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Covid vaccine: First ‘milestone’ vaccine offers 90% protection

bbc.co.uk

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Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#131

Post by ByteJockey »

grumple wrote: post #95
m12k wrote: post #69

"However, there are logistical challenges as the vaccine has to be kept in ultra-cold storage at below minus 80C." Does anyone know how many of the other vaccine candidates have this limitation? It seems to me that a vaccine with easier logistics might still end up having a bigger impact overall, despite not being the first - although that of course needs to be combined with the ease of production too (I don't know h…

I know that several of the vaccine candidates require similarly cold storage for their entire distribution cycle until they are being used. Disclaimer: I work for big pharma.

How long, exactly, are they good for once they warm up?

I assume you aren't injecting people with something at -80C. How big of a window is there for injections?

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#132

Post by Roonerelli »

3dbrows wrote: post #5

At the time of writing (2020-11-09 12:04 UTC) the article uses "90% of people" and "90% protection" interchangeably. I assume it means "90% of individuals achieve immunity", rather than "individuals achieve 90% immunity". EDIT: See child comment re: Pfizer press release. EDIT 2: See [1] for said press release, which has more detailed information than the BBC article. [1] https://investors.pfizer.com/investor-news/pre…

Excellent news it's so high. For comparison, MMR is 88% effective on Mumps

"One dose of MMR vaccine is 93% effective against measles, 78% effective against mumps, and 97% effective against rubella.

Two doses of MMR vaccine are 97% effective against measles and 88% effective against mumps."

https://www.cdc.gov/vaccines/vpd/mmr/public/index.html#:~:te....

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#133

Post by andy_ppp »

empthought wrote: post #45
andy_ppp wrote: post #28

Earlier quoted context omitted.

What extra does a virus have over and above some RNA? Is it just a spike protein for injection into a cell or does it depend?

The RNA is read by human cells and the spike protein antigen is created by human cells; it’s not particularly viral RNA.

Okay pretty terrifying! How long does this random RNA stay in your cells?

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#134

Post by kgwgk »

aphextron wrote: post #66
sixQuarks wrote: post #60

Earlier quoted context omitted.

You’re way too late to the party. Peloton became a $30 billion company during covid. Down over 10% in premarket trading

>You’re way too late to the party. Peloton became a $30 billion company during covid. Down over 10% in premarket trading He's mocking people who are making obvious short sighted covid-based stock plays.

Or maybe he didn't understand the reference to industrial sized extra cold freezers?

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#135

Post by coldpie »

TomGullen wrote: post #2

Great news and the markets are reacting very positively to the news as well which indicates to me this could be the beginning of the end!

Yeah, setting aside all the politics and silliness, the science going on around this pandemic is remarkable. Going from nearly zero (yes, there was a bunch of research from SARS-Cov-1, MERS, and similar to build off of but nothing like this) to a functioning, tested, and mass manufactured vaccine in a year is absolutely jaw dropping. Even if it takes two years to distribute widely, three years to stomp out a pandemic is blindingly fast and a major credit to modern medical science, and the processes we have built up around it.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#138

Post by cecja »

rq1 wrote: post #87

The virus is (heavily) mutating folks. Heavy mutations likely related to recombination with rhino-viruses. This vaccine will likely be outdated when generally available.

FUD spreading arm chair scientist all the ol pepes have to get on to another topic with trump out of the picture.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#139

Post by rq1 »

howlgarnish wrote: post #130
rq1 wrote: post #87

The virus is (heavily) mutating folks. Heavy mutations likely related to recombination with rhino-viruses. This vaccine will likely be outdated when generally available.

The mutations seen so far are minor and don't appear to impact our ability to vaccinate against them.

There are reported cases of people who built up immunity against the Chinese strain and got infected with the European strain while still having antibodies for the first one.

Danish are killing 17M minks because of a novel mutation that infected 12 people (reported).

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#140

Post by jessaustin »

refurb wrote: post #51
londons_explore wrote: post #30

Earlier quoted context omitted.

While it's a minor logistical challenge, it's simple enough to ship this in a liquid nitrogen dewar. Even very small cities will have liquid nitrogen facilities. Shipping from the nearest city to most of the population sounds very doable in 24 hours. Remember you only need to get most of the population to halt the spread. If there's some tiny village 3 days hike away in the rainforest, you can skip them.

Shipping hundreds of thousands of doses of vaccine at -80C is more than a “minor logistical challenge”. First, you’d never ship in a liquid nitrogen dewar. It would be a massive logistics bottleneck considering the weight of dewars and the volume you'd be shipping (Pfizer already has deals secured for hundreds of millions of doses). And plus, these are packaged vaccines - a glass vial with a label, in a paper box, wi…

When we buy cattle semen it's always shipped in liquid nitrogen tanks. UPS knows how to do this. It is more expensive than other sorts of shipping.
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