Earlier quoted context omitted.
Does Chrome no longer have the option to disable cache while dev tools is open?
It sure does and it works, not sure how or what use case the parent has problems with. Would be quite interesting to find out.
Issue 645845 (Open, ~4 years old): DevTools: "disable cache" doesn't work for media resources: https://bugs.chromium.org/p/chromium/issues/detail?id=645845
Issue 470030 (WontFix): 'Disable cache' should prevent HSTS redirects: https://bugs.chromium.org/p/chromium/issues/detail?id=574345
Issue 775435 (Fixed after ~1 year): Disable cache does not disable cached redirects https://bugs.chromium.org/p/chromium/issues/detail?id=775435