911–920 of 1001 posts
No significant side effects so far tested. I'm always curious what the long term side effects will be, and we won't know that for years.
Well that settles it then. We’ll just wait for a few more years to see what the long term side effects are.
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While it's a minor logistical challenge, it's simple enough to ship this in a liquid nitrogen dewar. Even very small cities will have liquid nitrogen facilities. Shipping from the nearest city to most of the population sounds very doable in 24 hours. Remember you only need to get most of the population to halt the spread. If there's some tiny village 3 days hike away in the rainforest, you can skip them.
Shipping hundreds of thousands of doses of vaccine at -80C is more than a “minor logistical challenge”. First, you’d never ship in a liquid nitrogen dewar. It would be a massive logistics bottleneck considering the weight of dewars and the volume you'd be shipping (Pfizer already has deals secured for hundreds of millions of doses). And plus, these are packaged vaccines - a glass vial with a label, in a paper box, wi…
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Shipping hundreds of thousands of doses of vaccine at -80C is more than a “minor logistical challenge”. First, you’d never ship in a liquid nitrogen dewar. It would be a massive logistics bottleneck considering the weight of dewars and the volume you'd be shipping (Pfizer already has deals secured for hundreds of millions of doses). And plus, these are packaged vaccines - a glass vial with a label, in a paper box, wi…
This is a fundamentally easy thing to solve. Developing a safe and effective vaccine -- fundamentally hard. Developing a nuclear weapon -- fundamentally hard. Developing a quantum computer -- fundamentally hard. Shipping something cold at a large scale? Hard, but not fundamentally hard. We'll solve it. There's no fucking way the vaccine effort is stopped by refrigeration needs.
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My understanding is that the -80C storage is most likely simply because they haven't tested at higher temperatures yet.
Probably due to DNA storage because I used to work with genomics and we had the same temps
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I think we can eradicate it by contact tracing. With 90% efficiency it will be extremely tough for the virus to spread. For any new cases you simply test everyone in the vicinity of the infected person. But I don't think even that will be necessary. 90% efficiency reduces R so much, it will probably die out on its own. The real problem is mutations that are not covered by the vaccine. If it mutates as efficiently as…
> With 90% efficiency it will be extremely tough for the virus to spread Aren't you assuming 100% coverage at 90% effectiveness? What if it's - say - only 50% coverage, at 90% effectiveness. That's not looking so good. I'm still trying to understand why an otherwise young and healthy person would want to get take one, or more likely multiple, shots of a C19 vaccine, given the risk from C19 is so low. What's the benef…
For those wondering how their vaccines will be distributed among countries during the next year when supply is constrained... it seems complicated. Pfizer is a US company, but has at least one key ingredient from Austria, is made with technology from Germany, has manufacturing in US+Europe, etc. Pfizer's CEO answered this question this morning on CNBC. Pfizer has two separate manufacturing divisions- one in the US (M…
Do you have more information about the ingredient from Austria?
https://www.wsj.com/articles/if-one-leading-coronavirus-vacc...
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Trust. Russia and China lie through their teeth on everything and anything. It's irrelevant whether or not they are lying in this particular instance: they cannot be trusted.
America launched a fake vaccination campaign to catch osama-bin-laden; many villagers in surrounding areas are refusing to take vaccine because they have lost trust. Western governments are no doubt better for their own citizens than say Russia or China, but we outsiders have absolutely no reason to trust one government over the others. Russia's vaccine has only passed phase 2- now that's a good point, "Trust" absolu…
That doesn't necessarily mean it was justified, but I do think it's important to note the difference.
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No, it won't. they are projecting 50 million doses to be ready in 2020 and 1.1 billion next year. That means that mom and dad and grandma are likely to get it within the next few months and that by mid next year, you'll probably have access to it if you are a healthy thirty year old.
Those 1.1 billion doses are not for the US alone. The vaccine was actually developed by Biontech in Germany before Pfizer was involved. Pfizer is the partner to scale up the studies and production. But you can assume that those doses are not US only. And then I'd doubt that a healthy 30 year old will get it in summer of 2021.
Good: + ~90% of individuals achieve immunity. + no significant side-effects. Not so good: - two doses needed, 3 weeks apart, immunity after one month from first dose. Slow rollout. - -80C storage and transport needed. Challenging, but doable in developed countries, but still may slow down mass rollout. Not feasible in many developing countries. I still wonder about long-term immunity. Anyone can share any insight?
Also bad: What did they use to stabilize the mRNA? If they’re managing to do it with just temperature and maybe glycerol, that’s great. If it’s RNAlater, then that’s going to have safety issues. If it’s something else, how was the additive tested for long term safety? (Vaccines like this have been in the works for a long time. There has been time for safety studies.) Edit: RNAlater MSDS sheet: https://tools.thermofis…
Good: + ~90% of individuals achieve immunity. + no significant side-effects. Not so good: - two doses needed, 3 weeks apart, immunity after one month from first dose. Slow rollout. - -80C storage and transport needed. Challenging, but doable in developed countries, but still may slow down mass rollout. Not feasible in many developing countries. I still wonder about long-term immunity. Anyone can share any insight?
How does this compare to the chinese vaccine? It's already in use around the world[1], but I haven't heard of how many people gain immunity thanks to it in percentage, nor if that one also requires multiple jabs. 1. https://www.aljazeera.com/news/2020/11/3/uae-pm-and-dubai-ru...