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No one who got Moderna's vaccine in trial developed severe Covid-19

sciencemag.org

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Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#341

Post by reaperducer »

lokar wrote: post #319
tpmx wrote: post #83

Earlier quoted context omitted.

Relevant criteria for the question "does it it exclude old, fragile people with various common pre-existing conditions?" (not exhaustive, but indicative): Included: Pre-existing conditions are okay as long as they are in a stable condition (defined as no significant change in therapy etc for the 3 months before enrollment). Excluded: Immunosuppressive or immunodeficient state, asplenia, recurrent severe infections (H…

Almost 40,000 people got an organ transplant in the US in 2019

And almost 140,000 people got COVID in the US yesterday.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#342

Post by SpicyLemonZest »

SomeoneFromCA wrote: post #164
SpicyLemonZest wrote: post #75

Earlier quoted context omitted.

Most Americans think gathering for Thanksgiving and Christmas is both altruistic and very important. Selfishly, I would have preferred to stay home and call in, but my mom didn't want to be alone on Thanksgiving so I drove down to be with her. They're perhaps not necessary in the strict sense of the word, but health authorities have consistently said that very important gatherings are okay as long as you try to do th…

This is so strange and alien to me - go visit older mother, and potentially infect her. Health authorities, meanwhile, consistenly said - if you can avoid Thanksgiving, do it.

And the opposite is strange and alien to me. I wish I knew a way to bridge the conceptual gap here, because it's been coming up a lot and I've never seen anyone successfully forge a common understanding.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#343

Post by SomeoneFromCA »

papa_bear wrote: post #323
SomeoneFromCA wrote: post #11

Earlier quoted context omitted.

I know all that. Besides, one pedantic point - antisense are not the same to typical mRNA, they have thiophosphate group instead of normal phosphate in their backbone, or some other tweak to make them bind mRNA permanently.

Some of us don't know, so the extra detail is appreciated :) Interesting re: the thiophosphate group. It sounds like it just floods your body with some mRNAs complementary to the viral mRNA that blocks it from getting turned into proteins by your cells' ribosomes?

Yes, pretty much; almost like NOPing out code in binary patches. However double check about the thiophosphates. I might be wrong. It is either Morpholinos are blockers and thios are promoting destruction of the mRNA or the opposite.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#344

Post by projektfu »

orblivion wrote: post #316
projektfu wrote: post #301

Earlier quoted context omitted.

AZD1222, the AstraZeneca covid vaccine, uses an adenoviral vector to deliver DNA to human cells that then produce the desired viral proteins to present to the immune system. https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

This is a bit much for me to read without the right background. I'll focus on your claim, though. "Sending mRNA to human cells to produce viral proteins" describe how all of the other vaccines work. You're saying that this one uses DNA. I don't know if that's a typo or if that's an important difference. However from what I understand, the two other vaccines people are talking about don't change any of the genetic mat…

Yes, this one uses a DNA virus as a way to deposit a piece of DNA into the nucleus of a cell, so that it makes viral proteins the way cells usually do. The virus used is incapable of replication so it only has the cell entry features, not the viral propagation features.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#345

Post by dopylitty »

I don’t see it in the article but the majority of the work for this and other mRNA vaccines was done by a lab at the US government NIH which has been working on stabilizing coronavirus spike proteins for years now in collaboration with university labs. Moderna and other companies have supplied the platforms for distributing the mRNA coding the protein. There’s a great lecture [1] from an NIH researcher that covers this history.

1. https://youtu.be/xpqfdr9FPWM

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#346

Post by tinus_hn »

mattkrause wrote: post #240
mam2 wrote: post #228

Earlier quoted context omitted.

Yeah how would they find anyone careless enough aged more than 65 who would accept to 1/ take the vaccine 2/ expose himself to the virus to chekc his immunity. We will never know before trial

None of these trials have used a "challenge" design where people were deliberately exposed to the virus. Instead, they vaccinate a ton of people and then let them go about their lives. Participants' risk of getting COVID shouldn't go up, unless participating in the trial induces them to behave more riskily.

That wouldn’t be smart because they don’t get to know if they got the vaccine or the placebo.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#347

Post by Noos »

MacsHeadroom wrote: post #102
jimbob45 wrote: post #80

Earlier quoted context omitted.

> “This is a unique situation where we as a company simply cannot take the risk if in ... four years the vaccine is showing side effects,” Ruud Dobber, a member of Astra’s senior executive team, told Reuters. Seems pretty straightforward to me. It’s an unproven method of vaccine creation and hasn’t been tested by anyone. I really can’t imagine this holding up in courts though.

In the US it's not possible to sue for damages caused by vaccines. I'm sure the courts will find a way to make it work. The concern seems to be that stifling vaccine development for the benefit of a few just isn't worth the risk of future plagues.

We already have something I think, the National vaccine Injury Compensation program

https://www.hrsa.gov/vaccine-compensation/index.html

Essentially the government runs the trial.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#348

Post by CincinnatiMan »

danmg wrote: post #91
ck2 wrote: post #8

Yeah but imagine being dumb enough to get infected and very sick over the next month before you can get both shots next year. Because there are going to be thousands, maybe millions who do that in the USA alone for no good reason.

I just recovered from it. I'm pretty sure I got it walking out of a grocery store. I was wearing a mask, and was walking by another older man who was also wearing a mask and standing at the exit. He was hacking and coughing so hard that the mask did nothing. I tried to hold my breath as I got until I got outside, but it was to no avail. About four days later, I developed flu like symptoms. Sometimes, it doesn't matte…

Did you get tested and verify it was COVID? Just making sure because sometimes commenters claim they had it but never actually got tested haha.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#349

Post by danmg »

CincinnatiMan wrote: post #348
danmg wrote: post #91

Earlier quoted context omitted.

I just recovered from it. I'm pretty sure I got it walking out of a grocery store. I was wearing a mask, and was walking by another older man who was also wearing a mask and standing at the exit. He was hacking and coughing so hard that the mask did nothing. I tried to hold my breath as I got until I got outside, but it was to no avail. About four days later, I developed flu like symptoms. Sometimes, it doesn't matte…

Did you get tested and verify it was COVID? Just making sure because sometimes commenters claim they had it but never actually got tested haha.

Yes. I got a PCR test that came back positive.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#350

Post by ab3rC1te »

Is COVID real? Yes! Is is really that bad as everyone makes it out to be? No! If it was that deadly of a virus, 9 out of 10 people would be dead by now. Do you need a vaccine? Nope, unless you want to take one and die. I have only been sick one time, and that was during Dec to Feb of 2019 when every human being was exposed to COVID. Have I wore a mask this entire time? No! Have I went and got tested? No! Will I go get tested? No! If man would quit playing GOD, there would be no diseases to fabricate vaccines for people to take. Ultimately it merely becomes a money racket to align the rich pharmaceutical companies with power and control. And as for cancer, that's man made and there's a cure for that as well.
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