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Intermittent fasting increases hippocampal neurogenesis in mice

pubmed.ncbi.nlm.nih.gov

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Re: Intermittent fasting increases hippocampal neurogenesis in mice

#51

Post by kilbuz »

obblekk wrote: post #48

Interesting and lines up with other brain development factors found in human fasting ( https://cdnsciencepub.com/doi/abs/10.1139/apnm-2014-0290 ). I often read these threads about fasting/intermittent fasting on HN and see a lot of nitpicking about flaws in the study. Given that almost all studies tend to fall between "no effect" or "clear positive effect" of fasting on health, do we have enough evidence to say "fast…

Definitely not. Nutrition and dietary studies are famously hard to draw any solid conclusions from due to the logistical challenges of performing quality studies (randomization, blinding, "placebo" effects, adherence, follow-up, ...). Additionally, do we assume these effects are consistent for everyone, or certain age groups, genetic markers, ethnicities, etc. Even within individuals, would effects be beneficial for the whole lifetime?

It seems balance and "do what works for you" would be the recommendation.

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#52

Post by baxtr »

mrfusion wrote: post #45
baxtr wrote: post #41

Earlier quoted context omitted.

That’s what I did for a long time. But somehow it didn’t feel right. I then switched to 4pm to 8am. Works way better for me now

So early dinner? And then a big breakfast? It’s hard with a family though if they’re on different schedules.

No real dinner, just a snack in the afternoon. But yes, breakfast and lunch are a bit heavier. When I think about it, maybe it works better now because of lockdown and WFH...dunno

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#53

Post by treeman79 »

waihtis wrote: post #27
ei8htyfi5e wrote: post #15

Earlier quoted context omitted.

They eat once a day... so I’m sure they’re fine...

Fun fact: Mice can only survive 48 hours without food, so not eating for 24 hours is quite long for them.

Had recently gotten two mice.

We were upstairs when we realized it was the first ice cold night of the year.

So we went down and mice are cuddled in the cold , and apparently out of food.

Someone decided fruit loops mixed in with mouse food was a good idea. One mouse went and ate. Other one was clearly in roughed shap.

First mouse took a fruit loop, walked it over, and kept putting it against the others mouth. After couple minutes she started eating.

The sheer empathy of one mouse helping another still gets to me.

They both were fine after eating and being moved to a warm spot.

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#54

Post by calf »

travisjungroth wrote: post #49
mrfusion wrote: post #32

I fast pretty easily from 6pm to noon the next day. So I would be getting an awesome 18 hour fast daily however I have coffee with milk at 8am. Am I cancelling out those last 4 hours? I hate black coffee so I’m not sure what I could do.

Maybe. I think in the study the rats were fully fasted, so you’re into unknown territory as far as the study goes. But I also assume you’re not a rat, so that’s not exactly the biggest difference. There are lots of definitions of fasting and it’s not perfectly understood which consequences line up with which behaviors. It’s pretty clear things are different once you break down the different ideas of “fast” and build…

Also, I think the rats were not humans.

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#55

Post by pachico »

faichai wrote: post #31
pachico wrote: post #18

Earlier quoted context omitted.

I hope you don't mind me asking but why did you fast for 12 days?

Main goal for these kinds of fasts is weight loss, reducing insulin resistance and particularly extended fasts to achieve autophagy where your cells do internal house keeping to clean out broken cellular components and repair themselves.

And doesn't it come at a price health-wise?

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#56

Post by eznzt »

waihtis wrote: post #27
ei8htyfi5e wrote: post #15

Earlier quoted context omitted.

They eat once a day... so I’m sure they’re fine...

Fun fact: Mice can only survive 48 hours without food, so not eating for 24 hours is quite long for them.

What determines how long you can survive without food? The speed of your metabolism?

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#57

Post by clopez »

mrfusion wrote: post #32

I fast pretty easily from 6pm to noon the next day. So I would be getting an awesome 18 hour fast daily however I have coffee with milk at 8am. Am I cancelling out those last 4 hours? I hate black coffee so I’m not sure what I could do.

Take pills of pure caffeine. Easy and cheap to find on any drugstore or Amazon or any specialized online shop. I stopped taking roasted coffee because i got concerned about acrylamide and now doing much better on just pills of caffeine.

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#58

Post by csomar »

diydsp wrote: post #6
netfl0 wrote: post #5

I feel like the term intermittent fasting is used by many folks to mean different things. It would be nice if there were more precise terminology here so we could communicate more clearly.

From the fine article: >We evaluated the impact of 3 months of IF (12, 16, and 24 hr of food deprivation on a daily basis)

If 12H is considered IF, then I have been intermittently fasting for the last 4-5 years.

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#59

Post by hannofcart »

brudgers wrote: post #44
ahmedfromtunis wrote: post #23

For anyone wondering: > Adult hippocampal neurogenesis is a process that describes the generation of new functional DGCs from adult neural stem cells through the amplification of intermediate progenitors and neuroblasts, as well as the integration of these new neurons into the existing neural circuits. Source: https://www.nature.com/articles/s41380-018-0036-2#:~:text=Ad... .

Is this a breaking change or backwards compatible?

What does backwards compatibility mean in this context?

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#60

Post by clopez »

clopez wrote: post #57
mrfusion wrote: post #32

I fast pretty easily from 6pm to noon the next day. So I would be getting an awesome 18 hour fast daily however I have coffee with milk at 8am. Am I cancelling out those last 4 hours? I hate black coffee so I’m not sure what I could do.

Take pills of pure caffeine. Easy and cheap to find on any drugstore or Amazon or any specialized online shop. I stopped taking roasted coffee because i got concerned about acrylamide and now doing much better on just pills of caffeine.

Also with just caffeine you dont have any longer the usual problems of intestinal discomfort that coffee causes.
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