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No one who got Moderna's vaccine in trial developed severe Covid-19

sciencemag.org

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Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#41

Post by khuey »

mchusma wrote: post #19

FDA says Dec 17 meeting to discuss. This contradicts some earlier opinions that the reason the FDA was taking so long to review Pfizer (Dec 10 scheduled date) was that they were planning to review 2-3 candidates together. For context, scheduling the meeting to review the candidates is running at 5-10% of the development time for these vaccines. 20M vaccines represent about 1/3 the elderly population in the US, there…

While I agree that we should have moved faster, even if you approved a vaccine candidate in days it's not clear who you'd vaccinate in a targeted campaign to "complete prevent" the pandemic.

Being able to produce vast quantities of this stuff rapidly is ultimately going to be at least as important as streamlining the regulatory process. After almost a year we don't have even a fraction of what we need to vaccinate the population.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#42

Post by hobs »

ed25519FUUU wrote: post #32
delfinom wrote: post #24

Earlier quoted context omitted.

Sadly from the manufacturing process description alone, we are going to be decades away from when it's actually ...not a few million dollars per individual to treat.

If it cures late stage cancer a few million per treatment would actually be a bargain. Edit: I have no clue why people would rather something not exist than for something to exist but for it to be too expensive.

Considering that no, we dont have a few million per person than no, its not really a "bargain" unless you mean in the context of a pact with the devil.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#43

Post by function_seven »

philshem wrote: post #28
function_seven wrote: post #18

Earlier quoted context omitted.

I think the downvotes are from people assuming you're denouncing the placebo portion of a randomized clinical trial? Maybe indicate otherwise? (Or explicitly state it if I'm wrong). All of those that died during clinical trials deserve respect for signing up and helping us advance the medicine. Their death is a statistic, but not in the Stalin quote sense! It's a statistic that helped us find the treatment that will…

not sure what you mean "denouncing the placebo portion of a randomized clinical trial" but I'm going to move on with my life and accept my -4 reputation :)

I meant that your original comment could have been read to imply that this placebo-recipient died a needless death. (e.g. "They should have just given him the vaccine!")

I didn't read it that way, but I could see how others would.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#44

Post by packetlost »

ed25519FUUU wrote: post #32
delfinom wrote: post #24

Earlier quoted context omitted.

Sadly from the manufacturing process description alone, we are going to be decades away from when it's actually ...not a few million dollars per individual to treat.

If it cures late stage cancer a few million per treatment would actually be a bargain. Edit: I have no clue why people would rather something not exist than for something to exist but for it to be too expensive.

Sure, but that doesn't make it any more affordable for the average person.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#45

Post by lultimouomo »

amurale wrote: post #36

> No one developed severe Covid-19 > No one developed severe adverse effects (yet) There is a reason vaccine trials normally take several years. I'll wait until we're a few years into phase IV trials, thankyouverymuch.

Honest question: would you wait if there was a pact to the effect that either everyone takes the vaccine, or no one does?

Because obviously not getting vaccinated when everybody else does is almost always the best choice game-theoretically speaking; it doesn't really say anything on the vaccine (it may say more on the civic sense of the individual).

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#46

Post by philshem »

function_seven wrote: post #43
philshem wrote: post #28

Earlier quoted context omitted.

not sure what you mean "denouncing the placebo portion of a randomized clinical trial" but I'm going to move on with my life and accept my -4 reputation :)

I meant that your original comment could have been read to imply that this placebo-recipient died a needless death. (e.g. "They should have just given him the vaccine!") I didn't read it that way, but I could see how others would.

ah ok, I get it now. thanks.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#47

Post by renewiltord »

philshem wrote: post #7

>>> Anti-vaxxers immediately jump on any report of possible adverse events in a vaccine trial (which are thoroughly investigated, of course). >>> Let’s spare a thought today for the person who signed up for the Moderna vaccine trial, received two placebo shots and died of covid19. https://twitter.com/kakape/status/1333401133260419072 --- edit: Please explain the downvotes. The vaccine volunteer would be alive if he w…

Downvoting for following reasons:

* Not interesting. Placebo.

* Low quality source: personal Twitter

* Cannot find corroboration

* Unclear why you think this is interesting to us. I don't understand whether you're making a point

Hope that helps

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#49

Post by newdude116 »

Thats good but I would not be overly optimistic.

Two question since I dont know much about mRNA vaccines

1. The mRNA has to express the target Protein for the Anitbodies. If injected, how does this happen? It has to go somehow into the cell to be translated? Or is the delivery vehicle the magic sauce?

2. What makes mRNA vaccines so special? What is the difference of injecting the expressed protein sequence directly?

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#50

Post by lultimouomo »

IronRanger wrote: post #21

What was the age profile of the trial? If you fill it with healthy people under 50 during Summer you would expect the same results with a placebo, given the profile of the virus.

Second paragraph in the article, it says there were 30 severe COVID cases in the placebo group; unless there trial was ridiculously botched the age profiles of the intervention and trial branch are going to be identical. With the reasonable caveat that definitive answer can only be given once we have read the full trial report.
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