71–80 of 123 posts
Every time I see a research being published on HN, it ends up being a mouse model. Is there a place on the internet where I can see a list of publications describing the final (or close to final) stage of a research made on humans? Mouse model researches worsen my overall abstraction of where the humanity, in a scientific sense, is.
Earlier quoted context omitted.
Main goal for these kinds of fasts is weight loss, reducing insulin resistance and particularly extended fasts to achieve autophagy where your cells do internal house keeping to clean out broken cellular components and repair themselves.
Did you notice any benefits of autophagy? I’ve always been curious if a long fast would clear up random stuff like knee pain (or even gum disease)
My only regret is that I wasn't able to have someone doing a study or researching fasting monitor and harvest the wealth of information that was available.
- It is not stated if the diets are isocaloric or hypocaloric; probably because it wasn't measured. Timing restrictions and calorie restrictions are two different stressors on the body, and all else being equal stress is positively correlated with neurodegenerative effects. It might as well be only isocaloric intermittent fasting is indicative of BDNF increase and hippocampal neurogenesis.
- Fasting time is a very specific slice of the circadian rhythm; between 15:00–07:00, so this study is only skipping dinner and not breakfast. This is important because body has different stress responses early in the morning (we wake up with higher cortisol levels) and our insulin mechanism also reacts differently to food deprivation based on time of the day.
- Limits of animal models already mentioned, and I think it is particularly compounded around the concerns around timing and bioeconomics of growing brain regions. Mice and humans have similar encephalization quotients, but size of neural cells are constant between both, so is the cost to create or upkeep them. Same concern goes for the number of days of energy each animals bodies can store. So the underlying calculus to make new brain cells or not might be vastly different. For example maybe humans need to undergo a much longer (e.g. multiday) fast before this effect kicks in.
Interesting and lines up with other brain development factors found in human fasting ( https://cdnsciencepub.com/doi/abs/10.1139/apnm-2014-0290 ). I often read these threads about fasting/intermittent fasting on HN and see a lot of nitpicking about flaws in the study. Given that almost all studies tend to fall between "no effect" or "clear positive effect" of fasting on health, do we have enough evidence to say "fast…
My opinion: I think it's a qualified "yes." If you can successfully pull it off, there's substantial evidence it is generally beneficial. But I have a genetic disorder that impairs fat processing (so I had no real fat stores to draw on while fasting) and I began fasting or semi fasting while homeless at times when I was too broke to afford food. Initially, it was extremely hard on me. I routinely threw up on fasting…
There is a reboot procedure for getting the system going again. After a 3-day fast, mine was something like this:
Turmeric and ginger Tea
+ 30 minutes
bone broth
+ 30 minutes
sauerkraut
+ 30 minutes
almonds / pumpkin seeds / sunflower seeds
+ 45 minutes
avocado
+ 30 minutes
soup (bone broth / chicken broth, kale, tofu, chard, napa)
+ 45 minutes
yogurt
nuts / seeds ... beef bowl for dinner (rice, onions, simple vegetable side)
The logic behind this is that the turmeric and ginger causes a (very mild) inflammatory response in the stomach. It gets the body "ready" for food again.
The bone broth supplies a very mild, easily digestible form of protein that resupplies immediate deficits. Sauerkraut supplies good digestive bacteria to rebuild your population of digestive helpers. This helps prevent diarrhea, though not entirely.
Almonds, pumpkin seeds, sunflower seeds (preferably unsalted) begin supplying dense packets of minerals. Don't have too much, but a few handfuls will be a good start.
Avacado! Calories (from good fat) and minerals, and more fiber.
The soup is the first serious nourishment. The tofu, chard, kale, and napa provide a range of good stuff. Protein from the tofu, and more minerals and fiber from the leafy greens. Lightly salted broth, (a mix of bone broth and chicken broth for flavor) is also good.
Yogurt (active culture) provides calcium and fat, and another excellent boost to helper bacteria.
More snacking on the nuts and seeds as you like...
A light dinner of thin slices of ribeye with onions and soy sauce over rice, and a nice cruciferous vegetable blanched, dressed with a touch sesame oil and salt.
Rebooted!
The waits in between are important, as is continued hydration along the way.
All that said, many of the benefits you supposedly get from 3-day / 5-day fasts, can be had from reduced calorie diets.
Seems to get some portion of the benefits.
Earlier quoted context omitted.
From the fine article: >We evaluated the impact of 3 months of IF (12, 16, and 24 hr of food deprivation on a daily basis)
If 12H is considered IF, then I have been intermittently fasting for the last 4-5 years.
12 is better than, say, 8 or 6 (e.g., snacking at night).
Curious how your experience compares to your pre-IF state 5+yrs ago?
I fast pretty easily from 6pm to noon the next day. So I would be getting an awesome 18 hour fast daily however I have coffee with milk at 8am. Am I cancelling out those last 4 hours? I hate black coffee so I’m not sure what I could do.
The coffee is fine though. Maybe try it iced?
Interesting and lines up with other brain development factors found in human fasting ( https://cdnsciencepub.com/doi/abs/10.1139/apnm-2014-0290 ). I often read these threads about fasting/intermittent fasting on HN and see a lot of nitpicking about flaws in the study. Given that almost all studies tend to fall between "no effect" or "clear positive effect" of fasting on health, do we have enough evidence to say "fast…
My opinion: I think it's a qualified "yes." If you can successfully pull it off, there's substantial evidence it is generally beneficial. But I have a genetic disorder that impairs fat processing (so I had no real fat stores to draw on while fasting) and I began fasting or semi fasting while homeless at times when I was too broke to afford food. Initially, it was extremely hard on me. I routinely threw up on fasting…
Try resuming with an at least slightly green banana. It's a really effective tool vs. diarrhea in general, but I've found it to also be a great restart after fasting.