121–130 of 436 posts
Does anybody have a good link for a layman's overview of how mRNA vaccines work? Lot's of nervousness from people around this, and would love to be able to help quell some of that.
Earlier quoted context omitted.
There may be other ways to reduce risk if you belong to the at risk population, though. Those statistics all have to be taken with a grain of salt. Like if it says "x% of some population will die from some thing", it could mean "x% in the population tend to be reckless" (like "x% of people under 30 will die from base jumping", but it is easy to avoid by not doing base jumping). In the case of Covid, perhaps not livin…
There may be in general, but in this case I don't think it's a factor. Something like 40% of deaths have happened in nursing homes, where residents don't have much agency to reduce their individual risk.
Earlier quoted context omitted.
With this being the case, how does it even make sense for companies like Ticketmaster and Quantas to announce that they'll require their customers to be vaccinated? Yeah, 90-95% of your customers won't have symptoms if they get infected. But they'll still have the ability to pass on that infection to someone who wasn't vaccinated, or falls into the 5-10% of people who the vaccine isn't effective for. Obviously the va…
>With this being the case, how does it even make sense for companies like Ticketmaster and Quantas to announce that they'll require their customers to be vaccinated? This is such a weird take imo. There is no need to vaccine non-risk people afaik. I thought the whole deal with covid is how mild it is for the general population but deadly for a subset of it.
Earlier quoted context omitted.
Relevant criteria for the question "does it it exclude old, fragile people with various common pre-existing conditions?" (not exhaustive, but indicative): Included: Pre-existing conditions are okay as long as they are in a stable condition (defined as no significant change in therapy etc for the 3 months before enrollment). Excluded: Immunosuppressive or immunodeficient state, asplenia, recurrent severe infections (H…
I think (from my parents and in-laws) that immunosuppression is normally associated with current cancer treatment. So, for example, it looks like this protocol would exclude people getting chemotherapy. Happy to be proven wrong on this by someone with more information.
I don't know how many people with conditions take immunosuppression medication. I take it for arthritis and alopecia and have come across many people on similar meds for diabetes or other things. But that could be a form of confirmation bias
Earlier quoted context omitted.
Can read all of them in their published protocol at https://www.modernatx.com/sites/default/files/mRNA-1273-P301... under section 5.2.
Relevant criteria for the question "does it it exclude old, fragile people with various common pre-existing conditions?" (not exhaustive, but indicative): Included: Pre-existing conditions are okay as long as they are in a stable condition (defined as no significant change in therapy etc for the 3 months before enrollment). Excluded: Immunosuppressive or immunodeficient state, asplenia, recurrent severe infections (H…
Earlier quoted context omitted.
With this being the case, how does it even make sense for companies like Ticketmaster and Quantas to announce that they'll require their customers to be vaccinated? Yeah, 90-95% of your customers won't have symptoms if they get infected. But they'll still have the ability to pass on that infection to someone who wasn't vaccinated, or falls into the 5-10% of people who the vaccine isn't effective for. Obviously the va…
>With this being the case, how does it even make sense for companies like Ticketmaster and Quantas to announce that they'll require their customers to be vaccinated? This is such a weird take imo. There is no need to vaccine non-risk people afaik. I thought the whole deal with covid is how mild it is for the general population but deadly for a subset of it.
Earlier quoted context omitted.
I'm curious what those rare cases are.
Viruses! RNA viruses like SARS-cov-2. They make the cell reverse transcribe their RNA cargo into DNA, and then the cell produces more viruses.
But also - that's reverse transcription, not reverse translation. Maybe Lupe made this point a little too late in his description.
EDIT: Sorry, moved around the above after rethinking
Earlier quoted context omitted.
Those 2 numbers aren’t comparable. A 1% death rate with a disease as contagious as COVID means more than 50 million dead globally at some point (not everyone will get it but the majority will eventually). Near universal vaccination with a vaccine that is 95% effective at preventing severe cases means saving 47.5 million lives in that scenario. Despite the disease having a 99% survival rate. If the vaccine provides st…
That is not quite the case as the you're double counting quite a number of people. set A = The set of all people who die from covid set B = The set of people who were going to die that year from cancer, heart, age etc Nearly all of set A fits inside set B. For evidence see either CDC or even the Italian health ministry data set they even published as far back as April 2020 where the median age of death was 79 and 50%…
That means that COVID is still more deadly than the Flu, and some large percentage of people will still choose to remain home, stop traveling, stop eating out etc...
These people will continue to damage the economy until an effective vaccine is available. And even in your scenario a vaccine that is 95% effective will still save millions of lives.
An effective vaccine will save lives, and it will improve the economy. There is no logical reason to deny that fact.
[1] https://wellcomeopenresearch.org/articles/5-75 [2] https://www.medrxiv.org/content/10.1101/2020.06.08.20050559v...
note there is not a claim this vaccine prevents infection, only lessens symptoms, meaning you are still contagious. "We all expect an effective vaccine to prevent serious illness if infected. Three of the vaccine protocols—Moderna, Pfizer, and AstraZeneca—do not require that their vaccine prevent serious disease only that they prevent moderate symptoms which may be as mild as cough, or headache." "Prevention of infec…
With this being the case, how does it even make sense for companies like Ticketmaster and Quantas to announce that they'll require their customers to be vaccinated? Yeah, 90-95% of your customers won't have symptoms if they get infected. But they'll still have the ability to pass on that infection to someone who wasn't vaccinated, or falls into the 5-10% of people who the vaccine isn't effective for. Obviously the va…
note there is not a claim this vaccine prevents infection, only lessens symptoms, meaning you are still contagious. "We all expect an effective vaccine to prevent serious illness if infected. Three of the vaccine protocols—Moderna, Pfizer, and AstraZeneca—do not require that their vaccine prevent serious disease only that they prevent moderate symptoms which may be as mild as cough, or headache." "Prevention of infec…
With this being the case, how does it even make sense for companies like Ticketmaster and Quantas to announce that they'll require their customers to be vaccinated? Yeah, 90-95% of your customers won't have symptoms if they get infected. But they'll still have the ability to pass on that infection to someone who wasn't vaccinated, or falls into the 5-10% of people who the vaccine isn't effective for. Obviously the va…