Live data from Hacker News

New study finds psilocybin greatly and quickly relieves depression

psychnewsdaily.com

11–20 of 201 posts

Re: New study finds psilocybin greatly and quickly relieves depression

#11
post #3

As someone with major depression, it helps temporarily but doesn’t last.

Works for mine. I need to take a heroic dose (5 gr) and then it lasts about 3 months before I need to again.

Isn't that what the parent post said? Works temporarily but doesn't last?

Re: New study finds psilocybin greatly and quickly relieves depression

#12
post #3

As someone with major depression, it helps temporarily but doesn’t last.

Have you tried ketamine? I suffered from major depression for years and it was the only thing that helped me. It was like flipping a switch.

Re: New study finds psilocybin greatly and quickly relieves depression

#13

Earlier quoted context omitted.

Just passed in Oregon: Oregon Measure 109. Legalize Psilocybin Permits licensed service providers to administer psilocybin-producing mushroom and fungi products to individuals 21 years of age or older.

Here's my issue with that: Who are the service providers of the treatment and what training have they taken to do so? There is some available through folks who did original research (eg: John Hopkins) and now do talk and demo circuits but otherwise it's all largely undefined. I'm paranoid of what this might lead to without strong community standards and ethics. A good first step, but lets hope it doesn't ruin it for…

It's undefined because it's just getting started. You can't make a substance legal and have all the necessary training and infrastructure available from day 1.

Re: New study finds psilocybin greatly and quickly relieves depression

#14

+ With (exceptionally) long term, positive effects when coupled with therapy before, during, and after strong psychedelic trips. Ultimately, the research results (and anecdotal evidence) for psilocybin are too great to ignore. The next question is - How does it get legalized (which we're seeing the stirrings of) and who gets access to it and how when it is?

Initiative 81[1] passed in DC. Still not legal but it looks like the will is there.

[1] https://decrimnaturedc.org/initiative-81/

Re: New study finds psilocybin greatly and quickly relieves depression

#15
post #3

As someone with major depression, it helps temporarily but doesn’t last.

Works for mine. I need to take a heroic dose (5 gr) and then it lasts about 3 months before I need to again.

Similar for me. No idea of the gram dosage but... a lot. Effect lasted about 6 months, then tapered off slowly.

Repeated again roughly yearly. After 4 difficult and unpleasant trips I'm fine. Never reached the sense of utter well-being I have for the few months after a trip but I'm fine.

I will say that drinking any alcohol basically negates the positive effects for me for a while. As in, I'll have a cocktail and then won't feel "right" again for a month or so.

Re: New study finds psilocybin greatly and quickly relieves depression

#17
post #5

I'm curious if we have insights into whether psychedelics' mental health effects work by changing something by a direct chemical interaction, or if they work by just encouraging the patient to rewire their own brain while tripping. If e.g. you administered psychedelics on someone in an induced coma, would you see the same benefit?

IIRC there were studies done to that effect with subjects in comas with various psychedelics, where there were no effects. Regard this with a large grain of salt though, I read that somewhere a long time ago and don't have a source rn.

Re: New study finds psilocybin greatly and quickly relieves depression

#18
post #3

As someone with major depression, it helps temporarily but doesn’t last.

Have you tried ketamine? I suffered from major depression for years and it was the only thing that helped me. It was like flipping a switch.

Did you find a doctor, or otherwise? I have severe chronic pain, and resulting depression that affects my pain perception, and am interested in trying this route.

Re: New study finds psilocybin greatly and quickly relieves depression

#19

>New study finds psilocybin greatly and quickly relieves depression Nope, it doesn't. The study wasn't placebo controlled. The placebo effect will have a large effect in a study like this, so we have no idea what effect the psilocybin had.

I wonder about posts with studies like these when just earlier there was one about how to read scientific papers.
Post reply on HN