:

https://www.nature.com/articles/d41586-020-02598-6

"Evidence from people infected with other coronaviruses suggests that the damage will linger for some. A study published in February recorded long-term lung harm from SARS, which is caused by SARS-CoV-1. Between 2003 and 2018, Peixun Zhang at Peking University People’s Hospital in Beijing and his colleagues tracked the health of 71 people who had been hospitalized with SARS. Even after 15 years, 4.6% still had visible lesions on their lungs, and 38% had reduced diffusion capacity, meaning that their lungs were poor at transferring oxygen into the blood and removing carbon dioxide from it."

We know this much and SARS is poorly studied because it faded away so we generally lost interest in it. This virus is both similar and different enough to be very, very wide spread so even minor negative effects over the total population that gets moderate to mild cases will have the potential to have very large impacts on worldwide health.

As time goes on we are going to better document the consequences of mild and moderate cases and understand these things better, caution seems advisable until we do.

Re: Pfizer Covid vaccine approved for use next week in UK

#520

Post by napier »

aspyct wrote: post #510
tubularhells wrote: post #476

Earlier quoted context omitted.

This place is a drop in replacement for r/asd.

Yeah uhm... Never been to /r/asd, and now I'm slightly afraid of checking it out, seeing as two comments have been deleted :D

Some people’s insecurities make them allergic to (admittedly tenuous) attempts at humor in face of absurdities and so they downvote as if they’re on Reddit.
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