Earlier quoted context omitted.
What does backwards compatibility mean in this context?
For example, will my opinion of Ayn Rand have to change?
What?
Intermittent fasting increases hippocampal neurogenesis in mice
81–90 of 123 posts
Re: Intermittent fasting increases hippocampal neurogenesis in mice
#82I feel like the term intermittent fasting is used by many folks to mean different things. It would be nice if there were more precise terminology here so we could communicate more clearly.
From the fine article: >We evaluated the impact of 3 months of IF (12, 16, and 24 hr of food deprivation on a daily basis)
>>12, 16, and 24 hr of food deprivation on a daily basis
given different metabolism speed and body energy stores depletion rate that would translate into days for humans.
Sidenote: it is not a good thing to torture animals.
Re: Intermittent fasting increases hippocampal neurogenesis in mice
#83Can someone add IN MICE to the title?
We are going to end up with the healthiest mice the world has ever seen.
Re: Intermittent fasting increases hippocampal neurogenesis in mice
#84Earlier quoted context omitted.
For example, will my opinion of Ayn Rand have to change?
What?
Will my values change in ways that they are unlikely to change without the changes to my brain? By analogy, drinking alcohol has temporarily affects on my judgement because it affects my brain chemistry and on the whole it makes my judgement worse (although sometimes it has removed unhelpful inhibitions).
To me the premise that the possibility of changing my brain through fasting is unquestionably a silver bullet free of tradeoffs is suspect. Or to put it another way, the fact that fasting had a particular effect does not imply that effect is a positive one.
Furthermore, hunger is a strong motivation toward behaviors that are ethically suspect in its absence. A full belly is a rung up Maslow’s hierarchy.
People who spend their days starving mice at scale have incentives to interpret that starvation in positive ways. It would be hard to rationalize starvation and vivisection otherwise and still consider one’s life choice reasonable and ethical. Hence, I am skeptical of acting in the ways an optimistic interpretation of the report suggests. YMMV.
Re: Intermittent fasting increases hippocampal neurogenesis in mice
#85Earlier quoted context omitted.
Did you notice any benefits of autophagy? I’ve always been curious if a long fast would clear up random stuff like knee pain (or even gum disease)
My 5 -7 day water fasts helped with some minor skin issues and I have no joint pain anymore, but that might be from losing some serious weight. For every 1 pound of body weight you lose, I have heard it removes 4 lbs of pressure on the knee and lower back. My 12 plus day water fast cleared up any remaining skin blemishes and a little Vitiligo between my fingers disappeared. I'm thinking after a year of monthly 5-7 da…
I am super interested to hear more about the vitiligo clearing up! Can you elaborate?
Re: Intermittent fasting increases hippocampal neurogenesis in mice
#86I fast pretty easily from 6pm to noon the next day. So I would be getting an awesome 18 hour fast daily however I have coffee with milk at 8am. Am I cancelling out those last 4 hours? I hate black coffee so I’m not sure what I could do.
Depends on why you are fasting. A little milk won’t kick you out of ketosis, particularly if it is higher fat. But for autophagy benefits, it might.
Re: Intermittent fasting increases hippocampal neurogenesis in mice
#87Earlier quoted context omitted.
Super interested in how the mice who experienced daily 24 hr food deprivation for 3 months did in the study.
actually there are studies especially from David Sinclair that shows that fasting and calorie restrictions help mice live longer and healthier. For those interested here is a great interview with David Sinclair, Harvard Researcher on aging: https://www.youtube.com/watch?v=8ZqAKNPxaxc
I'm very skeptical of any diet related advice based on studying mice. Mouse metabolism is very different from human metabolism.. Fasting a mouse for 24 hours will result in a fairly large loss of body mass. Fasting a person for 24 hours will result in a pound or two of weight loss.
I'm not against doing these kinds of studies on mice but the only conclusion you can really get is that we should do longer studies on animals that are closer to humans or on humans themselves.
Re: Intermittent fasting increases hippocampal neurogenesis in mice
#88Earlier quoted context omitted.
What?
Will my values change in ways that they are unlikely to change without the changes to my brain? By analogy, drinking alcohol has temporarily affects on my judgement because it affects my brain chemistry and on the whole it makes my judgement worse (although sometimes it has removed unhelpful inhibitions). To me the premise that the possibility of changing my brain through fasting is unquestionably a silver bullet fre…
This is a much more perceptive set of comments than I originally understood them to be. Thank you.
Re: Intermittent fasting increases hippocampal neurogenesis in mice
#89Details to pay attention to; - It is not stated if the diets are isocaloric or hypocaloric; probably because it wasn't measured. Timing restrictions and calorie restrictions are two different stressors on the body, and all else being equal stress is positively correlated with neurodegenerative effects. It might as well be only isocaloric intermittent fasting is indicative of BDNF increase and hippocampal neurogenesis…
"stress is positively correlated with neurodegenerative effects"
Can you provide some references to this?
Re: Intermittent fasting increases hippocampal neurogenesis in mice
#90Earlier quoted context omitted.
What?
Will my values change in ways that they are unlikely to change without the changes to my brain? By analogy, drinking alcohol has temporarily affects on my judgement because it affects my brain chemistry and on the whole it makes my judgement worse (although sometimes it has removed unhelpful inhibitions). To me the premise that the possibility of changing my brain through fasting is unquestionably a silver bullet fre…
I don't think that we need to apply a value to neurogenesis and I do not think the authors do either except that it seems to be correlated with other quote good behaviors like exercise.
Presumably neurogenesis is occurring all the time and is restricted to a small set of regions in the brain and the new neurons form in just those very strict set of regions. Those neurons are not moving to the neocortex, just a few millimeters within the dentate gyrus. That is to say even robust neurogenesis is not likely to change your mind, cognitive experience, personality or intelligence in any measurable way.